{"id":"https://openalex.org/W1490576088","doi":"https://doi.org/10.1016/s0021-9258(19)49865-7","title":"EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.","display_name":"EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W1490576088","doi":"https://doi.org/10.1016/s0021-9258(19)49865-7","mag":"1490576088","pmid":"https://pubmed.ncbi.nlm.nih.gov/1375934"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)49865-7","doi":"https://doi.org/10.1016/s0021-9258(19)49865-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)49865-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)49865-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038425390","display_name":"Jack R. Lancaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J R Lancaster","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109999237","display_name":"Jan Michael Langrehr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.M. Langrehr","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033569480","display_name":"Hector A. Bergonia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.A. Bergonia","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113498534","display_name":"Noriko Murase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Murase","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108903982","display_name":"Richard L. Simmons","orcid":"https://orcid.org/0000-0001-6735-9913","observed_orcids":["https://orcid.org/0000-0001-6735-9913"]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.L. Simmons","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009273319","display_name":"Rosemary A. Hoffman","orcid":"https://orcid.org/0000-0001-9159-6994","observed_orcids":["https://orcid.org/0000-0001-9159-6994"]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.A. Hoffman","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Utah State University, Logan 84322-0300","institution_ids":["https://openalex.org/I121980950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121980950"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":9.1263,"has_fulltext":false,"cited_by_count":193,"citation_normalized_percentile":{"value":0.98152227,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"267","issue":"16","first_page":"10994","last_page":"10998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.3391000032424927,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12381","display_name":"Electron Spin Resonance Studies","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/iron-nitrosyl-complexes","display_name":"iron nitrosyl complexes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/heme-proteins","display_name":"heme proteins","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cardiac-allograft-rejection","display_name":"cardiac allograft rejection","score":0.8600000143051147},{"id":"https://openalex.org/keywords/alloimmunity","display_name":"alloimmunity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.7599999904632568},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.902999997138977},{"id":"https://openalex.org/keywords/alloantigen","display_name":"alloantigen","score":0.47600001096725464},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.656000018119812},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7287502288818359},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5825235247612},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5430663228034973},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.529651403427124},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4899579584598541},{"id":"https://openalex.org/C187961010","wikidata":"https://www.wikidata.org/wiki/Q260463","display_name":"Electron paramagnetic resonance","level":2,"score":0.4749232232570648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4473138749599457},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41124895215034485},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3901134133338928},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36401310563087463},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35914790630340576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2908073663711548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2872309982776642},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007519","descriptor_name":"Isoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007519","descriptor_name":"Isoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007519","descriptor_name":"Isoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019159","descriptor_name":"Nonheme Iron Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019159","descriptor_name":"Nonheme Iron Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019159","descriptor_name":"Nonheme Iron Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)49865-7","doi":"https://doi.org/10.1016/s0021-9258(19)49865-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)49865-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1375934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1375934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)49865-7","doi":"https://doi.org/10.1016/s0021-9258(19)49865-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)49865-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2027016159","display_name":null,"funder_award_id":"AI-16869","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1023736352","https://openalex.org/W1505955094","https://openalex.org/W1517806507","https://openalex.org/W1525976258","https://openalex.org/W1527105416","https://openalex.org/W1539977736","https://openalex.org/W1553215445","https://openalex.org/W1576090273","https://openalex.org/W1590997390","https://openalex.org/W1762742043","https://openalex.org/W1837781225","https://openalex.org/W1929009802","https://openalex.org/W1965077361","https://openalex.org/W1994303699","https://openalex.org/W1994389040","https://openalex.org/W1997728669","https://openalex.org/W1999539102","https://openalex.org/W2000677212","https://openalex.org/W2001766586","https://openalex.org/W2003281598","https://openalex.org/W2003794997","https://openalex.org/W2006179869","https://openalex.org/W2009013636","https://openalex.org/W2011677100","https://openalex.org/W2016470389","https://openalex.org/W2032100719","https://openalex.org/W2035987531","https://openalex.org/W2040150769","https://openalex.org/W2050218006","https://openalex.org/W2051896582","https://openalex.org/W2059379142","https://openalex.org/W2069915206","https://openalex.org/W2081480546","https://openalex.org/W2081620188","https://openalex.org/W2085014479","https://openalex.org/W2142575579","https://openalex.org/W2329610989","https://openalex.org/W2401494340","https://openalex.org/W2407737746","https://openalex.org/W2410398939"],"related_works":["https://openalex.org/W55177868","https://openalex.org/W1978520445","https://openalex.org/W2071610938","https://openalex.org/W2434501210","https://openalex.org/W2153434041","https://openalex.org/W1970382992","https://openalex.org/W2003281598","https://openalex.org/W2048672107","https://openalex.org/W4239641317","https://openalex.org/W98718818"],"abstract_inverted_index":{"The":[0],"paramagnetic":[1,65],"molecule":[2],"nitric":[3],"oxide":[4],"(NO),":[5],"produced":[6],"from":[7],"L-arginine":[8],"by":[9,60,194],"a":[10,22,48],"specific":[11],"enzyme":[12,55],"(NO":[13],"synthase),":[14],"has":[15],"been":[16],"shown":[17,70,108],"to":[18,36,62,100,102,135],"be":[19,91],"involved":[20],"in":[21,38,47,138,145,149,169,183,226],"surprising":[23],"variety":[24],"of":[25,32,51,53,73,86,94,98,117,153,158,176,196,206,218],"mammalian":[26],"cellular":[27],"responses,":[28],"including":[29],"the":[30,71,92,95,110,146,150,156,170,174,197,204,227],"regulation":[31],"T":[33],"cell":[34],"immunity":[35],"alloantigens":[37],"vitro.":[39],"In":[40],"cytotoxic":[41,124],"activated":[42],"macrophages,":[43],"NO":[44,99,111],"production":[45],"results":[46,201],"characteristic":[49],"pattern":[50],"alteration":[52,85],"iron-containing":[54,87,219],"function":[56,89,221],"that":[57,84,109,130,215],"is":[58],"mimicked":[59],"exposure":[61],"NO.":[63],"Electron":[64],"resonance":[66],"(EPR)":[67],"studies":[68],"have":[69,106],"formation":[72,205],"iron-nitrosyl":[74,131,207],"species":[75],"during":[76,81,114,141,155,209],"macrophage":[77],"activation":[78,116],"and":[79,123,140,148,172,189,191,213],"also":[80],"sepsis,":[82],"indicating":[83],"protein":[88,220],"may":[90],"result":[93],"well-documented":[96],"tendency":[97],"bind":[101],"metal":[103],"ions.":[104],"We":[105],"recently":[107],"synthesis":[112],"induced":[113],"alloantigenic":[115],"rat":[118],"splenocytes":[119],"inhibits":[120],"lymphocyte":[121],"proliferation":[122],"T-lymphocyte":[125],"generation.":[126],"This":[127],"report":[128],"demonstrates":[129],"EPR":[132],"signals":[133,166],"similar":[134],"those":[136],"observed":[137],"macrophages":[139],"sepsis":[142],"are":[143,167,180,192],"present":[144],"blood":[147,171],"grafted":[151],"tissue":[152],"rats":[154],"rejection":[157,212,228],"allogeneic":[159],"(but":[160],"not":[161,181],"syngeneic)":[162],"heart":[163],"grafts.":[164],"These":[165,200],"found":[168,182],"at":[173],"site":[175],"allograft":[177,211],"rejection,":[178],"but":[179],"other":[184],"tissues":[185],"(such":[186],"as":[187],"spleen":[188],"lung),":[190],"obliterated":[193],"administration":[195],"immunosuppressant":[198],"FK506.":[199],"directly":[202],"demonstrate":[203],"complexes":[208],"vascularized":[210],"suggest":[214],"consequent":[216],"destruction":[217],"plays":[222],"an":[223],"important":[224],"role":[225],"response.":[229]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}