{"id":"https://openalex.org/W1487220185","doi":"https://doi.org/10.21236/ada598375","title":"Overcoming the Mechanism of Radioresistance in Neuroblastoma","display_name":"Overcoming the Mechanism of Radioresistance in Neuroblastoma","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1487220185","doi":"https://doi.org/10.21236/ada598375","mag":"1487220185"},"language":"en","primary_location":{"id":"doi:10.21236/ada598375","doi":"https://doi.org/10.21236/ada598375","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada598375","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074559844","display_name":"Brian Marples","orcid":"https://orcid.org/0000-0002-8684-4372","observed_orcids":["https://orcid.org/0000-0002-8684-4372"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brian Marples","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074559844"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.36079999804496765,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.36079999804496765,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.3118000030517578,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.9789999723434448},{"id":"https://openalex.org/keywords/low-dose-fractionated-radiotherapy","display_name":"low-dose fractionated radiotherapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7099999785423279},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.8460000157356262},{"id":"https://openalex.org/keywords/normal-tissue-sparing","display_name":"normal tissue sparing","score":0.6549999713897705},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.9291605949401855},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7278003692626953},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.41280660033226013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27707451581954956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09276750683784485},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0718311071395874},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.06431585550308228},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada598375","doi":"https://doi.org/10.21236/ada598375","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada598375","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1794577973","https://openalex.org/W1915190111","https://openalex.org/W2011694734","https://openalex.org/W2014785934","https://openalex.org/W2021784693","https://openalex.org/W2021810262","https://openalex.org/W2031770601","https://openalex.org/W2056802151","https://openalex.org/W2072153851","https://openalex.org/W2095120446","https://openalex.org/W2096609221","https://openalex.org/W2124252075","https://openalex.org/W2140083846","https://openalex.org/W2142736035","https://openalex.org/W2154080839","https://openalex.org/W2321231819"],"related_works":["https://openalex.org/W1997986379","https://openalex.org/W2600252755","https://openalex.org/W2089852930","https://openalex.org/W2954410472","https://openalex.org/W2037678428","https://openalex.org/W2809025698","https://openalex.org/W2016360039","https://openalex.org/W2040351716","https://openalex.org/W2745450362","https://openalex.org/W2032358963"],"abstract_inverted_index":{"Abstract":[0],":":[1],"Patient":[2],"survival":[3,142],"for":[4,302],"highly":[5],"aggressive":[6,16],"advanced-stage":[7],"neuroblastoma":[8,211],"remains":[9],"poor":[10],"despite":[11],"a":[12,88,99,146,155,175,219,246],"multidisciplinary":[13],"approach":[14],"involving":[15],"surgery,":[17],"chemotherapy":[18],"and":[19,28,121,136,169,184,213,248,258,274,282,288],"adjuvant":[20,52],"radiotherapy":[21,42,59],"(RT).":[22],"The":[23,72],"large":[24],"RT":[25,81],"treatment":[26,64],"volume,":[27],"concerns":[29],"about":[30],"the":[31,38,49,95,109,198,214],"proximity":[32],"of":[33,41,51,79,111,149,203,222],"radiosensitive":[34],"normal":[35,69],"structures,":[36],"restricts":[37],"tumoricidal":[39],"dose":[40,128,148,161,221],"that":[43,101,145],"can":[44],"be":[45],"delivered":[46,58,157,165],"which":[47],"limits":[48],"effectiveness":[50],"RT.":[53],"To":[54],"address":[55],"this,":[56],"we":[57],"using":[60,87,174,251],"an":[61],"entirely":[62],"novel":[63],"schedule":[65],"designed":[66],"to":[67,75,93,107,119,154,257],"minimize":[68],"tissue":[70],"damage.":[71],"concept":[73],"was":[74,151,164,239],"deliver":[76],"10":[77,83,227],"pulses":[78],"low-dose":[80],"(PRT,":[82],"x":[84],"0.2":[85],"Gy)":[86],"3":[89],"minute":[90],"inter-pulse":[91],"interval":[92],"introduce":[94],"RT-induced":[96],"damage":[97,124,134],"at":[98,126,166,171,200,278,293],"level":[100,129],"spares":[102],"tumor":[103,117],"vasculature":[104],"in":[105,197,269],"order":[106],"prevent":[108],"development":[110],"treatment-induced":[112],"hypoxia,":[113],"since":[114],"this":[115,127],"increases":[116],"resistance":[118],"radiation":[120,262],"chemotherapy.":[122],"Moreover,":[123],"produced":[125],"evades":[130],"ATM":[131],"dose-dependent":[132],"DNA":[133],"detection":[135],"repair":[137],"mechanisms.":[138],"In":[139],"vitro":[140],"clonogenic":[141],"experiments":[143],"demonstrated":[144],"single":[147],"PRT":[150,163,234,273,297],"not":[152],"inferior":[153],"continuously":[156],"standard":[158],"2":[159,259],"Gy":[160,224],"(SRT).":[162],"0.25":[167],"Gy/min":[168,173],"SRT":[170,275,303],"0.69":[172],"Faxitron":[176],"160":[177],"kVp":[178],"animal":[179],"X-irradiator":[180],"(0.5":[181],"mm":[182],"Cu":[183],"Al":[185],"filters;":[186],"HVL:":[187],"0.77":[188],"(mm":[189],"CU)).":[190],"Female":[191],"CB-17/SCID":[192],"mice":[193],"were":[194,276],"xenotransplanted":[195],"subcutaneously":[196],"flank":[199],"6-8":[201],"weeks":[202],"age":[204],"with":[205,218,299],"either":[206,233],"SK-N-SH,":[207],"SK-N-BE":[208,265],"or":[209,235],"MC-IXC":[210],"cells":[212],"subsequent":[215],"tumors":[216],"irradiated":[217],"total":[220],"20":[223],"given":[225],"over":[226],"consecutive":[228],"days":[229,260,280,284,295,301],"(2":[230],"Gy/day)":[231],"as":[232],"SRT.":[236],"Tumor":[237],"response":[238],"evaluated":[240],"by":[241,249],"physical":[242],"measurements":[243],"three":[244],"times":[245],"week":[247],"imaging":[250],"F18-FDG":[252],"PET/CT":[253],"1":[254],"day":[255],"prior":[256],"post":[261,286],"treatment.":[263],"For":[264],"tumors,":[266],"significant":[267],"differences":[268],"CT":[270],"volume":[271],"between":[272],"evident":[277],"5":[279],"(p=0.008)":[281],"21":[283],"(p=0.014)":[285],"treatment,":[287],"animals":[289],"reached":[290],"endpoint":[291],"criteria":[292],"56":[294],"after":[296],"compared":[298],"43":[300],"(p=0.012).":[304]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
