{"id":"https://openalex.org/W1486945682","doi":null,"title":"Medical therapy for benign prostatic hyperplasia--present and future impact.","display_name":"Medical therapy for benign prostatic hyperplasia--present and future impact.","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W1486945682","mag":"1486945682","pmid":"https://pubmed.ncbi.nlm.nih.gov/17295599"},"language":"en","primary_location":{"id":"pmid:17295599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17295599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109166400","display_name":"Muta M. Issa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muta M Issa","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA 30322, USA. issa@emory.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA 30322, USA. issa@emory.edu","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000972901","display_name":"Timothy S. Regan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy S Regan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3299,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.86919267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13 Suppl 1","issue":null,"first_page":"S4","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":1.0},{"id":"https://openalex.org/keywords/prostate-enlargement","display_name":"prostate enlargement","score":0.8220000267028809},{"id":"https://openalex.org/keywords/medical-therapy","display_name":"medical therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dutasteride","display_name":"dutasteride","score":0.8799999952316284},{"id":"https://openalex.org/keywords/finasteride","display_name":"finasteride","score":1.0},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.9449999928474426},{"id":"https://openalex.org/keywords/acute-urinary-retention","display_name":"acute urinary retention","score":0.9629999995231628},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/treatment-costs","display_name":"treatment costs","score":0.5109999775886536},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.6060000061988831},{"id":"https://openalex.org/keywords/economic-burden","display_name":"economic burden","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8725491166114807},{"id":"https://openalex.org/C2775874879","wikidata":"https://www.wikidata.org/wiki/Q424167","display_name":"Finasteride","level":4,"score":0.7583286762237549},{"id":"https://openalex.org/C2778878792","wikidata":"https://www.wikidata.org/wiki/Q424760","display_name":"Dutasteride","level":4,"score":0.6991944313049316},{"id":"https://openalex.org/C2780265253","wikidata":"https://www.wikidata.org/wiki/Q1416012","display_name":"Managed care","level":3,"score":0.5265044569969177},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.49215835332870483},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4874889850616455},{"id":"https://openalex.org/C100406419","wikidata":"https://www.wikidata.org/wiki/Q3543802","display_name":"Formulary","level":2,"score":0.46562761068344116},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.439447820186615},{"id":"https://openalex.org/C2779231881","wikidata":"https://www.wikidata.org/wiki/Q5977147","display_name":"Medical literature","level":2,"score":0.41469281911849976},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.2838224768638611},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.23161762952804565},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1885645091533661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1453060507774353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10056433081626892},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008329","descriptor_name":"Managed Care Programs","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011468","descriptor_name":"Prostatectomy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D011468","descriptor_name":"Prostatectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016055","descriptor_name":"Urinary Retention","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016055","descriptor_name":"Urinary Retention","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17295599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17295599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},{"id":"mag:1486945682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17295599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W118252468","https://openalex.org/W155634331","https://openalex.org/W1559506232","https://openalex.org/W1583264770","https://openalex.org/W1972848666","https://openalex.org/W1977899776","https://openalex.org/W1977948413","https://openalex.org/W1999798294","https://openalex.org/W2025055831","https://openalex.org/W2029265084","https://openalex.org/W2052970787","https://openalex.org/W2053761768","https://openalex.org/W2054957776","https://openalex.org/W2074432613","https://openalex.org/W2105669626","https://openalex.org/W2106455438","https://openalex.org/W2110588952","https://openalex.org/W2117494881","https://openalex.org/W2121759271","https://openalex.org/W2126104986","https://openalex.org/W2147450987","https://openalex.org/W2167083509","https://openalex.org/W2299367035","https://openalex.org/W2395577677","https://openalex.org/W2406121184","https://openalex.org/W2436431226","https://openalex.org/W2570577080","https://openalex.org/W2789938556","https://openalex.org/W2804551733"],"related_works":["https://openalex.org/W2409752089","https://openalex.org/W2184749154","https://openalex.org/W2524035794","https://openalex.org/W2066144433","https://openalex.org/W2067641122","https://openalex.org/W3162948765","https://openalex.org/W2163814631","https://openalex.org/W2285202500","https://openalex.org/W2793091868","https://openalex.org/W2783374353"],"abstract_inverted_index":{"The":[0,109,132,151],"purpose":[1],"of":[2,18,26,29,49,55,83,119,140,209],"this":[3,90,107],"manuscript":[4,96],"is":[5,75,177],"to":[6,22,78,100,124,179,196],"provide":[7],"clinicians,":[8],"health":[9],"plan":[10],"decision":[11,184],"makers,":[12],"and":[13,46,58,121,128,161,190,199,218],"policy":[14],"makers":[15,185],"with":[16,60,67,115,147,159],"highlights":[17],"key":[19,188],"findings":[20],"pertaining":[21],"our":[23],"current":[24],"understanding":[25],"the":[27,44,61,113,155,202],"condition":[28],"enlarged":[30],"prostate":[31],"(EP)":[32],"from":[33,169],"a":[34,40,53,68,80,116,170],"managed":[35,172,181],"care":[36,173,182],"perspective.":[37],"This":[38,73,95,175],"includes":[39],"brief":[41],"discussion":[42],"regarding":[43],"prevalence":[45],"economic":[47,191],"burden":[48],"EP,":[50,84],"followed":[51],"by":[52],"review":[54,82,87],"clinical":[56,189],"characteristics":[57],"pathophysiology,":[59],"final":[62],"section":[63],"on":[64,70,89],"treatment":[65],"approaches":[66],"focus":[69],"pharmacologic":[71],"options.":[72],"supplement":[74,176],"not":[76,206],"intended":[77,178],"be":[79],"comprehensive":[81],"because":[85],"many":[86],"articles":[88,166],"subject":[91],"are":[92],"available":[93],"elsewhere.":[94],"does,":[97],"however,":[98],"serve":[99],"introduce":[101],"3":[102,165],"additional":[103],"manuscripts":[104],"contained":[105],"within":[106],"supplement.":[108],"first":[110],"article":[111,134,153],"provides":[112],"readers":[114],"real-world":[117],"comparison":[118],"dutasteride":[120,148,160,198],"finasteride":[122,162],"relative":[123],"acute":[125],"urinary":[126],"retention":[127],"surgery":[129],"attenuation":[130],"rates.":[131],"second":[133],"investigates":[135],"differences":[136],"in":[137,145,186],"discontinuation":[138],"rates":[139],"alpha":[141],"blockers":[142],"when":[143],"used":[144],"combination":[146],"or":[149],"finasteride.":[150,200],"last":[152],"addresses":[154],"cost":[156],"implications":[157],"associated":[158],"therapy.":[163],"All":[164],"represent":[167],"data":[168,192],"naturalistic,":[171],"population.":[174],"assist":[180],"formulary":[183],"evaluating":[187],"which":[193],"could":[194],"help":[195],"differentiate":[197],"Although":[201],"information":[203],"presented":[204],"does":[205],"prove":[207],"superiority":[208],"either":[210],"product,":[211],"it":[212],"will":[213],"answer":[214],"some":[215,220],"important":[216,221],"questions":[217],"raise":[219],"issues":[222],"beyond":[223],"ingredient":[224],"cost.":[225]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}