{"id":"https://openalex.org/W1486589502","doi":"https://doi.org/10.1113/jphysiol.2011.207548","title":"K Ca 3.1 channels facilitate K + secretion or Na + absorption depending on apical or basolateral P2Y receptor stimulation","display_name":"K Ca 3.1 channels facilitate K + secretion or Na + absorption depending on apical or basolateral P2Y receptor stimulation","publication_year":2011,"publication_date":"2011-05-23","ids":{"openalex":"https://openalex.org/W1486589502","doi":"https://doi.org/10.1113/jphysiol.2011.207548","mag":"1486589502","pmid":"https://pubmed.ncbi.nlm.nih.gov/21606112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3167112"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2011.207548","doi":"https://doi.org/10.1113/jphysiol.2011.207548","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2011.207548","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3167112/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056151779","display_name":"Melissa L. Palmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa L. Palmer","raw_affiliation_strings":["Biology Program, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA","Biology Program, College of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Program, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Biology Program, College of Biological Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019846578","display_name":"Elizabeth R. Peitzman","orcid":"https://orcid.org/0000-0002-6198-1020","observed_orcids":["https://orcid.org/0000-0002-6198-1020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth R. Peitzman","raw_affiliation_strings":["Departments of Animal Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Animal Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015999967","display_name":"Peter J. Maniak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Maniak","raw_affiliation_strings":["Departments of Animal Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Animal Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055605191","display_name":"Gary Charles Sieck","orcid":"https://orcid.org/0000-0003-3040-9424","observed_orcids":["https://orcid.org/0000-0003-3040-9424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary C. Sieck","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079580565","display_name":"Y. S. Prakash","orcid":"https://orcid.org/0000-0002-2968-224X","observed_orcids":["https://orcid.org/0000-0002-2968-224X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. S. Prakash","raw_affiliation_strings":["Departments of Anesthesiology and Physiology, Mayo Clinic, Rochester MN 55902, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Physiology, Mayo Clinic, Rochester MN 55902, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046267434","display_name":"Scott M. O\u2019Grady","orcid":"https://orcid.org/0000-0002-0474-5451","observed_orcids":["https://orcid.org/0000-0002-0474-5451"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M. O\u2019Grady","raw_affiliation_strings":["Departments of Animal Sciences","Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Animal Sciences","institution_ids":[]},{"raw_affiliation_string":"Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":1.8362,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81017987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"589","issue":"14","first_page":"3483","last_page":"3494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kca3-1","display_name":"KCa3.1","score":0.875},{"id":"https://openalex.org/keywords/p2y-receptors","display_name":"P2Y receptors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/p2y2-receptor","display_name":"P2Y2 receptor","score":0.9710000157356262},{"id":"https://openalex.org/keywords/purinergic-signaling","display_name":"purinergic signaling","score":0.7260000109672546},{"id":"https://openalex.org/keywords/potassium-secretion","display_name":"potassium secretion","score":0.75},{"id":"https://openalex.org/keywords/sodium-absorption","display_name":"sodium uptake","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/apical-membrane","display_name":"apical membrane","score":0.6150000095367432},{"id":"https://openalex.org/keywords/basolateral-membrane","display_name":"basolateral membrane","score":0.9789999723434448},{"id":"https://openalex.org/keywords/atpgammas","display_name":"ATP gamma S","score":0.6600000262260437},{"id":"https://openalex.org/keywords/uridine-triphosphate","display_name":"UTP","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.5839999914169312},{"id":"https://openalex.org/keywords/charybdotoxin","display_name":"charybdotoxin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/bapta-am","display_name":"BAPTA-AM","score":0.7580000162124634},{"id":"https://openalex.org/keywords/short-circuit-current","display_name":"short-circuit current","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.741623044013977},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5859683752059937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5797568559646606},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.5585487484931946},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5083152651786804},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46942856907844543},{"id":"https://openalex.org/C160225129","wikidata":"https://www.wikidata.org/wiki/Q6591687","display_name":"P2Y receptor","level":4,"score":0.4685700237751007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4590126574039459},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45058342814445496},{"id":"https://openalex.org/C2780419564","wikidata":"https://www.wikidata.org/wiki/Q5087002","display_name":"Charybdotoxin","level":3,"score":0.43829113245010376},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.4341888129711151},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.32921499013900757},{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.30781400203704834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27416515350341797},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2516133785247803},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1279056966304779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08173879981040955}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001030","descriptor_name":"Apamin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003022","descriptor_name":"Clotrimazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014544","descriptor_name":"Uridine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018999","descriptor_name":"Charybdotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D024681","descriptor_name":"Potassium Channels, Calcium-Activated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024681","descriptor_name":"Potassium Channels, Calcium-Activated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042361","descriptor_name":"Mammary Glands, Human","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042361","descriptor_name":"Mammary Glands, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058470","descriptor_name":"Receptors, Purinergic P2Y","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058470","descriptor_name":"Receptors, Purinergic P2Y","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058913","descriptor_name":"Purinergic Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.2011.207548","doi":"https://doi.org/10.1113/jphysiol.2011.207548","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2011.207548","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:21606112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21606112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3167112","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3167112/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3167112","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3167112/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2415697417","display_name":"CFTR regulation of airway epithelial cell migration","funder_award_id":"R21HL095811","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4182736304","display_name":null,"funder_award_id":"HL057460","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4529890805","display_name":"Calcium Regulation in Airway Smooth Muscle","funder_award_id":"R01HL074309","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6482850958","display_name":"Neurotrophins in the Lung","funder_award_id":"R01HL088029","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1816872","https://openalex.org/W1517485745","https://openalex.org/W1537329448","https://openalex.org/W1828150019","https://openalex.org/W1838696854","https://openalex.org/W1968455380","https://openalex.org/W1977663423","https://openalex.org/W1982771420","https://openalex.org/W1985661015","https://openalex.org/W1992489278","https://openalex.org/W1996992306","https://openalex.org/W2004049927","https://openalex.org/W2006839087","https://openalex.org/W2012405452","https://openalex.org/W2015112490","https://openalex.org/W2019316890","https://openalex.org/W2021958245","https://openalex.org/W2022127065","https://openalex.org/W2025888513","https://openalex.org/W2027210843","https://openalex.org/W2041266960","https://openalex.org/W2042724360","https://openalex.org/W2043762161","https://openalex.org/W2043893055","https://openalex.org/W2054967698","https://openalex.org/W2062454434","https://openalex.org/W2062793852","https://openalex.org/W2072118904","https://openalex.org/W2084916914","https://openalex.org/W2085436465","https://openalex.org/W2099389899","https://openalex.org/W2101691965","https://openalex.org/W2115906528","https://openalex.org/W2120245762","https://openalex.org/W2124269480","https://openalex.org/W2132941372","https://openalex.org/W2140772290","https://openalex.org/W2143670888","https://openalex.org/W2143805972","https://openalex.org/W2145346414","https://openalex.org/W2145382542","https://openalex.org/W2147771265","https://openalex.org/W2154238429","https://openalex.org/W2155532321","https://openalex.org/W2155867546","https://openalex.org/W2159089777","https://openalex.org/W2165927258","https://openalex.org/W2167684992","https://openalex.org/W2309473416","https://openalex.org/W2337505351"],"related_works":["https://openalex.org/W3173823271","https://openalex.org/W3176184854","https://openalex.org/W2784943658","https://openalex.org/W3177280001","https://openalex.org/W1995480785","https://openalex.org/W2149331248","https://openalex.org/W2157901841","https://openalex.org/W2099389899","https://openalex.org/W2061397578","https://openalex.org/W2092058593"],"abstract_inverted_index":{"Human":[0],"mammary":[1,224],"epithelial":[2],"(HME)":[3],"cells":[4],"express":[5],"several":[6],"P2Y":[7,50,112],"receptor":[8,51,113],"subtypes":[9],"located":[10],"in":[11,25,34,130,183],"both":[12],"apical":[13,44,111,134,185,202],"and":[14,57,89,98,103,126,152],"basolateral":[15,49,54,204],"membranes.":[16],"Apical":[17,78],"UTP":[18,199],"or":[19,198,203],"ATP-\u03b3-S":[20,157],"stimulation":[21,52],"of":[22,42,73,92,110,118,123,133,147,156,169,179,187,196,220],"monolayers":[23],"mounted":[24],"Ussing":[26],"chambers":[27],"evoked":[28],"a":[29,127],"rapid,":[30],"but":[31],"transient":[32],"decrease":[33,86],"short":[35],"circuit":[36],"current":[37],"(I(sc)),":[38],"consistent":[39],"with":[40,80,96],"activation":[41,75],"an":[43],"K+":[45,55,173],"conductance.":[46],"In":[47,100,139],"contrast,":[48,101],"activated":[53],"channels":[56,181],"increased":[58],"transepithelial":[59],"Na+":[60],"absorption.":[61],"Chelating":[62],"intracellular":[63],"Ca2+":[64],"using":[65],"the":[66,71,84,108,116,131,145,154,167,177,184,201,217,223],"membrane-permeable":[67],"compound":[68],"BAPTA-AM,":[69],"abolished":[70],"effects":[72,109,132,155,168,209],"purinoceptor":[74,135,170],"on":[76,137,172,210],"I(sc).":[77,138],"pretreatment":[79],"charybdotoxin":[81],"also":[82,192],"blocked":[83,153],"I(sc)":[85],"by":[87,150,158,175],">90%":[88],"similar":[90,128],"magnitudes":[91],"inhibition":[93,122],"were":[94],"observed":[95],"clotrimazole":[97],"TRAM-34.":[99],"iberiotoxin":[102],"apamin":[104],"did":[105],"not":[106],"block":[107],"stimulation.":[114],"Silencing":[115],"expression":[117,125],"K(Ca)3.1":[119,180],"produced":[120],"\u223c70%":[121],"mRNA":[124,149],"reduction":[129],"agonists":[136,171],"addition,":[140],"silencing":[141],"P2Y2":[142,148,164],"receptors":[143,165],"reduced":[144],"level":[146],"75%":[151],"65%.":[159],"These":[160],"results":[161,191],"suggest":[162],"that":[163,194,213],"mediate":[166],"secretion":[174],"regulating":[176],"activity":[178],"expressed":[182],"membrane":[186,205],"HME":[188],"cells.":[189],"The":[190],"indicate":[193],"release":[195],"ATP":[197],"across":[200],"elicits":[206],"qualitatively":[207],"different":[208],"ion":[211],"transport":[212],"may":[214],"ultimately":[215],"determine":[216],"[Na+]/[K+]":[218],"composition":[219],"fluid":[221],"within":[222],"ductal":[225],"network.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}