{"id":"https://openalex.org/W1489330398","doi":"https://doi.org/10.4049/jimmunol.169.7.3480","title":"Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with Mycobacterium tuberculosis","display_name":"Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with Mycobacterium tuberculosis","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W1489330398","doi":"https://doi.org/10.4049/jimmunol.169.7.3480","mag":"1489330398","pmid":"https://pubmed.ncbi.nlm.nih.gov/12244136"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.169.7.3480","doi":"https://doi.org/10.4049/jimmunol.169.7.3480","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.7.3480","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/7/3480/1157403/3480.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/169/7/3480/1157403/3480.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032712543","display_name":"Norbert Reiling","orcid":"https://orcid.org/0000-0001-6673-4291","observed_orcids":["https://orcid.org/0000-0001-6673-4291"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Norbert Reiling","raw_affiliation_strings":["Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080381047","display_name":"Christoph H\u00f6lscher","orcid":"https://orcid.org/0000-0002-7520-9146","observed_orcids":["https://orcid.org/0000-0002-7520-9146"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Ho\u0308lscher","raw_affiliation_strings":["Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019657314","display_name":"Alexandra Fehrenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alexandra Fehrenbach","raw_affiliation_strings":["Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090237481","display_name":"Svenja Kr\u00f6ger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Svenja Kro\u0308ger","raw_affiliation_strings":["Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107062996","display_name":"Carsten J. Kirschning","orcid":"https://orcid.org/0000-0003-2676-0940","observed_orcids":["https://orcid.org/0000-0003-2676-0940"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten J Kirschning","raw_affiliation_strings":["Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich , Munich ,","\u2020Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich , Munich ,","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"\u2020Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany; and","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029107831","display_name":"Sanna M. Goyert","orcid":"https://orcid.org/0000-0002-0994-7757","observed_orcids":["https://orcid.org/0000-0002-0994-7757"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanna Goyert","raw_affiliation_strings":["\u2021Division of Molecular Medicine, Cornell University Medical College, Manhasset, NY 11030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Division of Molecular Medicine, Cornell University Medical College, Manhasset, NY 11030","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111898729","display_name":"Stefan Ehlers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Ehlers","raw_affiliation_strings":["Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Infection Biology, Research Center Borstel , Borstel ,","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"*Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;","institution_ids":["https://openalex.org/I4210128097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019657314","https://openalex.org/A5032712543","https://openalex.org/A5111898729"],"corresponding_institution_ids":["https://openalex.org/I4210128097"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":20.9495,"has_fulltext":true,"cited_by_count":465,"citation_normalized_percentile":{"value":0.99627048,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"169","issue":"7","first_page":"3480","last_page":"3484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":1.0},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7009999752044678},{"id":"https://openalex.org/keywords/aerosol-infection","display_name":"aerosol infection","score":0.8050000071525574},{"id":"https://openalex.org/keywords/granuloma-formation","display_name":"granuloma formation","score":0.906000018119812},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tlr2-deficient-mice","display_name":"TLR2-deficient mice","score":0.5870000123977661},{"id":"https://openalex.org/keywords/tlr4-deficient-mice","display_name":"TLR4-deficient mice","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dose-dependent-susceptibility","display_name":"dose-dependent susceptibility","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.7755687832832336},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7581427097320557},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7066524624824524},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6601152420043945},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6399292349815369},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6211410760879517},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5618696808815002},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5555812120437622},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.5553575158119202},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5535686612129211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5030614733695984},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42819395661354065},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.4186059236526489},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3444802761077881},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3138028383255005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27419495582580566},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1237296462059021},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.169.7.3480","doi":"https://doi.org/10.4049/jimmunol.169.7.3480","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.7.3480","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/7/3480/1157403/3480.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12244136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12244136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.5452","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.5452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jimmunol.org/content/169/7/3480.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.169.7.3480","doi":"https://doi.org/10.4049/jimmunol.169.7.3480","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.7.3480","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/7/3480/1157403/3480.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1489330398.pdf","grobid_xml":"https://content.openalex.org/works/W1489330398.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W18521442","https://openalex.org/W1509377507","https://openalex.org/W1525912444","https://openalex.org/W1527612695","https://openalex.org/W1655860314","https://openalex.org/W1772719483","https://openalex.org/W1925757606","https://openalex.org/W1930598094","https://openalex.org/W1965640065","https://openalex.org/W1986648174","https://openalex.org/W1991109223","https://openalex.org/W1994646176","https://openalex.org/W1998380451","https://openalex.org/W2019255399","https://openalex.org/W2022159086","https://openalex.org/W2027657858","https://openalex.org/W2051686355","https://openalex.org/W2065791817","https://openalex.org/W2082649398","https://openalex.org/W2101594752","https://openalex.org/W2102578857","https://openalex.org/W2102888433","https://openalex.org/W2109938685","https://openalex.org/W2129319296","https://openalex.org/W2134338621","https://openalex.org/W2142602618","https://openalex.org/W2145078103","https://openalex.org/W2149349606","https://openalex.org/W2161273761","https://openalex.org/W2166422396","https://openalex.org/W2167059596"],"related_works":["https://openalex.org/W7099799937","https://openalex.org/W2129869755","https://openalex.org/W2159112596","https://openalex.org/W2074680101","https://openalex.org/W2108176428","https://openalex.org/W2133416903","https://openalex.org/W2102625516","https://openalex.org/W1965390251","https://openalex.org/W2122746019","https://openalex.org/W6999398066"],"abstract_inverted_index":{"Innate":[0],"resistance":[1,120],"against":[2,121,139],"Mycobacterium":[3],"tuberculosis":[4,28,50,98,123],"is":[5,144],"thought":[6],"to":[7,79,105,118],"depend":[8],"critically":[9],"on":[10,16],"engagement":[11],"of":[12,22,74,131],"pattern":[13],"recognition":[14],"receptors":[15,24],"macrophages.":[17],"However,":[18,90],"the":[19],"relative":[20],"contribution":[21],"these":[23],"for":[25],"containing":[26],"M.":[27,49,97,122],"infection":[29,54,82,143],"has":[30],"remained":[31],"unexplored":[32],"in":[33,43,77,85,124,135],"vivo.":[34],"To":[35],"address":[36],"this":[37],"issue,":[38],"we":[39],"infected":[40],"mice":[41,104],"defective":[42],"CD14,":[44],"TLR2,":[45],"or":[46],"TLR4":[47],"with":[48,55,94],"by":[51],"aerosol.":[52],"Following":[53],"100":[56],"mycobacteria,":[57],"either":[58],"mutant":[59,86],"strain":[60],"was":[61],"as":[62,64],"resistant":[63],"congenic":[65],"control":[66,88,110],"mice.":[67,89,111],"Granuloma":[68],"formation,":[69],"macrophage":[70],"activation,":[71],"and":[72,87,129,133],"secretion":[73],"proinflammatory":[75],"cytokines":[76],"response":[78],"low-dose":[80,141],"aerosol":[81,92],"were":[83],"identical":[84],"high-dose":[91],"challenge":[93],"2000":[95],"CFU":[96],"revealed":[99],"TLR2-,":[100],"but":[101],"not":[102],"TLR4-defective":[103],"be":[106],"more":[107],"susceptible":[108],"than":[109],"In":[112],"conclusion,":[113],"while":[114],"TLR2":[115],"signaling":[116],"contributes":[117],"innate":[119],"borderline":[125],"situations,":[126],"its":[127],"function,":[128],"that":[130],"CD14":[132],"TLR4,":[134],"initiating":[136],"protective":[137],"responses":[138],"naturally":[140],"airborne":[142],"redundant.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}