{"id":"https://openalex.org/W1487569022","doi":"https://doi.org/10.1186/1471-2334-6-173","title":"Fluconazole for empiric antifungal therapy in cancer patients with fever and neutropenia","display_name":"Fluconazole for empiric antifungal therapy in cancer patients with fever and neutropenia","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W1487569022","doi":"https://doi.org/10.1186/1471-2334-6-173","mag":"1487569022","pmid":"https://pubmed.ncbi.nlm.nih.gov/17147804","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1702543"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2334-6-173","doi":"https://doi.org/10.1186/1471-2334-6-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-6-173","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-6-173","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-6-173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074649246","display_name":"Donghui Yu","orcid":"https://orcid.org/0000-0001-5360-6186","observed_orcids":["https://orcid.org/0000-0001-5360-6186"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donghui T Yu","raw_affiliation_strings":["Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. tyu1@partners.org <tyu1@partners.org>","Department of Information Systems, Partners HealthCare System, Boston, USA","Department of Medicine, Harvard Medical School, Boston, USA","Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. tyu1@partners.org <tyu1@partners.org>","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Information Systems, Partners HealthCare System, Boston, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027402430","display_name":"Diane L. Seger","orcid":"https://orcid.org/0000-0001-9924-378X","observed_orcids":["https://orcid.org/0000-0001-9924-378X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diane L Seger","raw_affiliation_strings":["Department of Information Systems, Partners HealthCare System, Boston, MA, USA","Department of Information Systems, Partners HealthCare System, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Systems, Partners HealthCare System, Boston, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Information Systems, Partners HealthCare System, Boston, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090773076","display_name":"Josh F. Peterson","orcid":"https://orcid.org/0000-0002-7553-0749","observed_orcids":["https://orcid.org/0000-0002-7553-0749"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh F Peterson","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN, USA","Vanderbilt University Medical Center Nashville USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt University Medical Center Nashville USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083240827","display_name":"Ritesh N. Kumar","orcid":"https://orcid.org/0000-0002-0982-6277","observed_orcids":["https://orcid.org/0000-0002-0982-6277"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritesh N Kumar","raw_affiliation_strings":["Outcomes Research, Merck & Co., Inc., Whitehouse Station, NJ, USA","Outcomes Research, Merck & Co, Inc, Whitehouse Station, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Outcomes Research, Merck & Co., Inc., Whitehouse Station, NJ, USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Outcomes Research, Merck & Co, Inc, Whitehouse Station, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036110536","display_name":"David Westfall Bates","orcid":"https://orcid.org/0000-0001-6268-1540","observed_orcids":["https://orcid.org/0000-0001-6268-1540","https://orcid.org/0000-0003-4850-2360","https://orcid.org/0000-0001-7438-9491","https://orcid.org/0000-0002-3105-156X","https://orcid.org/0000-0001-5440-6039"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David W Bates","raw_affiliation_strings":["Department of Information Systems, Partners HealthCare System, Boston, MA, USA","Department of Medicine, Harvard Medical School, Boston, MA, USA","Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA","Department of Information Systems, Partners HealthCare System, Boston, USA","Department of Medicine, Harvard Medical School, Boston, USA","Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Systems, Partners HealthCare System, Boston, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Information Systems, Partners HealthCare System, Boston, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036110536"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.08065599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"1","first_page":"173","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":1.0},{"id":"https://openalex.org/keywords/empiric-antifungal-therapy","display_name":"empirical antifungal therapy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.6119999885559082},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.6800000071525574},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9700000286102295},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.8679999709129333},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.8659999966621399},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8639768958091736},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.8563245534896851},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.8334673643112183},{"id":"https://openalex.org/C2779181126","wikidata":"https://www.wikidata.org/wiki/Q5374236","display_name":"Empiric therapy","level":3,"score":0.6490660905838013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6182919144630432},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5209128260612488},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.47717514634132385},{"id":"https://openalex.org/C2780558435","wikidata":"https://www.wikidata.org/wiki/Q3491700","display_name":"Fungemia","level":3,"score":0.43524879217147827},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4024737477302551},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36868178844451904},{"id":"https://openalex.org/C2780908437","wikidata":"https://www.wikidata.org/wiki/Q464067","display_name":"Mycosis","level":2,"score":0.2766258716583252},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23529881238937378},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.20830708742141724},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08107876777648926},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.06913414597511292},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2334-6-173","doi":"https://doi.org/10.1186/1471-2334-6-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-6-173","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-6-173","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1702543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1702543","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infect Dis","raw_type":"Text"},{"id":"pmid:17147804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17147804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC infectious diseases","raw_type":"Case Reports"},{"id":"pmh:oai:dash.harvard.edu:1/41426846","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41426846","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0aa1d93210aa4c9b84c4e2962ce226ec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0aa1d93210aa4c9b84c4e2962ce226ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Infectious Diseases, Vol 6, Iss 1, p 173 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2334-6-173","doi":"https://doi.org/10.1186/1471-2334-6-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-6-173","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-6-173","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1487569022.pdf","grobid_xml":"https://content.openalex.org/works/W1487569022.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W134773975","https://openalex.org/W1911188526","https://openalex.org/W1968632832","https://openalex.org/W1986330094","https://openalex.org/W1986506708","https://openalex.org/W1989277463","https://openalex.org/W1995945562","https://openalex.org/W2000445173","https://openalex.org/W2006530253","https://openalex.org/W2012050459","https://openalex.org/W2028387962","https://openalex.org/W2029714817","https://openalex.org/W2052285816","https://openalex.org/W2068893995","https://openalex.org/W2078654597","https://openalex.org/W2083121860","https://openalex.org/W2094616030","https://openalex.org/W2097394217","https://openalex.org/W2109850966","https://openalex.org/W2110643478","https://openalex.org/W2114208000","https://openalex.org/W2114509444","https://openalex.org/W2131920567","https://openalex.org/W2132472521","https://openalex.org/W2133328722","https://openalex.org/W2146052740","https://openalex.org/W2146558016","https://openalex.org/W2147723584","https://openalex.org/W2155029109","https://openalex.org/W2165970812","https://openalex.org/W2166858780","https://openalex.org/W2170019085","https://openalex.org/W2326799365","https://openalex.org/W3106889297","https://openalex.org/W4243217122","https://openalex.org/W4244351434","https://openalex.org/W4252230400","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2006530253","https://openalex.org/W2159760020","https://openalex.org/W2063975482","https://openalex.org/W4251907751","https://openalex.org/W2078654597","https://openalex.org/W2029604741","https://openalex.org/W7120295164","https://openalex.org/W2284279712","https://openalex.org/W134773975","https://openalex.org/W2401191685"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"clinical":[2,221],"trials":[3],"have":[4],"demonstrated":[5],"the":[6,26,176],"efficacy":[7],"of":[8,54,107,151,157,163,182,207],"fluconazole":[9,40,62,140,212],"as":[10,213],"empiric":[11,39,118,139,214],"antifungal":[12,41,141,215],"therapy":[13,42,110,119,142],"in":[14,35,43,67,144,180,203,219,225],"cancer":[15,36,55,77,129,209],"patients":[16,37,56,78,210],"with":[17,32,58,79,131,154],"fever":[18,89,132,218],"and":[19,28,65,88,133,184,193],"neutropenia.":[20],"Our":[21],"objective":[22],"was":[23],"to":[24,112,117],"assess":[25],"frequency":[27],"resource":[29],"utilization":[30],"associated":[31],"treatment":[33,135,164,173,216,228],"failure":[34,136,165,174,201,229],"given":[38],"routine":[44,220],"inpatient":[45],"care.":[46],"METHODS:":[47],"We":[48],"performed":[49],"a":[50,68,155],"retrospective":[51],"cohort":[52,75],"study":[53,74],"treated":[57],"oral":[59],"or":[60,96],"intravenous":[61],"between":[63],"7/97":[64],"6/01":[66],"tertiary":[69],"care":[70],"hospital.":[71],"The":[72,223],"final":[73],"included":[76],"neutropenia":[80],"(an":[81],"absolute":[82],"neutrophil":[83],"count":[84],"below":[85],"500":[86],"cells/mm3)":[87],"(a":[90],"temperature":[91],"above":[92],"38":[93],"degrees":[94,98],"C":[95],"100.4":[97],"F),":[99],"who":[100],"were":[101,120,187],"receiving":[102],"at":[103],"least":[104],"96":[105],"hours":[106],"parenteral":[108],"antibacterial":[109],"prior":[111],"initiating":[113,138],"fluconazole.":[114],"Patients'":[115],"responses":[116],"assessed":[121],"by":[122],"reviewing":[123],"patient":[124],"charts.":[125],"RESULTS:":[126],"Among":[127],"103":[128],"admissions":[130],"neutropenia,":[134],"after":[137],"occurred":[143,175,202],"41%":[145],"(95%":[146,190,195],"confidence":[147],"interval":[148],"(CI)":[149],"31%-50%)":[150],"admissions.":[152],"Patients":[153],"diagnosis":[156],"hematological":[158],"malignancy":[159],"had":[160],"increased":[161],"risk":[162],"(OR":[166],"=":[167],"4.6,":[168],"95%":[169],"CI":[170,191,196],"1.5-14.8).":[171],"When":[172],"mean":[177],"adjusted":[178],"increases":[179],"length":[181],"stay":[183],"total":[185],"costs":[186,226],"7.4":[188],"days":[189],"3.3-11.5)":[192],"$18,925":[194],"3,289-34,563),":[197],"respectively.":[198],"CONCLUSION:":[199],"Treatment":[200],"more":[204],"than":[205],"one-third":[206],"neutropenic":[208],"on":[211],"for":[217],"treatment.":[222],"increase":[224],"when":[227],"occurs":[230],"is":[231],"substantial.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}