{"id":"https://openalex.org/W1489775899","doi":null,"title":"Effects of various oxygenation conditions on the enhancement by Fluosol-DA of melphalan antitumor activity.","display_name":"Effects of various oxygenation conditions on the enhancement by Fluosol-DA of melphalan antitumor activity.","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W1489775899","mag":"1489775899","pmid":"https://pubmed.ncbi.nlm.nih.gov/3113727"},"language":"en","primary_location":{"id":"pmid:3113727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3113727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040137655","display_name":"Beverly A. Teicher","orcid":"https://orcid.org/0000-0003-1535-7304","observed_orcids":["https://orcid.org/0000-0003-1535-7304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Teicher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007506005","display_name":"James M. Crawford","orcid":"https://orcid.org/0000-0002-8581-1093","observed_orcids":["https://orcid.org/0000-0002-8581-1093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Crawford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108530357","display_name":"Sylvia A. Holden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Holden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073138190","display_name":"Kathleen N. S. Cathcart","orcid":"https://orcid.org/0000-0001-7600-6001","observed_orcids":["https://orcid.org/0000-0001-7600-6001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K N Cathcart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5184,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.79459744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"47","issue":"19","first_page":"5036","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fluosol-da","display_name":"Fluosol-DA","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hyperbaric-oxygen-therapy","display_name":"hyperbaric oxygen therapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/carbogen-breathing","display_name":"carbogen breathing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5870000123977661},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dna-crosslinks","display_name":"DNA cross-links","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6880000233650208},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/spleen-toxicity","display_name":"spleen toxicity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.6489999890327454},{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.6489999890327454},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.9869072437286377},{"id":"https://openalex.org/C2776495794","wikidata":"https://www.wikidata.org/wiki/Q1362453","display_name":"Fibrosarcoma","level":2,"score":0.7333104610443115},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.4380732774734497},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4361982047557831},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43331652879714966},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.35618528723716736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2784326672554016},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.21148157119750977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17830020189285278},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16419360041618347},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14888429641723633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11672231554985046}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006895","descriptor_name":"Hydroxyethyl Starch Derivatives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3113727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3113727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1489775899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3113727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2487053515","display_name":"HEPATIC DIPOSITION OF BILIRUBIN AND ITS GLUCDRONIDES","funder_award_id":"F32DK007502","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4433811956","display_name":"CLINICAL/EXPERIMENTAL PHARMACOLOGY OF RESPIRATORY CANCER","funder_award_id":"P01CA019589","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5664952114","display_name":"CYTOTOXICTY AND MECHANISM OF PLATINUM ANTITUMOR AGENTS","funder_award_id":"F32CA007821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063809052","https://openalex.org/W2141889200","https://openalex.org/W1982767439","https://openalex.org/W2007032949","https://openalex.org/W2164113760","https://openalex.org/W139044897","https://openalex.org/W2165577559","https://openalex.org/W2419567737","https://openalex.org/W2213140790","https://openalex.org/W2342634230"],"abstract_inverted_index":{"The":[0,217,275],"cytotoxicity":[1],"of":[2,26,37,42,52,94,108,120,150,202,207,219,277,348,356,374],"melphalan":[3,55,76,114,137,161,203,224,234,357],"toward":[4,59],"exponentially":[5],"growing":[6],"FSaIIC":[7,38,69,110,182],"fibrosarcoma":[8,111,183],"cells":[9,20,39,70,292],"under":[10,40,77,117,238,257],"hypoxia,":[11],"normal":[12,363,377],"aeration,":[13],"hyperoxygenation,":[14],"and":[15,49,85,189,235,265,289,345],"stationary":[16],"phase":[17],"normally":[18,60,101],"oxygenated":[19,102],"was":[21,32,56,66,153,193,244,380],"examined.":[22],"Through":[23],"4":[24,305,322],"logs":[25,51],"cell":[27,53,191,209,231],"kill":[28,210,232],"by":[29,136,160,195,303,320],"melphalan,":[30,188],"there":[31,152],"no":[33],"difference":[34],"in":[35,68,99,156,198,211,249,326,336,362],"survival":[36,192],"any":[41],"the":[43,47,78,91,100,109,131,148,239,278,313,332,337,353,368,372,375],"four":[44,118],"conditions.":[45,242],"In":[46,342],"fifth":[48],"sixth":[50],"kill,":[54],"most":[57],"cytotoxic":[58],"aerated":[61],"cells.":[62,103],"DNA":[63,95],"alkaline":[64],"elution":[65,84],"performed":[67,116],"treated":[71,112,186],"for":[72],"1":[73,227,271,297,317,346],"h":[74,347],"with":[75,113,166,173,187,223,299,331,339],"various":[79,240,282],"atmospheres.":[80],"Both":[81],"upon":[82],"immediate":[83,288],"after":[86],"a":[87,212,246,300,359],"6-h":[88],"delay":[89,106,134,159],"period":[90],"greatest":[92],"number":[93,334],"cross-links":[96],"were":[97,115,185,293,309,323],"formed":[98],"Tumor":[104],"growth":[105,133,158],"studies":[107],"levels":[119,206],"oxygenation.":[121],"From":[122],"air":[123,167,236],"breathing":[124,168,237,261,350],"to":[125,143,169,221,251,280,286],"100%":[126,174],"oxygen":[127,175],"at":[128,176],"3":[129,141,177,273],"atm,":[130],"tumor":[132,157,190,208,230],"produced":[135,204,225],"increased":[138,325,371],"from":[139,162,312],"about":[140,144,163,170],"days":[142,165,172],"9":[145],"days.":[146],"With":[147],"addition":[149,218],"Fluosol-DA,":[151,330],"an":[154],"increase":[155,248,361],"6.5":[164],"13":[171],"atm":[178],"(1":[179],"h).":[180],"When":[181],"tumors":[184],"measured":[194],"colony":[196],"formation":[197],"culture,":[199],"increasing":[200,205,367],"doses":[201],"relatively":[213],"log":[214,228],"linear":[215],"manner.":[216],"Fluosol-DA":[220,344],"treatment":[222,283,327],"approximately":[226,245],"greater":[229],"than":[233],"oxygenation":[241,267,369],"There":[243],"4-fold":[247],"toxicity":[250,379],"bone":[252],"marrow":[253],"granulocyte-macrophage":[254],"colony-forming":[255],"units":[256],"both":[258],"extended":[259],"carbogen":[260,349],"conditions":[262,268],"(6":[263],"h)":[264],"hyperbaric":[266],"(100%":[269],"oxygen,":[270],"h,":[272],"atm).":[274],"response":[276,373],"spleen":[279],"these":[281],"regimens":[284],"appeared":[285],"be":[287],"shortlived.":[290],"Necrotic":[291],"seen":[294,335],"on":[295,315],"day":[296,304,316,321],"posttreatment,":[298,318],"substantial":[301],"reduction":[302],"posttreatment.":[306],"Mitotic":[307],"figures":[308],"essentially":[310],"absent":[311],"liver":[314],"but":[319],"significantly":[324,351],"groups":[328],"receiving":[329],"largest":[333],"melphalan/Fluosol-DA":[338],"carbogen-breathing":[340],"group.":[341],"conclusion,":[343],"increases":[352],"antitumor":[354],"activity":[355],"without":[358],"concomitant":[360],"tissue":[364,378],"toxicity.":[365],"Although":[366],"level":[370],"tumor,":[376],"also":[381],"increased.":[382]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}