{"id":"https://openalex.org/W1487584072","doi":"https://doi.org/10.21236/ada409484","title":"Characterization of a Novel Tumor Suppressor Gene, mda-7, and its Ability to Induce Apoptosis","display_name":"Characterization of a Novel Tumor Suppressor Gene, mda-7, and its Ability to Induce Apoptosis","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1487584072","doi":"https://doi.org/10.21236/ada409484","mag":"1487584072"},"language":"en","primary_location":{"id":"doi:10.21236/ada409484","doi":"https://doi.org/10.21236/ada409484","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada409484","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091194969","display_name":"Devanand Sarkar","orcid":"https://orcid.org/0000-0003-0973-2323","observed_orcids":["https://orcid.org/0000-0003-0973-2323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devanand Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031490587","display_name":"Paul B. Fisher","orcid":"https://orcid.org/0000-0002-0085-4546","observed_orcids":["https://orcid.org/0000-0002-0085-4546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul B. Fisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.20389999449253082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mda-7","display_name":"MDA-7","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adenovirus-mediated-gene-therapy","display_name":"adenoviral gene therapy","score":0.699999988079071},{"id":"https://openalex.org/keywords/sb203580","display_name":"SB203580","score":0.8360000252723694},{"id":"https://openalex.org/keywords/antisense-inhibition","display_name":"antisense inhibition","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7322111129760742},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7168636322021484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6064988970756531},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5673959255218506},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5259987115859985},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45087146759033203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37164050340652466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3395249843597412},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33431389927864075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3138810992240906},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.09957098960876465}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21236/ada409484","doi":"https://doi.org/10.21236/ada409484","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada409484","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA409484","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA409484","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044943819","https://openalex.org/W2323327334","https://openalex.org/W7100501042","https://openalex.org/W1585683447","https://openalex.org/W2019072035","https://openalex.org/W2006569353","https://openalex.org/W2001401716","https://openalex.org/W2321501275","https://openalex.org/W2135615816","https://openalex.org/W1988470304"],"abstract_inverted_index":{"Subtraction":[0],"hybridization":[1],"identified":[2],"melanoma":[3,17],"differentiation":[4,14],"associated":[5],"gene-7":[6],"(mda-7)":[7],"as":[8],"a":[9,25,62,92,104],"gene":[10,117],"induced":[11,61],"during":[12],"terminal":[13],"in":[15,32,41,72,79,123,128,133,172,178],"human":[16,34],"cells.":[18,46,135,180],"Administration":[19],"of":[20,24,64,87,95,108,125,137,157,161,165,176],"mda-7":[21],"by":[22,140,163],"means":[23,164],"replication-incompetent":[26],"adenovirus":[27,102],"(Ad.mda-7)":[28],"induces":[29],"apoptosis":[30,114,177],"selectively":[31],"diverse":[33,73],"cancer":[35,74,129,179],"cells":[36,130],"without":[37],"inducing":[38],"harmful":[39],"effects":[40],"normal":[42,81,134],"fibroblast":[43],"or":[44],"epithelial":[45],"The":[47],"present":[48],"studies":[49],"investigated":[50],"the":[51,151,158,166,173],"mechanism":[52],"underlying":[53],"this":[54],"differential":[55],"apoptotic":[56],"effect.":[57],"Infection":[58],"with":[59,85,90,100],"Ad.mda-7":[60,120,154],"family":[63,118,160],"growth":[65],"arrest":[66],"and":[67,98,115],"DNA":[68],"damage":[69],"(GADD)-inducible":[70],"genes":[71,139,162],"cell":[75],"lines":[76],"but":[77,131],"not":[78,132],"their":[80],"counterparts,":[82],"which":[83],"correlated":[84],"induction":[86,156,175],"apoptosis.":[88,147],"Treatment":[89],"SB203580,":[91],"selective":[93,174],"inhibitor":[94,107],"p38":[96,109,126,167],"MAPK,":[97,110],"infection":[99,121],"an":[101,141],"expressing":[103],"dominant":[105],"negative":[106],"effectively":[111,144],"inhibited":[112],"Ad.mda-7-induced":[113,146],"GADD":[116,138,159],"induction.":[119],"resulted":[122],"phosphorylation":[124],"MAPK":[127,168],"Inhibition":[136],"antisense":[142],"approach":[143],"blocked":[145],"These":[148],"results":[149],"support":[150],"hypothesis":[152],"that":[153],"mediates":[155],"pathway,":[169],"thereby":[170],"resulting":[171]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}