{"id":"https://openalex.org/W1486604455","doi":"https://doi.org/10.1016/bs.mcb.2014.10.018","title":"Methods for monitoring lysosomal morphology","display_name":"Methods for monitoring lysosomal morphology","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1486604455","doi":"https://doi.org/10.1016/bs.mcb.2014.10.018","mag":"1486604455","pmid":"https://pubmed.ncbi.nlm.nih.gov/25665438"},"language":"en","primary_location":{"id":"doi:10.1016/bs.mcb.2014.10.018","doi":"https://doi.org/10.1016/bs.mcb.2014.10.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.mcb.2014.10.018","pdf_url":null,"source":{"id":"https://openalex.org/S177811526","display_name":"Methods in cell biology","issn_l":"0091-679X","issn":["0091-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Cell Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W657702106","display_name":"Lysosomes and Lysosomal Diseases"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012911477","display_name":"Bethan S. Kilpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bethan S. Kilpatrick","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014479377","display_name":"Emily R. Eden","orcid":"https://orcid.org/0000-0001-9352-5532","observed_orcids":["https://orcid.org/0000-0001-9352-5532"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily R. Eden","raw_affiliation_strings":["Department of Cell Biology, Institute of Ophthalmology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Institute of Ophthalmology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086992441","display_name":"Leanne N. Hockey","orcid":"https://orcid.org/0000-0001-5716-7643","observed_orcids":["https://orcid.org/0000-0001-5716-7643"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Leanne N. Hockey","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048265536","display_name":"Clare E. Futter","orcid":"https://orcid.org/0000-0001-5559-9389","observed_orcids":["https://orcid.org/0000-0001-5559-9389"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare E. Futter","raw_affiliation_strings":["Department of Cell Biology, Institute of Ophthalmology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Institute of Ophthalmology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086481218","display_name":"Sandip Patel","orcid":"https://orcid.org/0000-0001-7247-2013","observed_orcids":["https://orcid.org/0000-0001-7247-2013"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sandip Patel","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086481218"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":3.2075,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.90660793,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"126","issue":null,"first_page":"1","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.1785999983549118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lysosomal-morphology","display_name":"lysosomal morphology","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lysosomal-storage-disorders","display_name":"lysosomal storage disease","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.6430000066757202},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.875},{"id":"https://openalex.org/keywords/fluorescent-probes","display_name":"fluorescent probes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.8519999980926514},{"id":"https://openalex.org/keywords/electron-microscopy","display_name":"electron microscopy","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.9488831758499146},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.805742084980011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7875115871429443},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6781721115112305},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5840103030204773},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.471529096364975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20739462971687317},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.1830642819404602},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16430315375328064},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06913912296295166},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.06468519568443298}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016707","descriptor_name":"Tissue Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053140","descriptor_name":"Organelle Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/bs.mcb.2014.10.018","doi":"https://doi.org/10.1016/bs.mcb.2014.10.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.mcb.2014.10.018","pdf_url":null,"source":{"id":"https://openalex.org/S177811526","display_name":"Methods in cell biology","issn_l":"0091-679X","issn":["0091-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Cell Biology","raw_type":"book-chapter"},{"id":"pmid:25665438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25665438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1462644","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1462644/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"LYSOSOMES AND LYSOSOMAL DISEASES , 126 pp. 1-19. (2015)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1461006323","display_name":null,"funder_award_id":"K-1107","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"},{"id":"https://openalex.org/G2741465026","display_name":"The molecular basis for calcium release by NAADP","funder_award_id":"BB/G013721/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3138131554","display_name":"Formation and function of Membrane Contact Sites between the ER and the phagocytic pathway in the Retinal Pigment Epithelium.","funder_award_id":"MR/M010767/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3787271969","display_name":null,"funder_award_id":"H-1202","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"},{"id":"https://openalex.org/G4397111046","display_name":null,"funder_award_id":"K-1412","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"},{"id":"https://openalex.org/G505100935","display_name":null,"funder_award_id":"1676068","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8017273139","display_name":"A role for a novel animal endo-lysosomal Ca2+/H+ exchanger in Ca2+ signalling and chemotaxis.","funder_award_id":"BB/K000942/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1491957044","https://openalex.org/W1510849499","https://openalex.org/W1791904161","https://openalex.org/W1900339045","https://openalex.org/W1964549513","https://openalex.org/W1984579655","https://openalex.org/W1986104600","https://openalex.org/W1989779273","https://openalex.org/W1990387678","https://openalex.org/W1991150334","https://openalex.org/W1992189978","https://openalex.org/W1993401680","https://openalex.org/W1995863785","https://openalex.org/W2000678720","https://openalex.org/W2001591494","https://openalex.org/W2011912954","https://openalex.org/W2016894006","https://openalex.org/W2017593971","https://openalex.org/W2021069524","https://openalex.org/W2021492060","https://openalex.org/W2029870086","https://openalex.org/W2031790758","https://openalex.org/W2037307064","https://openalex.org/W2042195196","https://openalex.org/W2042710439","https://openalex.org/W2043822937","https://openalex.org/W2054462619","https://openalex.org/W2058616210","https://openalex.org/W2062562477","https://openalex.org/W2071631353","https://openalex.org/W2075729810","https://openalex.org/W2077499130","https://openalex.org/W2079133058","https://openalex.org/W2079823127","https://openalex.org/W2080768598","https://openalex.org/W2082543204","https://openalex.org/W2087265011","https://openalex.org/W2089033487","https://openalex.org/W2095220436","https://openalex.org/W2099434729","https://openalex.org/W2102696072","https://openalex.org/W2104757714","https://openalex.org/W2108175824","https://openalex.org/W2112045725","https://openalex.org/W2112329697","https://openalex.org/W2115596765","https://openalex.org/W2127063807","https://openalex.org/W2127088485","https://openalex.org/W2130361709","https://openalex.org/W2133253871","https://openalex.org/W2134893181","https://openalex.org/W2138786573","https://openalex.org/W2139369185","https://openalex.org/W2139948451","https://openalex.org/W2146949990","https://openalex.org/W2148351021","https://openalex.org/W2150832037","https://openalex.org/W2153188271","https://openalex.org/W2155239512","https://openalex.org/W2157869491","https://openalex.org/W2157963288","https://openalex.org/W2166434963","https://openalex.org/W2171205888","https://openalex.org/W4211044652"],"related_works":["https://openalex.org/W120261959","https://openalex.org/W2608718507","https://openalex.org/W614454894","https://openalex.org/W2035163107","https://openalex.org/W3109334843","https://openalex.org/W2908014474","https://openalex.org/W4221096222","https://openalex.org/W4392159860","https://openalex.org/W4412743536","https://openalex.org/W4211203586"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}