{"id":"https://openalex.org/W1485629191","doi":null,"title":"Cytolytic potential of peripheral blood T-lymphocytes following adoptive immunotherapy with lymphokine-activated killer cells and low-dose interleukin 2.","display_name":"Cytolytic potential of peripheral blood T-lymphocytes following adoptive immunotherapy with lymphokine-activated killer cells and low-dose interleukin 2.","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W1485629191","mag":"1485629191","pmid":"https://pubmed.ncbi.nlm.nih.gov/1997188"},"language":"en","primary_location":{"id":"pmid:1997188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1997188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109393309","display_name":"Ichiro Yoshino","orcid":"https://orcid.org/0009-0003-4007-9606","observed_orcids":["https://orcid.org/0009-0003-4007-9606","https://orcid.org/0000-0001-6865-0104","https://orcid.org/0000-0002-7763-1850"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I Yoshino","raw_affiliation_strings":["Department of Virology, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103627260","display_name":"Tokujiro Yano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Murata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Murata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102093864","display_name":"Teruyoshi Ishida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ishida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057146510","display_name":"Keishi Sugimachi","orcid":"https://orcid.org/0000-0001-8768-5388","observed_orcids":["https://orcid.org/0000-0001-8768-5388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Sugimachi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103337189","display_name":"Genki Kimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113763602","display_name":"Kikuo Nomoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nomoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4369,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.8159803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"5","first_page":"1494","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/peripheral-blood-t-cells","display_name":"peripheral blood T cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/primary-lung-cancer","display_name":"primary lung cancer","score":0.7739999890327454},{"id":"https://openalex.org/keywords/nonspecific-cytotoxicity","display_name":"nonspecific cytotoxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/alpha-beta-t-cell-receptor","display_name":"alpha beta T cell receptor","score":0.6510000228881836},{"id":"https://openalex.org/keywords/anti-cd3-antibody","display_name":"anti-CD3 antibody","score":0.765999972820282},{"id":"https://openalex.org/keywords/hla-dr-expression","display_name":"HLA-DR expression","score":0.7699999809265137},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"interleukin-2 receptor","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2780126324","wikidata":"https://www.wikidata.org/wiki/Q612345","display_name":"Lymphocytosis","level":2,"score":0.6524220108985901},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.6306171417236328},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.5733128786087036},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5659798383712769},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5586310625076294},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5223789811134338},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.5121293067932129},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5108304023742676},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4769762456417084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4257640242576599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33119136095046997},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3077932596206665},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.2772187888622284},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.25369447469711304},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17668575048446655},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14390984177589417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015979","descriptor_name":"Killer Cells, Lymphokine-Activated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054353","descriptor_name":"Perforin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1997188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1997188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.1692","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.1692","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/51/5/1494.full.pdf","raw_type":"text"},{"id":"mag:1485629191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1997188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1530174196","https://openalex.org/W1562200810","https://openalex.org/W1568056581","https://openalex.org/W1625819322","https://openalex.org/W1975568557","https://openalex.org/W1978273241","https://openalex.org/W2024769127","https://openalex.org/W2027220453","https://openalex.org/W2053104174","https://openalex.org/W2065272367","https://openalex.org/W2075110532","https://openalex.org/W2086857441","https://openalex.org/W2107316949","https://openalex.org/W2119543617","https://openalex.org/W2132289909","https://openalex.org/W2179970611","https://openalex.org/W2240211010"],"related_works":["https://openalex.org/W7098178362","https://openalex.org/W2406127839","https://openalex.org/W2001117195","https://openalex.org/W2406051009","https://openalex.org/W1989044244","https://openalex.org/W2474603649","https://openalex.org/W2064558708","https://openalex.org/W2414371752","https://openalex.org/W7097567432","https://openalex.org/W2029598263"],"abstract_inverted_index":{"In":[0,47],"this":[1],"study,":[2],"we":[3],"investigated":[4],"the":[5,38,94,140,168],"cytolytic":[6,103,166],"activity":[7,75,104],"of":[8,40,49,54,64,91,96,105,170],"peripheral":[9,55,66],"blood":[10,56,67],"T-cells":[11],"(PBT)":[12],"obtained":[13],"from":[14],"nine":[15,50],"patients":[16,137],"with":[17,28,62,123],"primary":[18],"lung":[19],"cancer":[20],"treated":[21],"by":[22,146,156,174],"surgical":[23],"adjuvant":[24],"adoptive":[25],"immunotherapy":[26],"(AIT)":[27],"lymphokine-activated":[29],"killer":[30],"cells":[31,79,119],"and":[32,85,98],"low-dose":[33],"recombinant":[34],"interleukin":[35,99],"2":[36,100],"at":[37],"time":[39],"rebound":[41],"lymphocytosis":[42],"(24-48":[43],"h":[44],"after":[45],"AIT).":[46],"eight":[48],"patients,":[51],"nonspecific":[52],"cytotoxicity":[53,142],"lymphocytes":[57],"significantly":[58,109],"increased":[59,82],"as":[60],"compared":[61],"that":[63,152],"pre-AIT":[65],"lymphocytes.":[68],"However,":[69],"purified":[70],"PBT":[71,107,155],"showed":[72],"much":[73],"less":[74],"to":[76,115,176],"kill":[77],"tumor":[78,118,177],"although":[80],"they":[81,112,164],"in":[83,89,93,134,153],"number":[84],"were":[86,113],"activated":[87],"well":[88],"terms":[90],"increases":[92],"expression":[95],"HLA-DR":[97],"receptor.":[101],"The":[102,149],"post-AIT":[106],"was":[108,143,172],"enhanced":[110],"when":[111],"targeted":[114,141],"Fc":[116],"receptor-bearing":[117],"(K562":[120],"or":[121,126],"Daudi)":[122],"anti-CD3":[124],"(NU-T3)":[125],"anti-T-cell":[127],"receptor":[128],"(TCR)alpha":[129],"beta":[130],"(WT31)":[131],"monoclonal":[132],"antibody":[133],"all":[135],"five":[136],"examined.":[138],"Phenotypically,":[139],"predominantly":[144],"mediated":[145],"CD8+":[147],"cells.":[148,178],"results":[150],"indicated":[151],"vivo-activated":[154],"AIT":[157],"could":[158],"not":[159],"exhibit":[160],"direct":[161],"cytotoxicity,":[162],"but":[163],"acquired":[165],"potential,":[167],"effect":[169],"which":[171],"expressed":[173],"targeting":[175]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
