{"id":"https://openalex.org/W1485799704","doi":null,"title":"Clonidine inhibits vesico-sphincter reflexes in patients with chronic spinal lesions.","display_name":"Clonidine inhibits vesico-sphincter reflexes in patients with chronic spinal lesions.","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W1485799704","mag":"1485799704","pmid":"https://pubmed.ncbi.nlm.nih.gov/2059129"},"language":"en","primary_location":{"id":"pmid:2059129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2059129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of physical medicine and rehabilitation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109550644","display_name":"Richard M Herman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Herman","raw_affiliation_strings":["Samaritan Rehabilitation Institute, Phoenix, AZ 85006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samaritan Rehabilitation Institute, Phoenix, AZ 85006","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"M C Wainberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Wainberg","raw_affiliation_strings":["Samaritan Rehabilitation Institute, Phoenix, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samaritan Rehabilitation Institute, Phoenix, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9853,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8972951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"72","issue":"8","first_page":"539","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":1.0},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8230000138282776},{"id":"https://openalex.org/keywords/micturition-reflex","display_name":"micturition reflex","score":0.8420000076293945},{"id":"https://openalex.org/keywords/detrusor-contraction","display_name":"detrusor contraction","score":0.9169999957084656},{"id":"https://openalex.org/keywords/spasticity","display_name":"spasticity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/propriospinal-interneurons","display_name":"propriospinal interneurons","score":0.8349999785423279},{"id":"https://openalex.org/keywords/descending-inhibition","display_name":"descending inhibition","score":0.6639999747276306},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.8506275415420532},{"id":"https://openalex.org/C2781045395","wikidata":"https://www.wikidata.org/wiki/Q5319569","display_name":"Dyssynergia","level":3,"score":0.8120212554931641},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7300505042076111},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7154870629310608},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.7046408653259277},{"id":"https://openalex.org/C175768497","wikidata":"https://www.wikidata.org/wiki/Q105726","display_name":"Urination","level":3,"score":0.678168535232544},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6345446109771729},{"id":"https://openalex.org/C2779012798","wikidata":"https://www.wikidata.org/wiki/Q117060","display_name":"Spasticity","level":2,"score":0.6168952584266663},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5039488673210144},{"id":"https://openalex.org/C2780877482","wikidata":"https://www.wikidata.org/wiki/Q746416","display_name":"Sphincter","level":2,"score":0.4622810184955597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2454712688922882},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21903163194656372},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15680405497550964},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.14450854063034058},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001750","descriptor_name":"Urinary Bladder, Neurogenic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001750","descriptor_name":"Urinary Bladder, Neurogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004576","descriptor_name":"Electromyography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009128","descriptor_name":"Muscle Spasticity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2059129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2059129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of physical medicine and rehabilitation","raw_type":"Journal Article"},{"id":"mag:1485799704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2059129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W11560389","https://openalex.org/W96912105","https://openalex.org/W137547458","https://openalex.org/W144174057","https://openalex.org/W160026725","https://openalex.org/W193025105","https://openalex.org/W608829690","https://openalex.org/W1026468762","https://openalex.org/W1701645555","https://openalex.org/W1966238407","https://openalex.org/W1968790391","https://openalex.org/W1974618487","https://openalex.org/W1982324672","https://openalex.org/W1985799577","https://openalex.org/W1989617511","https://openalex.org/W1989738897","https://openalex.org/W1990227511","https://openalex.org/W2004173390","https://openalex.org/W2024520777","https://openalex.org/W2027727637","https://openalex.org/W2031545883","https://openalex.org/W2041873555","https://openalex.org/W2044511503","https://openalex.org/W2045323923","https://openalex.org/W2047200128","https://openalex.org/W2052756112","https://openalex.org/W2061695248","https://openalex.org/W2069455631","https://openalex.org/W2074842996","https://openalex.org/W2077916586","https://openalex.org/W2086475877","https://openalex.org/W2088221941","https://openalex.org/W2088331274","https://openalex.org/W2089572704","https://openalex.org/W2090901091","https://openalex.org/W2091411868","https://openalex.org/W2092560221","https://openalex.org/W2102136814","https://openalex.org/W2171740240","https://openalex.org/W2242025271","https://openalex.org/W2258034841","https://openalex.org/W2281263761","https://openalex.org/W2395757847","https://openalex.org/W2396333375","https://openalex.org/W2400220842","https://openalex.org/W2402282055","https://openalex.org/W2428791510","https://openalex.org/W2441438395","https://openalex.org/W2442402969","https://openalex.org/W2469860003","https://openalex.org/W3004021698"],"related_works":["https://openalex.org/W2281263761","https://openalex.org/W2027727637","https://openalex.org/W2623660433","https://openalex.org/W2025142941","https://openalex.org/W1800470624","https://openalex.org/W1939964914","https://openalex.org/W2022935391","https://openalex.org/W2084778187","https://openalex.org/W2002835117","https://openalex.org/W2146251641"],"abstract_inverted_index":{"When":[0],"administered":[1],"systemically":[2],"to":[3,19,24,33,135,137],"spinalized":[4],"animals,":[5],"clonidine,":[6],"the":[7,38,129,170],"prototypic":[8],"alpha":[9,140],"2":[10,141],"adrenergic":[11,142],"receptor":[12],"agonist,":[13],"purportedly":[14],"acts":[15],"at":[16],"spinal":[17,53,65,138,180],"sites":[18],"suppress":[20],"motor":[21,75,111,157],"responses":[22],"related":[23],"painful":[25],"peripheral":[26],"and":[27,30,32,55,73,85,103,147],"vesical":[28,54,105],"stimulation":[29],"spasticity,":[31],"improve":[34],"vesicourethral":[35],"coordination.":[36],"Hence,":[37],"action":[39],"of":[40,100,128,172],"clonidine":[41],"(400":[42],"micrograms":[43],"in":[44,48,60,94,126,169,176],"three":[45],"divided":[46],"doses":[47],"a":[49,91],"16-hour":[50],"span)":[51],"on":[52,145,160],"somatic":[56],"reflexes":[57,72,175],"was":[58],"examined":[59],"five":[61],"patients":[62,177],"with":[63,155,178],"suprasacral":[64],"cord":[66,139],"lesions":[67],"by":[68,83],"assessing":[69],"volume-induced":[70],"micturition":[71,174],"limb":[74],"discharges":[76,113],"that":[77],"occurred":[78],"spontaneously":[79],"or":[80],"were":[81,114,124],"elicited":[82],"noxious":[84],"nonnoxious":[86],"cutaneous":[87],"stimulation.":[88],"Clonidine":[89,164],"caused":[90],"significant":[92],"reduction":[93],"(1)":[95],"blood":[96],"pressure,":[97],"(2)":[98],"amplitude":[99],"detrusor":[101],"contraction,":[102],"(3)":[104],"external":[106],"urethral":[107],"sphincter":[108,162],"dyssynergia.":[109],"Limb":[110],"electromyography":[112],"not":[115],"markedly":[116],"attenuated,":[117],"although":[118],"spatiotemporal":[119],"changes":[120],"(eg,":[121],"irradiation,":[122],"after-discharges)":[123],"observed":[125],"some":[127],"patients.":[130],"The":[131],"results":[132],"are":[133],"ascribed":[134],"binding":[136],"receptors":[143],"located":[144],"segmental":[146],"intersegmental":[148],"(propriospinal)":[149],"interneurons,":[150],"released":[151],"from":[152],"descending":[153],"inhibition,":[154],"greater":[156],"system":[158],"specificity":[159],"striated":[161],"innervation.":[163],"may":[165],"be":[166],"clinically":[167],"effective":[168],"treatment":[171],"hyperactive":[173],"chronic":[179],"lesions.":[181]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}