{"id":"https://openalex.org/W149039554","doi":null,"title":"Detection of abnormal pretransplant clones in progenitor cells of patients who developed myelodysplasia after autologous transplantation.","display_name":"Detection of abnormal pretransplant clones in progenitor cells of patients who developed myelodysplasia after autologous transplantation.","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W149039554","mag":"149039554","pmid":"https://pubmed.ncbi.nlm.nih.gov/10477708"},"language":"en","primary_location":{"id":"pmid:10477708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10477708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061902084","display_name":"Elisabetta Abruzzese","orcid":"https://orcid.org/0000-0001-5228-6491","observed_orcids":["https://orcid.org/0000-0001-5228-6491"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Abruzzese","raw_affiliation_strings":["Section on Hematology and Oncology, the Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1082, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Hematology and Oncology, the Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1082, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113528914","display_name":"James E. Radford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Radford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027151969","display_name":"Jeffrey S. Miller","orcid":"https://orcid.org/0000-0002-0339-4944","observed_orcids":["https://orcid.org/0000-0002-0339-4944"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Miller","raw_affiliation_strings":["Medicine - Hematology, Oncology, Transplant"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine - Hematology, Oncology, Transplant","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014505996","display_name":"James J. Vredenburgh","orcid":"https://orcid.org/0000-0002-2935-6057","observed_orcids":["https://orcid.org/0000-0002-2935-6057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Vredenburgh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113730911","display_name":"P. Nagesh Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P N Rao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111530671","display_name":"Mark J. Pettenati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Pettenati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112156220","display_name":"Julia M. Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012446508","display_name":"James J. Perry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Perry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080855457","display_name":"Sergio Amadori","orcid":"https://orcid.org/0000-0002-2356-8681","observed_orcids":["https://orcid.org/0000-0002-2356-8681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Amadori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113876581","display_name":"David Duane Hurd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D D Hurd","raw_affiliation_strings":["Wake Forest University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4269,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.97272349,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"94","issue":"5","first_page":"1814","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.3037000000476837,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-myelodysplastic-syndrome","display_name":"secondary myelodysplastic syndrome","score":0.9539999961853027},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/bone-marrow-derived-progenitor-cells","display_name":"bone marrow progenitor cells","score":0.6990000009536743},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8109999895095825},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.8019999861717224},{"id":"https://openalex.org/keywords/conventional-dose-chemotherapy","display_name":"conventional-dose chemotherapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6829025745391846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6571502685546875},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.6107563972473145},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5884660482406616},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5638606548309326},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.5480950474739075},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5250922441482544},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.49615487456321716},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48448821902275085},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4558578133583069},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.45577573776245117},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4469067454338074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32723021507263184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2640722990036011},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.07663276791572571},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019650","descriptor_name":"Hematopoietic Stem Cell Mobilization","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10477708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10477708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/50994","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/50994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W118466321","https://openalex.org/W156864325","https://openalex.org/W187238933","https://openalex.org/W197388266","https://openalex.org/W254205321","https://openalex.org/W1555752669","https://openalex.org/W1754349841","https://openalex.org/W1785638885","https://openalex.org/W1796305773","https://openalex.org/W1829759922","https://openalex.org/W1937538988","https://openalex.org/W1967194909","https://openalex.org/W1982513951","https://openalex.org/W1983392832","https://openalex.org/W1986873979","https://openalex.org/W2005849078","https://openalex.org/W2042310766","https://openalex.org/W2050179681","https://openalex.org/W2056529114","https://openalex.org/W2094663887","https://openalex.org/W2124307602","https://openalex.org/W2176579253","https://openalex.org/W2229863299","https://openalex.org/W2250049252","https://openalex.org/W2339359539","https://openalex.org/W2395585278","https://openalex.org/W2396610512","https://openalex.org/W2410215670","https://openalex.org/W2424609239","https://openalex.org/W2425220139","https://openalex.org/W2460075545","https://openalex.org/W2992983818"],"related_works":["https://openalex.org/W2061628268","https://openalex.org/W2316796638","https://openalex.org/W2171500805","https://openalex.org/W1974798066","https://openalex.org/W2410573249","https://openalex.org/W2171274285","https://openalex.org/W2037341400","https://openalex.org/W1986873979","https://openalex.org/W3092662859","https://openalex.org/W1964715915"],"abstract_inverted_index":{"Secondary":[0],"myelodysplastic":[1],"syndromes":[2],"(MDS)":[3],"have":[4],"been":[5,111],"reported":[6],"after":[7,56],"autologous":[8],"transplantation.":[9],"It":[10],"is":[11],"not":[12],"known":[13],"whether":[14],"the":[15,19,25,31,61,77,82,98,126,132,142,148,157,173],"MDS":[16,135],"results":[17,161],"from":[18,24,49,162],"pretransplant":[20,43,88,113],"conventional-dose":[21,164],"chemotherapy":[22,27,165],"or":[23,45,102,172],"high-dose":[26],"(HDC)":[28],"used":[29,69],"for":[30],"transplant":[32],"procedure.":[33],"We":[34],"performed":[35,112],"a":[36,118],"multicenter,":[37],"retrospective":[38],"analysis":[39,109],"of":[40,84,100,123,134,154],"morphologically":[41],"normal":[42,119],"marrow":[44],"stem":[46,93,158],"cell":[47,94,159],"specimens":[48],"12":[50,124],"patients":[51],"who":[52],"subsequently":[53],"developed":[54],"myelodysplasia":[55],"HDC.":[57],"To":[58],"determine":[59],"if":[60],"abnormal":[62],"clone":[63],"was":[64,137],"present":[65],"before":[66],"HDC,":[67],"we":[68],"fluorescence":[70],"in":[71,114,141,151],"situ":[72],"hybridization":[73],"(FISH)":[74],"to":[75,170],"detect":[76],"cytogenetic":[78,108,128],"markers":[79],"observed":[80,130],"at":[81,97,131],"onset":[83],"posttransplant":[85,155],"MDS.":[86],"Cryopreserved,":[87],"bone":[89],"marrow,":[90],"peripheral":[91],"blood":[92],"specimens,":[95],"obtained":[96],"time":[99,133],"harvest,":[101],"archival":[103],"smears":[104],"were":[105],"used.":[106],"Standard":[107],"had":[110],"four":[115],"patients,":[116],"showing":[117],"karyotype.":[120],"In":[121],"9":[122],"cases,":[125],"same":[127],"abnormality":[129],"diagnosis":[136],"detected":[138],"by":[139],"FISH":[140],"pre-HDC":[143],"specimens.":[144],"Our":[145],"findings":[146],"support":[147],"hypothesis":[149],"that,":[150],"many":[152],"cases":[153],"MDS,":[156],"damage":[160],"prior":[163],"and":[166],"may":[167],"be":[168],"unrelated":[169],"HDC":[171],"transplantation":[174],"process":[175],"itself.":[176]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
