{"id":"https://openalex.org/W1489588461","doi":"https://doi.org/10.1128/jb.176.8.2326-2338.1994","title":"Role of the TonB amino terminus in energy transduction between membranes","display_name":"Role of the TonB amino terminus in energy transduction between membranes","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W1489588461","doi":"https://doi.org/10.1128/jb.176.8.2326-2338.1994","mag":"1489588461","pmid":"https://pubmed.ncbi.nlm.nih.gov/8157601","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/205356"},"language":"en","primary_location":{"id":"doi:10.1128/jb.176.8.2326-2338.1994","doi":"https://doi.org/10.1128/jb.176.8.2326-2338.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.176.8.2326-2338.1994","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/205356","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008911922","display_name":"J C Jaskula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C Jaskula","raw_affiliation_strings":["Department of Microbiology, Washington State University, Pullman 99164-4233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Washington State University, Pullman 99164-4233","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085921470","display_name":"Tracy E. Letain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T E Letain","raw_affiliation_strings":["Department of Microbiology, Washington State University, Pullman 99164-4233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Washington State University, Pullman 99164-4233","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090494332","display_name":"S K Roof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S K Roof","raw_affiliation_strings":["Department of Microbiology, Washington State University, Pullman 99164-4233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Washington State University, Pullman 99164-4233","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067154316","display_name":"Jon T. Skare","orcid":"https://orcid.org/0000-0001-8378-7862","observed_orcids":["https://orcid.org/0000-0001-8378-7862"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J T Skare","raw_affiliation_strings":["Department of Microbiology, Washington State University, Pullman 99164-4233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Washington State University, Pullman 99164-4233","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055157480","display_name":"Kathleen Postle","orcid":"https://orcid.org/0000-0001-9451-777X","observed_orcids":["https://orcid.org/0000-0001-9451-777X"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Postle","raw_affiliation_strings":["Department of Microbiology, Washington State University, Pullman 99164-4233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Washington State University, Pullman 99164-4233","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":null,"apc_paid":null,"fwci":4.0013,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.94159879,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"176","issue":"8","first_page":"2326","last_page":"2338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tonb","display_name":"TonB","score":0.9309999942779541},{"id":"https://openalex.org/keywords/energy-transduction","display_name":"energy transduction","score":0.824999988079071},{"id":"https://openalex.org/keywords/outer-membrane-transport","display_name":"outer membrane transport","score":0.6740000247955322},{"id":"https://openalex.org/keywords/exbb","display_name":"ExbB","score":0.6869999766349792},{"id":"https://openalex.org/keywords/teta","display_name":"tetA","score":0.7329999804496765},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.5130000114440918},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.886436939239502},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.6877651810646057},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5766811966896057},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5281165838241577},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5069832801818848},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42400062084198},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3715146481990814}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.176.8.2326-2338.1994","doi":"https://doi.org/10.1128/jb.176.8.2326-2338.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.176.8.2326-2338.1994","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:205356","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/205356","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:8157601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8157601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:205356","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/205356","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2097708080","display_name":null,"funder_award_id":"GM 42146","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5188402618","display_name":"Energy Transduction Between Membranes","funder_award_id":"R01GM042146","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W198354287","https://openalex.org/W205412000","https://openalex.org/W1500012431","https://openalex.org/W1520794681","https://openalex.org/W1522265835","https://openalex.org/W1531405061","https://openalex.org/W1540087287","https://openalex.org/W1540348039","https://openalex.org/W1543392740","https://openalex.org/W1546783991","https://openalex.org/W1562400216","https://openalex.org/W1577100808","https://openalex.org/W1578241902","https://openalex.org/W1581821440","https://openalex.org/W1700511580","https://openalex.org/W1751864398","https://openalex.org/W1775602440","https://openalex.org/W1893684462","https://openalex.org/W1907864415","https://openalex.org/W1910394702","https://openalex.org/W1912992879","https://openalex.org/W1933977245","https://openalex.org/W1982738606","https://openalex.org/W1982939568","https://openalex.org/W1993896887","https://openalex.org/W2000101353","https://openalex.org/W2016556161","https://openalex.org/W2018289835","https://openalex.org/W2028552201","https://openalex.org/W2028848361","https://openalex.org/W2036104155","https://openalex.org/W2038605297","https://openalex.org/W2042814467","https://openalex.org/W2047671583","https://openalex.org/W2078959666","https://openalex.org/W2083225580","https://openalex.org/W2083547997","https://openalex.org/W2090247075","https://openalex.org/W2095506983","https://openalex.org/W2100837269","https://openalex.org/W2102101377","https://openalex.org/W2112127855","https://openalex.org/W2119909490","https://openalex.org/W2122400865","https://openalex.org/W2125882807","https://openalex.org/W2127113394","https://openalex.org/W2148408340"],"related_works":["https://openalex.org/W198354287","https://openalex.org/W1578241902","https://openalex.org/W1965600386","https://openalex.org/W2060472654","https://openalex.org/W2936242996","https://openalex.org/W2122400865","https://openalex.org/W1540348039","https://openalex.org/W1546174188","https://openalex.org/W816601681","https://openalex.org/W2028552201"],"abstract_inverted_index":{"Escherichia":[0],"coli":[1],"TonB":[2,24,81,100,104,108,119,145,155,196,220,226],"protein":[3,96],"is":[4,25,123,186,208,213],"an":[5,74,147],"energy":[6,11],"transducer,":[7],"coupling":[8],"cytoplasmic":[9,29,94,172,224,238],"membrane":[10,30,95,162,210,230],"to":[12,121,168,179,191],"active":[13],"transport":[14],"of":[15,55,66,80,87,92,140,144,170],"vitamin":[16],"B12":[17],"and":[18,173,176],"iron-siderophores":[19],"across":[20],"the":[21,28,37,40,51,61,70,83,88,93,99,112,128,141,171,183,204,215,223,237],"outer":[22,174],"membrane.":[23,225,239],"anchored":[26],"in":[27,60],"by":[31,218],"its":[32,228],"hydrophobic":[33,52],"amino":[34,53,62,71,101,113,142,184,205],"terminus,":[35],"with":[36,160,194,222,236],"remainder":[38],"occupying":[39],"periplasmic":[41],"space.":[42],"In":[43,137,181],"this":[44],"report":[45],"we":[46],"establish":[47],"several":[48],"functions":[49],"for":[50,77,98,189],"terminus":[54,63,72,102,114,143,185,206],"TonB.":[56],"A":[57],"G-26-->D":[58],"substitution":[59],"prevents":[64],"export":[65,75],"TonB,":[67],"suggesting":[68,110,126],"that":[69,111,127],"contains":[73,115],"signal":[76],"proper":[78],"localization":[79],"within":[82],"cell":[84],"envelope.":[85],"Substitution":[86],"first":[89],"membrane-spanning":[90],"domain":[91],"TetA":[97],"eliminates":[103,153],"activity":[105],"without":[106],"altering":[107],"export,":[109],"sequence-specific":[116],"information.":[117],"Detectable":[118],"cross-linking":[120,178,190],"ExbB":[122],"also":[124],"prevented,":[125],"two":[129],"proteins":[130,193],"interact":[131],"primarily":[132],"through":[133],"their":[134],"transmembrane":[135],"domains.":[136],"vivo":[138],"cleavage":[139,151],"carrying":[146],"engineered":[148],"leader":[149],"peptidase":[150],"site":[152],"(i)":[154],"activity,":[156],"(ii)":[157],"detectable":[158],"interaction":[159],"a":[161,165,209],"fraction":[163],"having":[164],"density":[166],"intermediate":[167],"those":[169],"membranes,":[175],"(iii)":[177],"ExbB.":[180],"contrast,":[182],"not":[187,214],"required":[188],"other":[192],"which":[195,219],"can":[197],"form":[198],"complexes,":[199],"including":[200],"FepA.":[201],"Additionally,":[202],"although":[203],"clearly":[207],"anchor,":[211],"it":[212],"only":[216],"means":[217],"associates":[221],"lacking":[227],"amino-terminal":[229],"anchor":[231],"still":[232],"remains":[233],"largely":[234],"associated":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}