{"id":"https://openalex.org/W1486533390","doi":null,"title":"Interplay of virulence factors in complement resistance of Streptococcus pneumoniae","display_name":"Interplay of virulence factors in complement resistance of Streptococcus pneumoniae","publication_year":2011,"publication_date":"2011-05-06","ids":{"openalex":"https://openalex.org/W1486533390","mag":"1486533390"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/26119","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/26119","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/26119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020028910","display_name":"Merit M. Melin","orcid":"https://orcid.org/0000-0001-9375-4327","observed_orcids":["https://orcid.org/0000-0001-9375-4327"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Merit Melin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9375-4327","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020028910"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/complement-resistance","display_name":"complement resistance","score":0.8669999837875366},{"id":"https://openalex.org/keywords/complement-evasion","display_name":"complement evasion","score":0.7200000286102295},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/capsular-serotypes","display_name":"capsular serotypes","score":0.75},{"id":"https://openalex.org/keywords/capsule-polysaccharide","display_name":"polysaccharide capsule","score":0.9580000042915344},{"id":"https://openalex.org/keywords/opsonophagocytosis","display_name":"opsonophagocytosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/invasive-pneumococcal-disease","display_name":"invasive pneumococcal disease","score":0.722000002861023},{"id":"https://openalex.org/keywords/otitis-media","display_name":"otitis media","score":0.7559999823570251},{"id":"https://openalex.org/keywords/conjugate-vaccines","display_name":"conjugate vaccines","score":0.6460000276565552},{"id":"https://openalex.org/keywords/pneumococcal-serotyping","display_name":"pneumococcal serotyping","score":0.5289999842643738},{"id":"https://openalex.org/keywords/nasopharyngeal-carriage","display_name":"nasopharyngeal carriage","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.7802748680114746},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6937745213508606},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5939441919326782},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.4894782304763794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3529084026813507},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.115357905626297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1030246913433075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09515586495399475},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/26119","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/26119","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"pmh:oai:www.julkari.fi:10024/79994","doi":null,"is_oa":false,"landing_page_url":"http://www.julkari.fi/handle/10024/79994","pdf_url":null,"source":{"id":"https://openalex.org/S4306402058","display_name":"STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:1486533390","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/26119/1/interpla.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/26119","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/26119","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":385,"referenced_works":["https://openalex.org/W65113864","https://openalex.org/W173701420","https://openalex.org/W204218960","https://openalex.org/W1253835855","https://openalex.org/W1485264912","https://openalex.org/W1487925140","https://openalex.org/W1493339267","https://openalex.org/W1512543381","https://openalex.org/W1534337168","https://openalex.org/W1547190545","https://openalex.org/W1549694950","https://openalex.org/W1550704138","https://openalex.org/W1569782548","https://openalex.org/W1608014870","https://openalex.org/W1754166121","https://openalex.org/W1770149185","https://openalex.org/W1819705517","https://openalex.org/W1825557671","https://openalex.org/W1827417957","https://openalex.org/W1831821781","https://openalex.org/W1853422791","https://openalex.org/W1895102180","https://openalex.org/W1915845607","https://openalex.org/W1918510262","https://openalex.org/W1919385003","https://openalex.org/W1919786812","https://openalex.org/W1920906833","https://openalex.org/W1925180522","https://openalex.org/W1948307823","https://openalex.org/W1963596215","https://openalex.org/W1963858490","https://openalex.org/W1964139041","https://openalex.org/W1965859195","https://openalex.org/W1965997603","https://openalex.org/W1966120246","https://openalex.org/W1966299416","https://openalex.org/W1969350485","https://openalex.org/W1969548538","https://openalex.org/W1970450966","https://openalex.org/W1970692320","https://openalex.org/W1973815343","https://openalex.org/W1974357395","https://openalex.org/W1975277416","https://openalex.org/W1977398628","https://openalex.org/W1978465166","https://openalex.org/W1979917671","https://openalex.org/W1980219722","https://openalex.org/W1984874957","https://openalex.org/W1985020513","https://openalex.org/W1987875815","https://openalex.org/W1988038456","https://openalex.org/W1991373559","https://openalex.org/W1992601565","https://openalex.org/W1992692406","https://openalex.org/W1992975364","https://openalex.org/W1993100997","https://openalex.org/W1993124167","https://openalex.org/W1996539884","https://openalex.org/W1997168956","https://openalex.org/W1997203833","https://openalex.org/W1997248268","https://openalex.org/W1999932665","https://openalex.org/W2000615700","https://openalex.org/W2000666508","https://openalex.org/W2001021771","https://openalex.org/W2003403523","https://openalex.org/W2005730984","https://openalex.org/W2005741947","https://openalex.org/W2006044459","https://openalex.org/W2009862707","https://openalex.org/W2010717419","https://openalex.org/W2011696576","https://openalex.org/W2011706807","https://openalex.org/W2011750902","https://openalex.org/W2014520088","https://openalex.org/W2016524069","https://openalex.org/W2016758839","https://openalex.org/W2017368974","https://openalex.org/W2017479299","https://openalex.org/W2018063325","https://openalex.org/W2018556007","https://openalex.org/W2019221278","https://openalex.org/W2020256975","https://openalex.org/W2022603159","https://openalex.org/W2023116174","https://openalex.org/W2023690749","https://openalex.org/W2024682921","https://openalex.org/W2024833095","https://openalex.org/W2024886564","https://openalex.org/W2026479147","https://openalex.org/W2027818737","https://openalex.org/W2027951805","https://openalex.org/W2028299446","https://openalex.org/W2028552317","https://openalex.org/W2029482690","https://openalex.org/W2030236537","https://openalex.org/W2030330011","https://openalex.org/W2030520271","https://openalex.org/W2031895664","https://openalex.org/W2032474015","https://openalex.org/W2033464521","https://openalex.org/W2033867278","https://openalex.org/W2033992962","https://openalex.org/W2035070067","https://openalex.org/W2035407157","https://openalex.org/W2035975411","https://openalex.org/W2036814749","https://openalex.org/W2037450210","https://openalex.org/W2037634686","https://openalex.org/W2038441646","https://openalex.org/W2038701927","https://openalex.org/W2039795463","https://openalex.org/W2039902501","https://openalex.org/W2040017219","https://openalex.org/W2040483457","https://openalex.org/W2040513987","https://openalex.org/W2041691901","https://openalex.org/W2042439640","https://openalex.org/W2042590335","https://openalex.org/W2043915983","https://openalex.org/W2044204097","https://openalex.org/W2044764627","https://openalex.org/W2045283400","https://openalex.org/W2045383897","https://openalex.org/W2045808776","https://openalex.org/W2047090489","https://openalex.org/W2047501687","https://openalex.org/W2048032624","https://openalex.org/W2048172864","https://openalex.org/W2048844545","https://openalex.org/W2048960863","https://openalex.org/W2050932617","https://openalex.org/W2052643656","https://openalex.org/W2052759282","https://openalex.org/W2053802108","https://openalex.org/W2054791867","https://openalex.org/W2055079545","https://openalex.org/W2055392678","https://openalex.org/W2055925653","https://openalex.org/W2055952697","https://openalex.org/W2057576654","https://openalex.org/W2057763292","https://openalex.org/W2059608310","https://openalex.org/W2061486920","https://openalex.org/W2063060952","https://openalex.org/W2063392571","https://openalex.org/W2064231049","https://openalex.org/W2064900873","https://openalex.org/W2065032957","https://openalex.org/W2066226017","https://openalex.org/W2066749638","https://openalex.org/W2066869721","https://openalex.org/W2067200826","https://openalex.org/W2068383131","https://openalex.org/W2070088956","https://openalex.org/W2070485926","https://openalex.org/W2070627443","https://openalex.org/W2070650369","https://openalex.org/W2071916306","https://openalex.org/W2072498492","https://openalex.org/W2073623607","https://openalex.org/W2074670609","https://openalex.org/W2075357156","https://openalex.org/W2076332584","https://openalex.org/W2076893605","https://openalex.org/W2078466641","https://openalex.org/W2079722419","https://openalex.org/W2082678852","https://openalex.org/W2083358517","https://openalex.org/W2083367830","https://openalex.org/W2084411853","https://openalex.org/W2084541598","https://openalex.org/W2084753274","https://openalex.org/W2084902307","https://openalex.org/W2084969272","https://openalex.org/W2086675285","https://openalex.org/W2087453197","https://openalex.org/W2088140700","https://openalex.org/W2092565111","https://openalex.org/W2092915795","https://openalex.org/W2093717213","https://openalex.org/W2094275695","https://openalex.org/W2094590459","https://openalex.org/W2094689350","https://openalex.org/W2095730944","https://openalex.org/W2095824224","https://openalex.org/W2097750123","https://openalex.org/W2097937783","https://openalex.org/W2098218091","https://openalex.org/W2098332275","https://openalex.org/W2098483219","https://openalex.org/W2099155952","https://openalex.org/W2101218683","https://openalex.org/W2102387303","https://openalex.org/W2102537411","https://openalex.org/W2103613627","https://openalex.org/W2103637444","https://openalex.org/W2103657277","https://openalex.org/W2104722369","https://openalex.org/W2105008621","https://openalex.org/W2105289911","https://openalex.org/W2105771350","https://openalex.org/W2106120253","https://openalex.org/W2106850668","https://openalex.org/W2106979097","https://openalex.org/W2107474742","https://openalex.org/W2107825552","https://openalex.org/W2108360478","https://openalex.org/W2108855502","https://openalex.org/W2108901020","https://openalex.org/W2108995361","https://openalex.org/W2109752546","https://openalex.org/W2110584975","https://openalex.org/W2110624979","https://openalex.org/W2110997613","https://openalex.org/W2111281901","https://openalex.org/W2111511329","https://openalex.org/W2112183224","https://openalex.org/W2112249032","https://openalex.org/W2113175768","https://openalex.org/W2113297977","https://openalex.org/W2113333577","https://openalex.org/W2113898784","https://openalex.org/W2114420534","https://openalex.org/W2114930069","https://openalex.org/W2115071132","https://openalex.org/W2115116421","https://openalex.org/W2115908628","https://openalex.org/W2116108334","https://openalex.org/W2116384912","https://openalex.org/W2116643151","https://openalex.org/W2116738903","https://openalex.org/W2116979669","https://openalex.org/W2117205808","https://openalex.org/W2117244330","https://openalex.org/W2117888940","https://openalex.org/W2118878242","https://openalex.org/W2119422239","https://openalex.org/W2119446930","https://openalex.org/W2119458127","https://openalex.org/W2119658374","https://openalex.org/W2121228279","https://openalex.org/W2121476707","https://openalex.org/W2121832499","https://openalex.org/W2121861720","https://openalex.org/W2122153462","https://openalex.org/W2122234707","https://openalex.org/W2122486062","https://openalex.org/W2122598469","https://openalex.org/W2122709658","https://openalex.org/W2123389447","https://openalex.org/W2123990722","https://openalex.org/W2124219105","https://openalex.org/W2125841166","https://openalex.org/W2126552441","https://openalex.org/W2127090093","https://openalex.org/W2127243759","https://openalex.org/W2128173146","https://openalex.org/W2128697979","https://openalex.org/W2128721558","https://openalex.org/W2129091558","https://openalex.org/W2129315523","https://openalex.org/W2129457514","https://openalex.org/W2129860420","https://openalex.org/W2130754971","https://openalex.org/W2131554590","https://openalex.org/W2131574907","https://openalex.org/W2131765138","https://openalex.org/W2132321844","https://openalex.org/W2132993876","https://openalex.org/W2133210278","https://openalex.org/W2133454819","https://openalex.org/W2133579523","https://openalex.org/W2134493315","https://openalex.org/W2134606926","https://openalex.org/W2134811962","https://openalex.org/W2134983332","https://openalex.org/W2135152765","https://openalex.org/W2135195475","https://openalex.org/W2135761651","https://openalex.org/W2136061245","https://openalex.org/W2138424202","https://openalex.org/W2138663192","https://openalex.org/W2139284625","https://openalex.org/W2140370976","https://openalex.org/W2141343862","https://openalex.org/W2141957658","https://openalex.org/W2141972011","https://openalex.org/W2142009418","https://openalex.org/W2142890591","https://openalex.org/W2142965789","https://openalex.org/W2143051636","https://openalex.org/W2143453588","https://openalex.org/W2143471415","https://openalex.org/W2143970440","https://openalex.org/W2144235181","https://openalex.org/W2144240057","https://openalex.org/W2144440398","https://openalex.org/W2145435157","https://openalex.org/W2145812534","https://openalex.org/W2146484568","https://openalex.org/W2146544984","https://openalex.org/W2147284381","https://openalex.org/W2147710174","https://openalex.org/W2147812850","https://openalex.org/W2148143691","https://openalex.org/W2148365260","https://openalex.org/W2148434257","https://openalex.org/W2148637247","https://openalex.org/W2149395493","https://openalex.org/W2149706167","https://openalex.org/W2150432788","https://openalex.org/W2151428889","https://openalex.org/W2151470509","https://openalex.org/W2151555881","https://openalex.org/W2152785534","https://openalex.org/W2152933863","https://openalex.org/W2153158764","https://openalex.org/W2153736430","https://openalex.org/W2153842985","https://openalex.org/W2154300732","https://openalex.org/W2154407429","https://openalex.org/W2154563381","https://openalex.org/W2155523471","https://openalex.org/W2155580358","https://openalex.org/W2155820386","https://openalex.org/W2155857963","https://openalex.org/W2156131016","https://openalex.org/W2156400940","https://openalex.org/W2156659808","https://openalex.org/W2156980684","https://openalex.org/W2157819951","https://openalex.org/W2159189010","https://openalex.org/W2159490575","https://openalex.org/W2159553344","https://openalex.org/W2159602930","https://openalex.org/W2159726435","https://openalex.org/W2160332563","https://openalex.org/W2160985858","https://openalex.org/W2161806706","https://openalex.org/W2161963638","https://openalex.org/W2162339585","https://openalex.org/W2162503698","https://openalex.org/W2163188120","https://openalex.org/W2164497540","https://openalex.org/W2165390003","https://openalex.org/W2165861950","https://openalex.org/W2166908548","https://openalex.org/W2166930051","https://openalex.org/W2167221249","https://openalex.org/W2167435540","https://openalex.org/W2167678554","https://openalex.org/W2167696510","https://openalex.org/W2167866530","https://openalex.org/W2167888974","https://openalex.org/W2168451285","https://openalex.org/W2168579739","https://openalex.org/W2168613507","https://openalex.org/W2168998399","https://openalex.org/W2169215399","https://openalex.org/W2169448952","https://openalex.org/W2169661568","https://openalex.org/W2170651898","https://openalex.org/W2170949939","https://openalex.org/W2171648069","https://openalex.org/W2173015905","https://openalex.org/W2175262016","https://openalex.org/W2179693296","https://openalex.org/W2188055647","https://openalex.org/W2223662840","https://openalex.org/W2264219727","https://openalex.org/W2276614885","https://openalex.org/W2313210700","https://openalex.org/W2314929726","https://openalex.org/W2315566070","https://openalex.org/W2325123292","https://openalex.org/W2327195152","https://openalex.org/W2327544599","https://openalex.org/W2328356008","https://openalex.org/W2329109548","https://openalex.org/W2334476193","https://openalex.org/W2339539882","https://openalex.org/W2342228817","https://openalex.org/W2585732487","https://openalex.org/W4244022288"],"related_works":["https://openalex.org/W7098996600","https://openalex.org/W96687160","https://openalex.org/W7098933032","https://openalex.org/W2116901800","https://openalex.org/W62070723","https://openalex.org/W7008881148","https://openalex.org/W1480401645","https://openalex.org/W2133210278","https://openalex.org/W4288080499","https://openalex.org/W2086127657"],"abstract_inverted_index":{"Streptococcus":[0],"pneumoniae":[1,41,78,151,249,440],"(pneumococcus)":[2],"is":[3,42,64,122,212,264,364,387],"a":[4,15,35,57,153,193,213,224,252,415,444,514],"normal":[5],"inhabitant":[6],"of":[7,18,26,38,47,56,70,90,104,113,133,165,215,254,259,287,311,361,370,399,406,414,429,438,452,460,472,477,500,544,553,586,592,620],"the":[8,24,27,30,43,54,65,82,91,111,120,126,131,147,280,285,312,319,327,351,367,371,396,411,427,430,450,457,461,478,483,491,501,524,538,550,569,574,584,637],"human":[9,31,171],"nasopharynx.":[10],"Symptoms":[11],"occur":[12],"in":[13,29,34,170,202,318,324,377,456,465,516,626],"only":[14,443],"small":[16],"proportion":[17],"those":[19],"who":[20,204],"become":[21],"carriers,":[22,180],"but":[23,162,181,519],"ubiquity":[25],"organism":[28],"population":[32],"results":[33,504,619],"large":[36],"burden":[37],"disease.":[39,186,297,333,403,588],"S.":[40,77,150,248,439],"leading":[44],"bacterial":[45,484,525,539],"cause":[46,184,296,402],"pneumonia,":[48],"sepsis,":[49],"and":[50,84,140,217,240,262,292,309,342,374,380,432,598],"meningitis":[51],"worldwide,":[52],"causing":[53,200,331],"death":[55],"million":[58],"children":[59],"each":[60],"year.":[61],"Middle-ear":[62],"infection":[63,341],"most":[66,127,328],"common":[67,329],"clinical":[68],"manifestation":[69],"mucosal":[71],"pneumococcal":[72,106,242,315,372,453,507],"infections.":[73],"In":[74,447],"invasive":[75,185,332,346,560,587,638],"disease,":[76],"gains":[79],"access":[80],"to":[81,86,98,124,146,256,266,268,289,295,365,392,401,410,474,488,532,556,565,579,594],"bloodstream":[83],"spreads":[85],"normally":[87],"sterile":[88],"parts":[89],"body.":[92],"The":[93,116,209,271,314,358,384,404,470,503,527,559,589,618],"progression":[94],"from":[95,138,178,339,345],"asymptomatic":[96],"colonization":[97],"disease":[99,201,347],"depends":[100,348,522],"on":[101,350,420,435,482,490,497,523],"factors":[102,409,455],"characteristic":[103],"specific":[105],"strains":[107],"as":[108,110,152,223,278,494,496],"well":[109,279,495],"status":[112],"host":[114],"defenses.":[115,208],"polysaccharide":[117],"capsule":[118,373,431],"surrounding":[119],"bacterium":[121,462],"considered":[123],"be":[125,603],"important":[128],"factor":[129],"affecting":[130],"virulence":[132,375,408,433,454],"pneumococci.":[134],"It":[135],"protects":[136],"pneumococci":[137,473],"phagocytosis":[139],"also":[141,344],"may":[142,282,417,512],"determine":[143],"its":[144,269,293,421],"affinity":[145],"respiratory":[148],"epithelium.":[149],"species":[154],"comprises":[155],"more":[156,536,563],"than":[157,537,568],"90":[158],"different":[159,397,468,590],"capsular":[160,272,352,492,528],"serotypes,":[161,571],"not":[163],"all":[164,283],"them":[166],"are":[167,175,189,576,616,631],"equally":[168],"prevalent":[169],"diseases.":[172],"Invasive":[173],"serotypes":[174,330,391,400,554,561,593],"rarely":[176],"isolated":[177],"healthy":[179],"relatively":[182],"often":[183],"Serotypes":[187],"that":[188,221,337,506,573,624],"carried":[190],"asymptomatically":[191],"for":[192,235,276,354,549,609,612,633],"long":[194],"time":[195],"behave":[196],"like":[197],"opportunistic":[198,570],"pathogens,":[199],"patients":[203],"have":[205,425],"impaired":[206],"immune":[207,581],"complement":[210,236,291,307,378,394,412,436,458,479,517,534,595],"system":[211],"collection":[214],"blood":[216],"cell":[218],"surface":[219,485],"proteins":[220,237,274,376,434,511],"act":[222],"major":[225],"primary":[226],"defense":[227],"against":[228,636],"invading":[229],"microbes.":[230],"Phagocytic":[231],"cells":[232,243],"with":[233,245,299],"receptors":[234],"can":[238],"engulf":[239],"destroy":[241],"opsonized":[244],"these":[246],"proteins.":[247],"has":[250],"evolved":[251],"number":[253],"ways":[255],"subvert":[257],"mechanisms":[258,582],"innate":[260],"immunity,":[261],"this":[263,362,448,621],"likely":[265],"contribute":[267],"pathogenicity.":[270],"serotype,":[273,353],"essential":[275],"virulence,":[277],"genotype,":[281],"influence":[284,533],"ability":[286,471],"pneumococcus":[288],"resist":[290,393,580],"potential":[294],"Immunization":[298],"conjugate":[300],"vaccines":[301],"produces":[302],"opsonic":[303],"antibodies,":[304],"which":[305],"enhance":[306],"deposition":[308,476,567],"clearance":[310],"bacteria.":[313,502],"vaccine":[316,613],"included":[317],"Finnish":[320],"national":[321],"immunization":[322],"program":[323],"2010":[325],"contains":[326],"Clinical":[334],"data":[335],"suggest":[336,505,623],"protection":[338,601,635],"middle-ear":[340],"possibly":[343],"largely":[349],"reasons":[355],"hitherto":[356],"unknown.":[357],"general":[359],"aim":[360],"thesis":[363,622],"assess":[366],"relative":[368],"roles":[369],"evasion":[379],"subsequent":[381],"opsonophagocytic":[382,551],"killing.":[383],"main":[385],"question":[386],"whether":[388],"differences":[389],"between":[390],"explain":[395],"abilities":[398],"importance":[405],"particular":[407],"resistance":[413,437,459,535],"strain":[416],"vary":[418],"depending":[419],"genotype.":[422,526,540],"Prior":[423],"studies":[424],"evaluated":[426],"effect":[428],"by":[441],"comparing":[442],"few":[445],"strains.":[446,469],"thesis,":[449],"role":[451,515],"was":[463,486,530,547],"studied":[464],"several":[466],"genotypically":[467],"inhibit":[475],"protein":[480],"C3":[481,557,566],"found":[487,531],"depend":[489],"serotype":[493,529],"other":[498],"features":[499],"histidine":[508],"triad":[509],"(Pht)":[510],"play":[513],"inhibition,":[518],"their":[520],"contribution":[521],"A":[541],"higher":[542,627],"concentration":[543],"anticapsular":[545],"antibodies":[546,625],"required":[548],"killing":[552],"resistant":[555,564],"deposition.":[558],"were":[562],"suggesting":[572],"former":[575],"better":[577],"adapted":[578],"controlling":[583],"development":[585],"susceptibilities":[591],"deposition,":[596],"opsonophagocytosis,":[597],"resultant":[599],"antibody-mediated":[600],"should":[602],"taken":[604],"into":[605],"account":[606],"when":[607],"guidelines":[608],"serological":[610],"correlates":[611],"efficacy":[614],"evaluations":[615],"made.":[617],"quantity":[628],"or":[629],"quality":[630],"needed":[632],"efficient":[634],"serotypes.":[639]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}