{"id":"https://openalex.org/W1490467085","doi":"https://doi.org/10.21236/ada405296","title":"Murine Models of Breast Cancer: Assessment of the Role of c-Src in Mammary Tumorigenesis","display_name":"Murine Models of Breast Cancer: Assessment of the Role of c-Src in Mammary Tumorigenesis","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W1490467085","doi":"https://doi.org/10.21236/ada405296","mag":"1490467085"},"language":"en","primary_location":{"id":"doi:10.21236/ada405296","doi":"https://doi.org/10.21236/ada405296","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada405296","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003338465","display_name":"Konstantina Alexandropoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantina Alexandropoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111890664","display_name":"Luzhou Xing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luzhou Xing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112739664","display_name":"R. Huber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Huber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/rap1","display_name":"Rap1","score":0.7860000133514404},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7519999742507935},{"id":"https://openalex.org/keywords/ras-gtpase","display_name":"Ras GTPase","score":0.7710000276565552},{"id":"https://openalex.org/keywords/src-phosphorylation","display_name":"Src phosphorylation","score":0.46799999475479126},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7491521239280701},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6990871429443359},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4435684084892273},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41551294922828674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4086079001426697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4067358672618866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37539470195770264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3049262762069702}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21236/ada405296","doi":"https://doi.org/10.21236/ada405296","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada405296","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA388873","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA388873","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"pmh:ADA405296","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA405296","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"pmh:ADA438240","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA438240","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1494821536","https://openalex.org/W1506096984","https://openalex.org/W1584978389","https://openalex.org/W1623683757","https://openalex.org/W1657138111","https://openalex.org/W1697523131","https://openalex.org/W1900495018","https://openalex.org/W1909995282","https://openalex.org/W1964884314","https://openalex.org/W1974517994","https://openalex.org/W1976214697","https://openalex.org/W1976999762","https://openalex.org/W1978798502","https://openalex.org/W1980000777","https://openalex.org/W1985651693","https://openalex.org/W1987184179","https://openalex.org/W1991683855","https://openalex.org/W1994305152","https://openalex.org/W1999673185","https://openalex.org/W2003849027","https://openalex.org/W2004339917","https://openalex.org/W2008725579","https://openalex.org/W2011984577","https://openalex.org/W2012806962","https://openalex.org/W2016955301","https://openalex.org/W2026778256","https://openalex.org/W2029149519","https://openalex.org/W2031442174","https://openalex.org/W2032770293","https://openalex.org/W2033429522","https://openalex.org/W2040319583","https://openalex.org/W2055181868","https://openalex.org/W2056527670","https://openalex.org/W2060248473","https://openalex.org/W2061831711","https://openalex.org/W2063259786","https://openalex.org/W2065111537","https://openalex.org/W2065289702","https://openalex.org/W2068172713","https://openalex.org/W2076897294","https://openalex.org/W2078011486","https://openalex.org/W2099481097","https://openalex.org/W2116045343","https://openalex.org/W2136477311","https://openalex.org/W2142203996","https://openalex.org/W2144634347","https://openalex.org/W2155723800","https://openalex.org/W2156875265","https://openalex.org/W2157342751","https://openalex.org/W2158608327","https://openalex.org/W2159018836","https://openalex.org/W2159972238","https://openalex.org/W2170503323","https://openalex.org/W2170910759","https://openalex.org/W2289265939","https://openalex.org/W2394683365","https://openalex.org/W2394752643","https://openalex.org/W2432316972"],"related_works":["https://openalex.org/W7049025120","https://openalex.org/W2230773530","https://openalex.org/W1278399141","https://openalex.org/W1499882773","https://openalex.org/W7098945183","https://openalex.org/W1550582634","https://openalex.org/W2053214539","https://openalex.org/W1992873952","https://openalex.org/W2748494915","https://openalex.org/W1988336108"],"abstract_inverted_index":{"Strong":[0],"evidence":[1],"exists":[2],"that":[3,38,58,80,97,104,121,143,249],"the":[4,13,27,36,107,110,118,157,177,181,196,209,236,245],"c-Src":[5,30,63],"non-receptor":[6],"tyrosine":[7],"kinase":[8,120],"plays":[9],"a":[10,77,84,101],"role":[11,28,210],"in":[12,31,43,122,148,184,195,214,220],"pathology":[14],"of":[15,21,29,71,86,109,199,211,238,247],"human":[16],"breast":[17,48],"tumors.":[18],"The":[19],"purpose":[20],"this":[22],"study":[23,65],"is":[24,81,154,164],"to":[25,40,61,89,106,244],"examine":[26],"mammary":[32,218],"tumorigenesis":[33,219,240],"and":[34,64,91,137,187,191,217,223,228,241],"elucidate":[35],"mechanisms":[37,146,198,237],"lead":[39,243],"tumor":[41],"formation":[42],"an":[44],"animal":[45],"model":[46],"for":[47,176,255],"cancer.":[49],"In":[50,128,202],"our":[51,203],"previous":[52],"experiments":[53,205,231],"we":[54,59,75,131,141,206],"used":[55,252],"Src":[56,90,136,139,152,162,189,227],"substrates":[57],"cloned":[60],"activate":[62],"its":[66],"signaling":[67,78,102,145,153,163,190,197],"mechanisms.":[68],"Using":[69],"one":[70],"these":[72,200],"substrates,":[73],"Sin,":[74],"characterized":[76],"cascade":[79,159],"activated":[82,134],"as":[83,168,170,253],"result":[85],"Sin":[87,93,99,133],"binding":[88],"Src-mediated":[92,239],"phosphorylation.":[94],"We":[95],"found":[96,142],"Src-phosphorylated":[98],"recruits":[100],"complex":[103],"leads":[105],"activation":[108,213],"small":[111],"GTP-binding":[112],"protein":[113,140],"Rap1.":[114],"Rap1":[115,158,182,212],"then":[116],"activates":[117],"ERK":[119],"turn":[123],"mediates":[124],"Src-dependent":[125],"transcriptional":[126],"activation.":[127],"addition,":[129],"when":[130],"compared":[132],"wild-type":[135],"oncogenic":[138,161,188],"their":[144],"differed":[147],"that,":[149],"wild":[150,185],"type":[151,186],"mediated":[155,165],"by":[156,166],"whereas":[160],"Rap1,":[167],"well":[169],"another":[171],"G-protein,":[172],"Ras.":[173],"Our":[174],"results":[175],"first":[178],"time":[179],"implicate":[180],"pathway":[183],"reveal":[192],"mechanistic":[193],"differences":[194],"proteins.":[201],"future":[204],"will":[207,232,250],"address":[208],"cellular":[215],"transformation":[216],"cell":[221],"lines":[222],"transgenic":[224],"mice":[225],"co-expressing":[226],"Sin.":[229],"These":[230],"provide":[233],"insight":[234],"into":[235],"may":[242],"identification":[246],"proteins":[248],"be":[251],"targets":[254],"drug":[256],"development.":[257]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
