{"id":"https://openalex.org/W148753030","doi":null,"title":"MCP-1 and APP involvement in glial differentiation and migration of neuroprogenitor cells","display_name":"MCP-1 and APP involvement in glial differentiation and migration of neuroprogenitor cells","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W148753030","mag":"148753030"},"language":"en","primary_location":{"id":"pmh:oai:stars.library.ucf.edu:etd-4823","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/3823","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://stars.library.ucf.edu/etd/3823","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070914635","display_name":"Emmanuel George Vrotsos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emmanuel George Vrotsos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070914635"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nt2-cells","display_name":"NT2 cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glial-differentiation","display_name":"glial differentiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.828000009059906},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8539999723434448},{"id":"https://openalex.org/keywords/jak-signaling","display_name":"JAK signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.6959999799728394},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/central-nervous-system-injury","display_name":"central nervous system injury","score":0.7580000162124634},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3313869833946228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33004891872406006}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:stars.library.ucf.edu:etd-4823","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/3823","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},{"id":"mag:148753030","doi":null,"is_oa":false,"landing_page_url":"https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=4823&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:stars.library.ucf.edu:etd-4823","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/3823","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1481829829","https://openalex.org/W1531832162","https://openalex.org/W1540826485","https://openalex.org/W1595834812","https://openalex.org/W1652237838","https://openalex.org/W1764972970","https://openalex.org/W1790197493","https://openalex.org/W1879457624","https://openalex.org/W1964574311","https://openalex.org/W1965877754","https://openalex.org/W1966081154","https://openalex.org/W1968378356","https://openalex.org/W1986866315","https://openalex.org/W1993198499","https://openalex.org/W2002180033","https://openalex.org/W2002353472","https://openalex.org/W2002873059","https://openalex.org/W2005875799","https://openalex.org/W2009607168","https://openalex.org/W2010099473","https://openalex.org/W2014944455","https://openalex.org/W2017662347","https://openalex.org/W2019328790","https://openalex.org/W2021094428","https://openalex.org/W2026205355","https://openalex.org/W2044343841","https://openalex.org/W2045140739","https://openalex.org/W2046238723","https://openalex.org/W2046478450","https://openalex.org/W2048397152","https://openalex.org/W2050636602","https://openalex.org/W2053993585","https://openalex.org/W2055172277","https://openalex.org/W2062392962","https://openalex.org/W2062561397","https://openalex.org/W2063699958","https://openalex.org/W2064891273","https://openalex.org/W2066079004","https://openalex.org/W2069288734","https://openalex.org/W2070777660","https://openalex.org/W2076237842","https://openalex.org/W2080818066","https://openalex.org/W2084345288","https://openalex.org/W2084652820","https://openalex.org/W2087251851","https://openalex.org/W2091898207","https://openalex.org/W2107538476","https://openalex.org/W2108244474","https://openalex.org/W2109098861","https://openalex.org/W2110784907","https://openalex.org/W2112620963","https://openalex.org/W2116265877","https://openalex.org/W2124085296","https://openalex.org/W2126950194","https://openalex.org/W2128211642","https://openalex.org/W2130989540","https://openalex.org/W2140538238","https://openalex.org/W2154745705","https://openalex.org/W2164642027","https://openalex.org/W2165984084","https://openalex.org/W2167342331","https://openalex.org/W2168272960","https://openalex.org/W2474861722","https://openalex.org/W4313308248"],"related_works":["https://openalex.org/W2036429261","https://openalex.org/W2080026207","https://openalex.org/W2005875799","https://openalex.org/W2179558859","https://openalex.org/W2482254420","https://openalex.org/W4237454736","https://openalex.org/W2063834584","https://openalex.org/W7096466223","https://openalex.org/W2150813685","https://openalex.org/W2121141076"],"abstract_inverted_index":{"Neuroprogenitor":[0],"cells":[1,13,47,227,274,365,391],"are":[2,275],"an":[3],"important":[4],"resource":[5],"because":[6],"of":[7,24,37,54,80,97,105,144,167,192,199,225,318,323,396,399,426,473,483],"their":[8],"potential":[9],"to":[10,27,72,99,117,131,142,183,343,366,368,373,379],"replace":[11],"damaged":[12,283],"in":[14,64,181,222,246,306,383,454,477],"the":[15,33,129,218,259,278,316,346,449,474],"brain":[16,279],"caused":[17,161,416],"by":[18,418],"trauma":[19],"and":[20,35,59,159,195,213,335,437,440,481],"disease.":[21],"It":[22,231],"is":[23,87,91,232,300],"great":[25],"importance":[26],"better":[28],"understand":[29],"which":[30,458],"factors":[31,127,290],"influence":[32],"differentiation":[34,79,143,224,480],"migration":[36,317,398,413,482],"these":[38,287],"cells.":[39,82,147,294,321,402,486],"Previously":[40],"it":[41],"has":[42,221,263,453],"been":[43],"reported":[44],"that":[45,90,124,150,234,261,271,286,291,304,312,389,410],"neuroprogenitor":[46,81,146,273,320,401,485],"undergoing":[48],"apoptotic":[49,126],"stress":[50],"have":[51,122,128,269],"increased":[52,60,153,235,307,419,424],"levels":[53],"Amyloid":[55],"precursor":[56],"protein":[57,111,157,330,359,443],"(APP)":[58],"APP":[61,67,178,188,220,236,393,411,423,452],"expression":[62,104,114,140,152,158,179,191,237,376,425],"results":[63,171,305],"glial":[65,78,154,168,223,479],"differentiation.":[66,134,169],"activity":[68,189],"was":[69,341,361,377,414],"also":[70,160],"shown":[71,123,270,378],"be":[73],"required":[74,362],"for":[75,363],"staurosporine":[76],"induced":[77,110,348,412],"Monocyte":[83],"chemoattractant":[84],"protein-1":[85],"(MCP-1)":[86],"a":[88,243,301,381,404,470],"chemokine":[89,101,308,456],"expressed":[92],"during":[93],"inflammatory.":[94],"The":[95],"binding":[96],"MCP-1":[98,109,175,194,212,247,262,313,347,375,405,420],"its":[100],"receptor":[102],"induces":[103,315],"novel":[106],"transcription":[107],"factor":[108],"(MCPIP).":[112],"MCPIP":[113,139,151],"subsequently":[115],"leads":[116,141],"cell":[118,266,385,461],"death.":[119],"Previous":[120],"studies":[121],"pro":[125],"ability":[130,372],"induce":[132],"neural":[133],"Therefore,":[135],"we":[136,186,408],"investigated":[137,258],"if":[138],"NT2":[145,226,265,319,364,384,390,484],"Results":[148],"showed":[149,388],"fibrillary":[155],"acid":[156],"distinct":[162],"morphological":[163],"changes,":[164],"both":[165,193,478],"indicative":[166],"Similar":[170],"were":[172,394],"observed":[173],"with":[174,333,469],"treatment.":[176],"Interestingly,":[177,370,422],"decreased":[180],"response":[182,303],"MCPIP.":[184,196,214],"Instead,":[185],"found":[187],"regulates":[190],"Furthermore,":[197],"inhibition":[198],"either":[200],"p38":[201,356],"MAPK":[202],"or":[203,329,355],"JAK":[204],"signaling":[205],"pathways":[206],"significantly":[207,314],"reduced":[208],"APP's":[209,371],"effect":[210,260],"on":[211,264],"These":[215],"data":[216],"demonstrate":[217,311],"role":[219,245,382,451],"through":[228],"MCP-1/MCPIP":[229],"signaling.":[230],"possible":[233],"after":[238,296],"CNS":[239],"injury":[240,298],"could":[241],"play":[242,380],"ii":[244],"production,":[248,457],"possibly":[249],"promoting":[250],"astrocyte":[251],"activation":[252],"at":[253],"injured":[254],"site.":[255],"We":[256,310,387],"next":[257],"migration.":[267,349,386,462],"Studies":[268],"when":[272],"transplanted":[276],"into":[277],"they":[280],"migrate":[281],"towards":[282],"areas,":[284],"suggesting":[285],"areas":[288],"express":[289],"recruit":[292],"migrating":[293],"Generally,":[295],"neuronal":[297],"there":[299],"neuroinflammatory":[302],"production.":[309,421],"Activation":[322],"intracellular":[324],"cyclic":[325],"adenosine":[326],"monophosphate":[327],"(cAMP)":[328],"kinase":[331,354,360],"C":[332],"forskolin":[334],"phorbol":[336],"12-myristate":[337],"13-acetate":[338],"(PMA),":[339],"respectively,":[340],"able":[342],"completely":[344],"abolish":[345],"Contrarily,":[350],"neither":[351],"extracellular":[352],"signal-regulated":[353],"mitogen":[357],"activated":[358],"respond":[367],"MCP-1.":[369],"activate":[374],"expressing":[392],"capable":[395],"inducing":[397],"other":[400],"Utilizing":[403],"neutralizing":[406],"antibody":[407],"discovered":[409],"not":[415],"solely":[417],"several":[427],"C-C":[428],"chemokines:":[429],"MCP-1,":[430],"Regulated":[431],"upon":[432],"Activation,":[433],"Normal":[434],"T-cell":[435],"Expressed,":[436],"Secreted":[438],"(RANTES),":[439],"macrophage":[441],"inflammatory":[442],"alpha":[444],"(MIP-1":[445],"alpha).":[446],"This":[447],"demonstrates":[448],"unique":[450],"regulating":[455],"directly":[459],"affects":[460],"Taken":[463],"together,":[464],"this":[465],"study":[466],"provides":[467],"us":[468],"greater":[471],"understanding":[472],"mechanisms":[475],"involved":[476]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}