{"id":"https://openalex.org/W1486206751","doi":null,"title":"El virus de la gripe aviar: nuevos aspectos relativos a su patogenicidad y a estrategias para combatirlo","display_name":"El virus de la gripe aviar: nuevos aspectos relativos a su patogenicidad y a estrategias para combatirlo","publication_year":2009,"publication_date":"2009-06-21","ids":{"openalex":"https://openalex.org/W1486206751","mag":"1486206751"},"language":"es","primary_location":{"id":"mag:1486206751","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/articulo?codigo=3137203","pdf_url":null,"source":{"id":"https://openalex.org/S128770802","display_name":"Anales de la Real Academia Nacional de Farmacia","issn_l":"1697-4271","issn":["1697-4271","1697-428X","2174-8756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","poland-20"],"host_organization":"https://openalex.org/P4310322362","host_organization_name":"Royal Academy of Pharmacy","host_organization_lineage":["https://openalex.org/P4310322362"],"host_organization_lineage_names":["Royal Academy of Pharmacy"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Anales de la Real Academia Nacional de Farmacia","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035073518","display_name":"Jos\u00e9 Antonio Cabezas Fern\u00e1ndez del Campo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Antonio Cabezas Fern\u00e1ndez del Campo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035073518"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1822,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59711508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"2","first_page":"233","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/avian-influenza-virus","display_name":"avian influenza virus","score":0.8659999966621399},{"id":"https://openalex.org/keywords/1918-influenza-pandemic","display_name":"1918 influenza pandemic","score":0.8659999966621399},{"id":"https://openalex.org/keywords/h5n1-subtype","display_name":"H5N1 subtype","score":0.8980000019073486},{"id":"https://openalex.org/keywords/innate-immune-dysregulation","display_name":"innate immune dysregulation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8479999899864197},{"id":"https://openalex.org/keywords/reverse-genetics","display_name":"reverse genetics","score":0.6840000152587891},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.6039999723434448},{"id":"https://openalex.org/keywords/neuraminidase-inhibitors","display_name":"neuraminidase inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/oseltamivir","display_name":"oseltamivir","score":0.9980000257492065},{"id":"https://openalex.org/keywords/zanamivir","display_name":"zanamivir","score":1.0},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.45899999141693115},{"id":"https://openalex.org/keywords/pandemic-preparedness","display_name":"pandemic preparedness","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.773971676826477},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7171753644943237},{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.635754406452179},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5651227235794067},{"id":"https://openalex.org/C2781442963","wikidata":"https://www.wikidata.org/wiki/Q146075","display_name":"Zanamivir","level":5,"score":0.5439713597297668},{"id":"https://openalex.org/C64502627","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogenicity","level":2,"score":0.5330917239189148},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5310049057006836},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.528455913066864},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.49868249893188477},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4948226809501648},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.480308473110199},{"id":"https://openalex.org/C2780374985","wikidata":"https://www.wikidata.org/wiki/Q211509","display_name":"Oseltamivir","level":5,"score":0.4309753179550171},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38374394178390503},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1748688519001007},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1572217345237732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14483791589736938},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13551270961761475},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.10943916440010071},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1486206751","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/articulo?codigo=3137203","pdf_url":null,"source":{"id":"https://openalex.org/S128770802","display_name":"Anales de la Real Academia Nacional de Farmacia","issn_l":"1697-4271","issn":["1697-4271","1697-428X","2174-8756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","poland-20"],"host_organization":"https://openalex.org/P4310322362","host_organization_name":"Royal Academy of Pharmacy","host_organization_lineage":["https://openalex.org/P4310322362"],"host_organization_lineage_names":["Royal Academy of Pharmacy"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Anales de la Real Academia Nacional de Farmacia","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W179481115","https://openalex.org/W1481856315","https://openalex.org/W1535375295","https://openalex.org/W1561549603","https://openalex.org/W1963547303","https://openalex.org/W1980318325","https://openalex.org/W1988311275","https://openalex.org/W1988457839","https://openalex.org/W1993808037","https://openalex.org/W1996311210","https://openalex.org/W2033843609","https://openalex.org/W2039027344","https://openalex.org/W2044600321","https://openalex.org/W2052374402","https://openalex.org/W2052798257","https://openalex.org/W2073234751","https://openalex.org/W2074899179","https://openalex.org/W2075768517","https://openalex.org/W2086727917","https://openalex.org/W2090634289","https://openalex.org/W2091080506","https://openalex.org/W2096091144","https://openalex.org/W2103093438","https://openalex.org/W2104201091","https://openalex.org/W2106599854","https://openalex.org/W2110590479","https://openalex.org/W2113038532","https://openalex.org/W2115612309","https://openalex.org/W2122399224","https://openalex.org/W2130251737","https://openalex.org/W2130658702","https://openalex.org/W2141816893","https://openalex.org/W2149533101","https://openalex.org/W2154634584","https://openalex.org/W2166582607","https://openalex.org/W2169261357","https://openalex.org/W2169702034","https://openalex.org/W2412141909"],"related_works":["https://openalex.org/W2012929392","https://openalex.org/W4236168236","https://openalex.org/W2030918082","https://openalex.org/W2037709417","https://openalex.org/W139239104","https://openalex.org/W2089487384","https://openalex.org/W2086214991","https://openalex.org/W2103561226","https://openalex.org/W4249310009","https://openalex.org/W2381338154"],"abstract_inverted_index":{"Since":[0],"Taubenberger\u00b4s":[1],"team":[2],"recreated":[3],"each":[4],"of":[5,8,16,29,44,54,61,75,88,128,131,146,157,166,177],"the":[6,13,19,26,30,45,52,58,82,97,126,132,147,154,158,163,170],"genes":[7],"influenza":[9,77],"virus":[10],"that":[11,35,74,124],"caused":[12,95,161],"terrible":[14],"pandemic":[15,92],"1918-19":[17,76],"using":[18],"technique":[20],"called":[21],"reverse":[22],"genetics":[23],"and":[24,109,117],"checked":[25],"infectious":[27],"capacity":[28],"newborn":[31],"virus,":[32],"it":[33,139],"seems":[34],"its":[36],"high":[37],"pathogenicity":[38,72],"may":[39],"be":[40,141],"due":[41],"to":[42,80,143,168],"disregulation":[43,164],"innate":[46],"immune":[47,148],"mechanisms":[48,165],"normally":[49],"performed":[50],"by":[51,96,105,162],"cytokines":[53],"host":[55],"cell.":[56],"Furthermore,":[57],"H5N1":[59,98],"subtype":[60,99],"avian":[62],"influenza,":[63],"which":[64],"also":[65],"causes":[66],"a":[67],"similar":[68],"dysfunction,":[69],"has":[70,135],"higher":[71],"than":[73],"virus.":[78,133],"Assays":[79],"prevent":[81],"mild,":[83],"moderate":[84],"or":[85],"severe":[86],"risks":[87],"an":[89],"eventual":[90],"future":[91],"affecting":[93],"humans":[94],"are":[100],"now":[101],"being":[102],"carried":[103],"out":[104],"preparing":[106],"new":[107],"vaccines":[108],"neuraminidase":[110],"(=":[111],"sialidase)":[112],"inhibitors":[113],"such":[114,150],"as":[115,119,121,151],"oseltamivir":[116],"zanamivir,":[118],"well":[120],"other":[122],"agents":[123],"block":[125],"function":[127],"several":[129],"components":[130],"Recently,":[134],"been":[136],"debated":[137],"whether":[138],"would":[140],"convenient":[142],"use":[144],"modulators":[145],"system,":[149],"statins,":[152],"against":[153],"secondary":[155],"effects":[156],"viral":[159],"infection":[160],"cytokines,":[167],"reinforce":[169],"above":[171],"therapeutic":[172],"measures.":[173],"The":[174],"low":[175],"cost":[176],"statins":[178],"offers":[179],"additional":[180],"justification":[181],"for":[182],"their":[183],"use.":[184]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
