{"id":"https://openalex.org/W1487733209","doi":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","title":"Characterization of a pre-S polypeptide on the surfaces of infectious avian hepadnavirus particles","display_name":"Characterization of a pre-S polypeptide on the surfaces of infectious avian hepadnavirus particles","publication_year":1987,"publication_date":"1987-05-01","ids":{"openalex":"https://openalex.org/W1487733209","doi":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","mag":"1487733209","pmid":"https://pubmed.ncbi.nlm.nih.gov/2437317","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/254113"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.61.5.1384-1390.1987","doi":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","pdf_url":"https://jvi.asm.org/content/jvi/61/5/1384.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/61/5/1384.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037856327","display_name":"John C. Pugh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Pugh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074964557","display_name":"John J. Sninsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Sninsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108188026","display_name":"Jesse W. Summers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W Summers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060674227","display_name":"Eric Schaeffer","orcid":"https://orcid.org/0009-0008-3892-6163","observed_orcids":["https://orcid.org/0009-0008-3892-6163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Schaeffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1607,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.96188374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"61","issue":"5","first_page":"1384","last_page":"1390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duck-hepatitis-b-virus","display_name":"duck hepatitis B virus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pre-s-region","display_name":"pre-S region","score":0.8339999914169312},{"id":"https://openalex.org/keywords/viral-surface-proteins","display_name":"viral surface proteins","score":0.625},{"id":"https://openalex.org/keywords/carboxyl-terminal-sequence","display_name":"carboxyl-terminal sequence","score":0.5049999952316284},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.5590000152587891},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.7310000061988831},{"id":"https://openalex.org/keywords/fusion-protein-expression","display_name":"fusion protein expression","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8887503147125244},{"id":"https://openalex.org/C2777666129","wikidata":"https://www.wikidata.org/wiki/Q3503198","display_name":"Duck hepatitis B virus","level":5,"score":0.8737460374832153},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6629671454429626},{"id":"https://openalex.org/C2780730277","wikidata":"https://www.wikidata.org/wiki/Q24744759","display_name":"Chloramphenicol acetyltransferase","level":5,"score":0.6512809991836548},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6087539792060852},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.5690183639526367},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5300212502479553},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5256586670875549},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5206196308135986},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.4938703179359436},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4728926718235016},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.42555999755859375},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.42098289728164673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38028261065483093},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.3237988352775574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3188251554965973},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2686132490634918},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.23803627490997314},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.16810739040374756},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07977774739265442}],"mesh":[{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004372","descriptor_name":"Ducks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007158","descriptor_name":"Immunologic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.61.5.1384-1390.1987","doi":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","pdf_url":"https://jvi.asm.org/content/jvi/61/5/1384.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:254113","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/254113","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:2437317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2437317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.61.5.1384-1390.1987","doi":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.61.5.1384-1390.1987","pdf_url":"https://jvi.asm.org/content/jvi/61/5/1384.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2537673223","display_name":"TRAINING IN VIRAL ONCOLOGY AND TUMOR BIOLOGY","funder_award_id":"T32CA009060","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G921727105","display_name":null,"funder_award_id":"CA06927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G986930485","display_name":null,"funder_award_id":"RR-05539","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1487733209.pdf"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1467797602","https://openalex.org/W1483154651","https://openalex.org/W1546783991","https://openalex.org/W1574440685","https://openalex.org/W1751218746","https://openalex.org/W1845079004","https://openalex.org/W1850470548","https://openalex.org/W1931669582","https://openalex.org/W1948849533","https://openalex.org/W1978018263","https://openalex.org/W1984640298","https://openalex.org/W1989546700","https://openalex.org/W2017767695","https://openalex.org/W2018289835","https://openalex.org/W2022087413","https://openalex.org/W2022369173","https://openalex.org/W2063450941","https://openalex.org/W2084671891","https://openalex.org/W2089341748","https://openalex.org/W2095520922","https://openalex.org/W2095676524","https://openalex.org/W2100837269","https://openalex.org/W2113545773","https://openalex.org/W2122305232","https://openalex.org/W2143414604"],"related_works":["https://openalex.org/W1958302458","https://openalex.org/W1715270133","https://openalex.org/W2139676754","https://openalex.org/W1850470548","https://openalex.org/W1572160129","https://openalex.org/W2103693928","https://openalex.org/W63010256","https://openalex.org/W2040681367","https://openalex.org/W2042664959","https://openalex.org/W2008080478"],"abstract_inverted_index":{"DNA":[0],"from":[1,118],"the":[2,6,34,45,57,89,97,103,109,116,130,140,148,154],"pre-S":[3,47,149],"region":[4,150],"of":[5,39,44,53,81,139,156,166],"duck":[7],"hepatitis":[8],"B":[9],"virus":[10,141,167],"(DHBV)":[11],"genome":[12],"was":[13,66,85,125],"inserted":[14],"into":[15],"an":[16,143],"open":[17],"reading":[18],"frame":[19],"vector":[20],"designed":[21],"to":[22,68,168],"give":[23],"high-level":[24],"expression":[25],"in":[26,72,115,142,144,164],"Escherichia":[27],"coli.":[28],"The":[29],"resulting":[30],"fusion":[31],"protein":[32],"contained":[33],"first":[35],"8":[36],"amino":[37,42,51],"acids":[38,43,52],"beta-galactosidase,":[40],"86":[41],"DHBV":[46,73,104],"region,":[48],"and":[49,159],"219":[50],"chloramphenicol":[54],"acetyltransferase":[55],"at":[56],"C":[58],"terminus":[59],"(beta-gal:pre-S:CAT).":[60],"Rabbit":[61],"antiserum":[62],"against":[63,88],"purified":[64],"beta-gal:pre-S:CAT":[65],"used":[67],"identify":[69],"pre-S-containing":[70],"polypeptides":[71,107],"particles":[74],"by":[75],"Western":[76],"blotting.":[77],"A":[78],"dominant":[79],"species":[80],"36":[82],"kilodaltons":[83],"(kDa)":[84],"identified.":[86],"Antiserum":[87],"major":[90],"17-kDa":[91],"DHBsAg":[92],"polypeptide":[93],"also":[94],"reacted":[95],"with":[96],"36-kDa":[98,133],"protein.":[99],"This":[100],"suggests":[101],"that":[102],"envelope":[105,134],"gene":[106],"share":[108],"same":[110],"carboxyl":[111],"terminus,":[112],"but":[113],"differ":[114],"sites":[117],"which":[119],"translation":[120],"is":[121,151],"initiated.":[122],"N-linked":[123],"carbohydrate":[124],"not":[126],"detected":[127],"on":[128,153],"either":[129],"17-":[131],"or":[132],"proteins.":[135],"Anti-beta-gal:pre-S:CAT":[136],"abolished":[137],"infectivity":[138],"vitro":[145],"assay.":[146],"Thus,":[147],"exposed":[152],"surfaces":[155],"infectious":[157],"virions":[158],"may":[160],"be":[161],"directly":[162],"involved":[163],"binding":[165],"host-cell":[169],"receptors.":[170]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}