{"id":"https://openalex.org/W1490179347","doi":"https://doi.org/10.4049/jimmunol.0713347","title":"IL-4 Is Proangiogenic in the Lung under Hypoxic Conditions","display_name":"IL-4 Is Proangiogenic in the Lung under Hypoxic Conditions","publication_year":2009,"publication_date":"2009-04-21","ids":{"openalex":"https://openalex.org/W1490179347","doi":"https://doi.org/10.4049/jimmunol.0713347","mag":"1490179347","pmid":"https://pubmed.ncbi.nlm.nih.gov/19380795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10204605"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.0713347","doi":"https://doi.org/10.4049/jimmunol.0713347","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.0713347","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/182/9/5469/1280590/zim00909005469.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/182/9/5469/1280590/zim00909005469.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008249109","display_name":"Kazuyo Yamaji-Kegan","orcid":"https://orcid.org/0000-0002-8500-972X","observed_orcids":["https://orcid.org/0000-0002-8500-972X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuyo Yamaji-Kegan","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067478990","display_name":"Qingning Su","orcid":"https://orcid.org/0000-0002-7043-9807","observed_orcids":["https://orcid.org/0000-0002-7043-9807"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingning Su","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072907627","display_name":"Daniel J. Angelini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J Angelini","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000845625","display_name":"Roger A. Johns","orcid":"https://orcid.org/0000-0001-9232-2434","observed_orcids":["https://orcid.org/0000-0001-9232-2434"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roger A Johns","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000845625"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":5.0521,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.95169699,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"182","issue":"9","first_page":"5469","last_page":"5476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pulmonary-angiogenesis","display_name":"pulmonary angiogenesis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/il-4-receptor-alpha","display_name":"IL-4 receptor alpha","score":0.8309999704360962},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/vegf-signaling-pathway","display_name":"VEGF pathway","score":0.7400000095367432},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.9440000057220459},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5370000004768372},{"id":"https://openalex.org/keywords/chronic-lung-disease","display_name":"chronic lung disease","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7780119180679321},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7564710378646851},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7004141807556152},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5428232550621033},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.47206929326057434},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43895524740219116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4243777394294739},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36277496814727783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3564009666442871},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3486960530281067},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34391993284225464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3296947479248047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3026679754257202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22378847002983093},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1768435537815094},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.13913023471832275},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053662","descriptor_name":"Interleukin-4 Receptor alpha Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.0713347","doi":"https://doi.org/10.4049/jimmunol.0713347","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.0713347","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/182/9/5469/1280590/zim00909005469.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:19380795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19380795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10204605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10204605","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10204605/pdf/nihms-1901076.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.0713347","doi":"https://doi.org/10.4049/jimmunol.0713347","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.0713347","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/182/9/5469/1280590/zim00909005469.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3421808071","display_name":"Targeting resitin and RELM-beta to treat pulmonary hypertension","funder_award_id":"UH2HL123827","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5686435993","display_name":"Regulation of NO Signaling in Pulmonary Vaculature","funder_award_id":"R01HL039706","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G831296288","display_name":"Targeting resitin and RELM-beta to treat pulmonary hypertension","funder_award_id":"P50HL107182","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8913527338","display_name":"Molecular Determinants of Pulmonary Arterial Hypertension","funder_award_id":"P50HL084946","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1490179347.pdf","grobid_xml":"https://content.openalex.org/works/W1490179347.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W204710094","https://openalex.org/W1481636931","https://openalex.org/W1496090723","https://openalex.org/W1599229342","https://openalex.org/W1882823390","https://openalex.org/W1965244343","https://openalex.org/W1968044382","https://openalex.org/W1968618681","https://openalex.org/W1971888466","https://openalex.org/W1976686594","https://openalex.org/W1981901332","https://openalex.org/W1988381312","https://openalex.org/W1993712652","https://openalex.org/W1997544393","https://openalex.org/W1997794457","https://openalex.org/W2005134410","https://openalex.org/W2014963245","https://openalex.org/W2015344488","https://openalex.org/W2020576064","https://openalex.org/W2021647387","https://openalex.org/W2023370394","https://openalex.org/W2023820705","https://openalex.org/W2032106677","https://openalex.org/W2036472115","https://openalex.org/W2036759594","https://openalex.org/W2041647537","https://openalex.org/W2045873742","https://openalex.org/W2048301069","https://openalex.org/W2049472311","https://openalex.org/W2051507092","https://openalex.org/W2052172628","https://openalex.org/W2054477373","https://openalex.org/W2060656177","https://openalex.org/W2060715078","https://openalex.org/W2061767433","https://openalex.org/W2065550467","https://openalex.org/W2072815966","https://openalex.org/W2085562312","https://openalex.org/W2089324437","https://openalex.org/W2092663627","https://openalex.org/W2099780759","https://openalex.org/W2100831525","https://openalex.org/W2103405817","https://openalex.org/W2107160489","https://openalex.org/W2110244190","https://openalex.org/W2113314239","https://openalex.org/W2114098415","https://openalex.org/W2120157356","https://openalex.org/W2122798447","https://openalex.org/W2123213425","https://openalex.org/W2127203245","https://openalex.org/W2129536790","https://openalex.org/W2135757997","https://openalex.org/W2136554322","https://openalex.org/W2141397996","https://openalex.org/W2141914435","https://openalex.org/W2144703255","https://openalex.org/W2147854094","https://openalex.org/W2150773437","https://openalex.org/W2153611368","https://openalex.org/W2157764570","https://openalex.org/W2158558333","https://openalex.org/W2163981817","https://openalex.org/W2168736535","https://openalex.org/W2168858690","https://openalex.org/W2171416033","https://openalex.org/W2173560213","https://openalex.org/W2216225615","https://openalex.org/W2266864727","https://openalex.org/W2413122320","https://openalex.org/W2416676694","https://openalex.org/W4230082309","https://openalex.org/W4313347774"],"related_works":["https://openalex.org/W1961025500","https://openalex.org/W2112008193","https://openalex.org/W2148517299","https://openalex.org/W2021000047","https://openalex.org/W1983949301","https://openalex.org/W79033930","https://openalex.org/W2168858690","https://openalex.org/W2583163002","https://openalex.org/W2163053288","https://openalex.org/W2097034504"],"abstract_inverted_index":{"IL-4-mediated":[0],"proangiogenic":[1,216],"and":[2,29,109,130,136,161,228],"proinflammatory":[3],"vascular":[4,30,92],"responses":[5],"have":[6],"been":[7],"implicated":[8],"in":[9,82,99,115,133,142,173,181,185,189,202,209,218],"the":[10,32,38,51,56,100,134,188,219,225,233],"pathogenesis":[11],"of":[12,35,59,102,198,232],"chronic":[13],"lung":[14,156,174,220],"diseases":[15],"such":[16],"as":[17,119,146],"asthma.":[18],"Although":[19],"it":[20],"is":[21,230],"well":[22],"known":[23],"that":[24,75,208],"hypoxia":[25,76,89],"induces":[26],"pulmonary":[27,39,62,128,137,200],"angiogenesis":[28,63,129,201],"alterations,":[31],"underlying":[33],"mechanism":[34],"IL-4":[36,60,68,116,143,177,214],"on":[37],"vasculature":[40],"under":[41,64,221],"hypoxic":[42,65,222],"conditions":[43,66,223],"remains":[44],"unknown.":[45],"In":[46,125,212],"this":[47,229],"context,":[48],"we":[49,193],"designed":[50],"present":[52],"study":[53],"to":[54,207],"determine":[55],"functional":[57],"importance":[58],"for":[61],"using":[67],"knockout":[69],"(KO)":[70],"animals.":[71],"Our":[72],"results":[73,183],"show":[74],"significantly":[77,90,113,140,171],"increased":[78],"IL-4R":[79],"alpha":[80],"expression":[81,98],"wild-type":[83],"(WT)":[84],"control":[85,123,150],"lungs.":[86,124,151],"Even":[87],"though":[88],"up-regulated":[91],"endothelial":[93],"growth":[94],"factor":[95],"(VEGF)":[96],"receptor":[97],"lungs":[101,118,145],"both":[103],"genotypes,":[104],"hypoxia-induced":[105,127,199],"VEGF,":[106],"VCAM-1,":[107],"HIF-1alpha,":[108],"ERK":[110],"phosphorylation":[111],"were":[112,139],"diminished":[114],"KO":[117,144,178,204],"compared":[120,147],"with":[121,148,165,187],"WT":[122,149,210],"addition,":[126],"proliferating":[131],"activities":[132],"airway":[135],"artery":[138],"suppressed":[141,172],"We":[152],"also":[153],"isolated":[154],"primary":[155],"fibroblasts":[157,175],"from":[158,176],"these":[159,163],"genotypes":[160],"stimulated":[162],"cells":[164],"hypoxia.":[166],"Hypoxia-induced":[167],"VEGF":[168,226],"production":[169],"was":[170],"mice.":[179],"These":[180],"vitro":[182],"are":[184],"accordance":[186],"vivo":[190],"data.":[191],"Furthermore,":[192],"observed":[194],"a":[195],"significant":[196],"increase":[197],"STAT6":[203,234],"mice":[205],"similar":[206],"controls.":[211],"conclusion,":[213],"has":[215],"properties":[217],"via":[224],"pathway,":[227],"independent":[231],"pathway.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}