{"id":"https://openalex.org/W1486485340","doi":null,"title":"The effects of counting threshold and emulsion exposure duration on the percent-labeled mitosis curve and their implications for cell cycle analysis.","display_name":"The effects of counting threshold and emulsion exposure duration on the percent-labeled mitosis curve and their implications for cell cycle analysis.","publication_year":1973,"publication_date":"1973-11-01","ids":{"openalex":"https://openalex.org/W1486485340","mag":"1486485340","pmid":"https://pubmed.ncbi.nlm.nih.gov/4795901"},"language":"en","primary_location":{"id":"pmid:4795901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4795901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027859218","display_name":"Stanley E. Shackney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Shackney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021308382","display_name":"Sharon S. Ford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Ford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071835914","display_name":"Anja Wittig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Wittig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8719,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.93401262,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"11","first_page":"2726","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.13850000500679016,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tritiated-thymidine-labeling","display_name":"tritiated thymidine labeling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dna-synthesis-rate","display_name":"DNA synthesis rate","score":0.6449999809265137},{"id":"https://openalex.org/keywords/s-phase-duration","display_name":"S phase duration","score":0.972000002861023},{"id":"https://openalex.org/keywords/cell-cycle-analysis","display_name":"cell cycle analysis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/sarcoma-180","display_name":"sarcoma 180","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-cycle-kinetics","display_name":"cell cycle kinetics","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6797999143600464},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6776258945465088},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.6438002586364746},{"id":"https://openalex.org/C62538594","wikidata":"https://www.wikidata.org/wiki/Q54389","display_name":"Tritium","level":2,"score":0.5785077214241028},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.5524415969848633},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.5435346364974976},{"id":"https://openalex.org/C40555254","wikidata":"https://www.wikidata.org/wiki/Q355549","display_name":"Photographic emulsion","level":4,"score":0.48945701122283936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4440881907939911},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36971211433410645},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36723726987838745},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.3397091031074524},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33046847581863403},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32926785945892334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24018165469169617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19250184297561646},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.11740529537200928},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09257429838180542},{"id":"https://openalex.org/C2781074174","wikidata":"https://www.wikidata.org/wiki/Q29290","display_name":"Silver halide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4795901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4795901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1486485340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4795901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W328387259","https://openalex.org/W1571661642","https://openalex.org/W1580310411","https://openalex.org/W1660588146","https://openalex.org/W1968305122","https://openalex.org/W1973243290","https://openalex.org/W1981334803","https://openalex.org/W1991121120","https://openalex.org/W2031779553","https://openalex.org/W2049102681","https://openalex.org/W2071005050","https://openalex.org/W2091702992","https://openalex.org/W2107069537"],"related_works":["https://openalex.org/W2152137893","https://openalex.org/W2090459029","https://openalex.org/W2130817744","https://openalex.org/W2041612351","https://openalex.org/W2486267985","https://openalex.org/W1505267264","https://openalex.org/W2008374232","https://openalex.org/W172262254","https://openalex.org/W2003122076","https://openalex.org/W1992063569"],"abstract_inverted_index":{"Percent-labeled":[0],"mitosis":[1,31],"curves":[2],"were":[3,57],"obtained":[4],"at":[5,60,64],"different":[6],"counting":[7,39,48],"thresholds":[8,49,62],"and":[9,20,41,50,63,84,107],"emulsion":[10,43,52,66,76],"exposure":[11,44,53,67],"durations":[12,54,182],"in":[13,18,93,118,183],"Sarcoma":[14],"180":[15],"cells":[16,95,119],"grown":[17],"vitro":[19],"pulse":[21],"labeled":[22,58],"with":[23,120],"tritiated":[24],"thymidine.":[25],"The":[26,69],"shape":[27],"of":[28,86,104,134,137,144,154,157,164,187],"the":[29,82,100,102,141,152,167,184],"percent-labeled":[30],"curve":[32],"was":[33],"found":[34],"to":[35,75,114,171,177],"be":[36,73,172],"dependent":[37],"on":[38,42],"threshold":[40],"duration.":[45],"At":[46],"low":[47,135],"prolonged":[51],"more":[55,173],"mitoses":[56],"than":[59,175],"higher":[61],"shorter":[65],"times.":[68,124],"results":[70],"could":[71],"not":[72,90],"attributed":[74],"background":[77],"noise.\n\nThe":[78],"data":[79],"suggest":[80],"that":[81,129,151],"onset":[83],"termination":[85],"DNA":[87,105],"synthesis":[88,106],"do":[89],"occur":[91],"abruptly":[92],"individual":[94],"as":[96,161],"they":[97],"progress":[98],"through":[99],"cycle;":[101],"rate":[103],"corresponding":[108],"nuclear":[109,138],"tritium":[110,139],"uptake":[111],"rise":[112],"gradually":[113],"a":[115,162],"maximum,":[116],"especially":[117],"long":[121],"cell":[122,179,189],"cycle":[123,168,180],"When":[125],"conditions":[126],"are":[127],"such":[128],"there":[130],"is":[131,147,149],"increased":[132],"detection":[133],"levels":[136],"uptake,":[140],"apparent":[142],"duration":[143],"S":[145],"phase":[146,181],"increased.\n\nIt":[148],"suggested":[150],"identification":[153],"distinctive":[155],"patterns":[156],"relative":[158],"labeling":[159],"intensity":[160],"function":[163],"age":[165],"within":[166],"may":[169],"prove":[170],"useful":[174],"attempts":[176],"measure":[178],"kinetic":[185],"characterization":[186],"growing":[188],"populations.":[190]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
