{"id":"https://openalex.org/W1490036244","doi":null,"title":"Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB.","display_name":"Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W1490036244","mag":"1490036244","pmid":"https://pubmed.ncbi.nlm.nih.gov/10798647"},"language":"en","primary_location":{"id":"pmid:10798647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10798647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058413340","display_name":"Rajiv R. Mohan","orcid":"https://orcid.org/0000-0002-1857-4200","observed_orcids":["https://orcid.org/0000-0002-1857-4200"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R R Mohan","raw_affiliation_strings":["Department of Ophthalmology, University of Washington School of Medicine, Seattle, USA","Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","From the Department of Ophthalmology, University of Washington School of Medicine, Seattle; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Washington School of Medicine, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"From the Department of Ophthalmology, University of Washington School of Medicine, Seattle; the","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043319025","display_name":"Rahul R. Mohan","orcid":"https://orcid.org/0000-0002-5503-1686","observed_orcids":["https://orcid.org/0000-0002-5503-1686"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R R Mohan","raw_affiliation_strings":["Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","From the Department of Ophthalmology, University of Washington School of Medicine, Seattle; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"From the Department of Ophthalmology, University of Washington School of Medicine, Seattle; the","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073850293","display_name":"Woo Jung Kim","orcid":"https://orcid.org/0000-0002-4963-4819","observed_orcids":["https://orcid.org/0000-0002-4963-4819"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"W J Kim","raw_affiliation_strings":["Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","Department of Ophthalmology, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Ophthalmology, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010475533","display_name":"Steven E. Wilson","orcid":"https://orcid.org/0000-0001-8121-960X","observed_orcids":["https://orcid.org/0000-0001-8121-960X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S E Wilson","raw_affiliation_strings":["Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","From the Department of Ophthalmology, University of Washington School of Medicine, Seattle; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Eye Institute, The Cleveland Clinic Foundation, Ohio; and the","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"From the Department of Ophthalmology, University of Washington School of Medicine, Seattle; the","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5382,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.89251856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"41","issue":"6","first_page":"1327","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/corneal-fibroblasts","display_name":"corneal fibroblasts","score":0.996999979019165},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.843999981880188},{"id":"https://openalex.org/keywords/tnf-receptor-2","display_name":"TNF receptor 2","score":1.0},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.7490000128746033},{"id":"https://openalex.org/keywords/sn50","display_name":"SN50","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ketorolac-tromethamine","display_name":"ketorolac tromethamine","score":0.9480000138282776},{"id":"https://openalex.org/keywords/diclofenac-sodium","display_name":"diclofenac sodium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.7519999742507935},{"id":"https://openalex.org/keywords/corneal-stroma","display_name":"corneal stroma","score":0.7919999957084656},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.6349999904632568},{"id":"https://openalex.org/keywords/corneal-stromal-fibroblasts","display_name":"corneal stromal fibroblasts","score":0.5600000023841858},{"id":"https://openalex.org/keywords/corneal-epithelial-cells","display_name":"corneal epithelial cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.5400000214576721},{"id":"https://openalex.org/keywords/corneal-transplantation","display_name":"corneal transplantation","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7424535751342773},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.6522788405418396},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.6171472072601318},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5667172074317932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5513132810592651},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5209951996803284},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4957321882247925},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2870051860809326},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.26469680666923523},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19750115275382996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09562462568283081},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047889","descriptor_name":"Receptors, Tumor Necrosis Factor, Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10798647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10798647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.215","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.215","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/41/6/1327.full.pdf","raw_type":"text"},{"id":"mag:1490036244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10798647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8823200484","display_name":"Corneal Epithelial Growth Factors and Receptors","funder_award_id":"R01EY010056","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W184962058","https://openalex.org/W205405704","https://openalex.org/W1492606093","https://openalex.org/W1504388077","https://openalex.org/W1522773084","https://openalex.org/W1562090983","https://openalex.org/W1566297042","https://openalex.org/W1570707523","https://openalex.org/W1717444875","https://openalex.org/W1873458020","https://openalex.org/W1888783223","https://openalex.org/W1939922918","https://openalex.org/W1966684193","https://openalex.org/W1966783301","https://openalex.org/W1970625951","https://openalex.org/W1973597907","https://openalex.org/W1976570855","https://openalex.org/W1978018492","https://openalex.org/W1982062664","https://openalex.org/W1984113136","https://openalex.org/W1991581560","https://openalex.org/W1992045438","https://openalex.org/W2002507218","https://openalex.org/W2004897289","https://openalex.org/W2005484362","https://openalex.org/W2008058658","https://openalex.org/W2010237936","https://openalex.org/W2026190640","https://openalex.org/W2031089158","https://openalex.org/W2057123987","https://openalex.org/W2061867766","https://openalex.org/W2064032763","https://openalex.org/W2065257477","https://openalex.org/W2067680656","https://openalex.org/W2068467639","https://openalex.org/W2070762401","https://openalex.org/W2073993982","https://openalex.org/W2081191421","https://openalex.org/W2081687035","https://openalex.org/W2082575834","https://openalex.org/W2091136488","https://openalex.org/W2096970017","https://openalex.org/W2101620850","https://openalex.org/W2114291961","https://openalex.org/W2128635872","https://openalex.org/W2129889907","https://openalex.org/W2151892297","https://openalex.org/W2168827678","https://openalex.org/W2329115453","https://openalex.org/W2415210102","https://openalex.org/W2415499460","https://openalex.org/W2416135791","https://openalex.org/W2417027944"],"related_works":["https://openalex.org/W7099715613","https://openalex.org/W2032125458","https://openalex.org/W2005441602","https://openalex.org/W2093279419","https://openalex.org/W2080516682","https://openalex.org/W2088394439","https://openalex.org/W1989102627","https://openalex.org/W153879847","https://openalex.org/W2144224588","https://openalex.org/W2372945948"],"abstract_inverted_index":{"PURPOSE:":[0],"Previous":[1],"studies":[2],"have":[3,23],"suggested":[4],"no":[5],"role":[6,58],"for":[7],"tumor":[8],"necrosis":[9],"factor":[10,27,61],"(TNF)-alpha":[11],"in":[12,17,47,63,106,112,175,183,195,220,227,236,285,290,310,332,357],"the":[13,42,57,64,117,207,286,291,311,321,333],"modulation":[14],"of":[15,45,51,59,66,69,116,120,293,302,308,313,342],"apoptosis":[16,68,356],"corneal":[18,70,107,179,186,198,200,224,229,239,242,257,344,354],"fibroblasts.":[19,71],"However,":[20],"recent":[21],"investigations":[22],"demonstrated":[24],"that":[25,36],"nuclear":[26],"(NF)-kappaB":[28],"activation":[29,147,157,263,337],"by":[30,76,89,101,139,218,304,320],"TNF-alpha":[31,46,111,190,231,255,305,327],"mediates":[32],"negative":[33],"apoptotic":[34,43],"effects":[35,44],"must":[37],"be":[38],"blocked":[39,265],"to":[40,55,359],"unmask":[41],"vitro.":[48],"The":[49,326],"purpose":[50],"this":[52],"study":[53],"was":[54,74,99,137,158,192,233,264,274],"investigate":[56],"transcription":[60],"NF-kappaB":[62,121,262,336],"suppression":[65,307],"TNF-alpha-induced":[67],"METHODS:":[72],"mRNA":[73,191],"detected":[75,88,174,194,217,235],"reverse":[77],"transcription-polymerase":[78],"chain":[79],"reaction":[80],"(RT-PCR)":[81],"and":[82,91,152,170,182,203,213,245,251,306,335],"RNase":[83,208],"protection":[84,209],"assay.":[85,164,210],"Proteins":[86],"were":[87,173,216],"immunocytochemistry":[90,219],"immunoprecipitation":[92,250],"with":[93,110,129,206,266,276],"Western":[94,252],"blot":[95,253],"analysis.":[96,254],"Cell":[97],"death":[98,260,273],"evaluated":[100],"trypan":[102,140],"blue":[103,141],"exclusion":[104],"assay":[105,299],"fibroblasts":[108,205,248],"treated":[109],"presence":[113,312],"or":[114,126,133,269,280,316,350],"absence":[115],"specific":[118],"inhibitor":[119],"activation,":[122],"SN50,":[123,317],"actinomycin":[124,127,267,294,314],"D,":[125],"D":[128,268,315],"dexamethasone,":[130,277],"ketorolac":[131,278],"tromethamine,":[132,279],"diclofenac":[134,281],"sodium.":[135],"Apoptosis":[136],"monitored":[138,159],"exclusion,":[142],"colorimetric":[143],"cell":[144,180,225,259,272],"assay,":[145,148,151],"CPP32":[146],"DNA":[149],"fragmentation":[150],"transmission":[153],"electron":[154],"microscopy.":[155],"NF-KB":[156,303],"using":[160,188,249],"electrophoretic":[161],"gel":[162,297],"shift":[163,298],"RESULTS:":[165],"TNF-alpha,":[166,211],"TNF":[167],"receptor":[168,328],"(R)I,":[169],"TNFRII":[171,214],"mRNAs":[172],"all":[176,221],"three":[177,222],"cultured":[178],"types":[181,226],"ex":[184,196,237],"vivo":[185,197,238],"epithelium":[187],"RT-PCR.":[189],"also":[193,234],"epithelium,":[199,240],"epithelial":[201,243],"cells,":[202,244],"stromal":[204,247],"TNFRI,":[212],"proteins":[215],"major":[223],"human":[228],"tissue.":[230],"protein":[232],"primary":[241,246],"stimulated":[256],"fibroblast":[258,345,355],"when":[261,283],"SN50.":[270],"Enhanced":[271],"noted":[275],"sodium":[282],"used":[284],"presence,":[287],"but":[288,318],"not":[289,319],"absence,":[292],"D.":[295],"A":[296],"revealed":[300],"induction":[301,309],"control":[322],"peptide":[323],"SN50M.":[324],"CONCLUSIONS:":[325],"system":[329],"is":[330,338],"expressed":[331],"cornea,":[334],"an":[339],"important":[340],"regulator":[341],"TNF-alpha-mediated":[343],"apoptosis.":[346],"Nonsteroidal":[347],"anti-inflammatory":[348],"agents":[349],"corticosteroids":[351],"may":[352],"potentiate":[353],"response":[358],"cytokine":[360],"stimulation.":[361]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
