{"id":"https://openalex.org/W148551155","doi":null,"title":"31P magnetic resonance spectroscopy of animal uveal melanoma.","display_name":"31P magnetic resonance spectroscopy of animal uveal melanoma.","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W148551155","mag":"148551155","pmid":"https://pubmed.ncbi.nlm.nih.gov/2211022"},"language":"en","primary_location":{"id":"pmid:2211022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2211022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026884047","display_name":"John V. Kurhanewicz","orcid":"https://orcid.org/0000-0002-3544-5339","observed_orcids":["https://orcid.org/0000-0002-3544-5339"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Kurhanewicz","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004608008","display_name":"Sandra D. Winguth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S D Winguth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001050604","display_name":"Devron H. Char","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D H Char","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086939929","display_name":"Shawnya Kaleta\u2010Michaels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kaleta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050707428","display_name":"Nadine A. Kindy-Degnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Kindy-Degnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113659000","display_name":"Patrick S. Swift","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P S Swift","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052193047","display_name":"Paul R. Stauffer","orcid":"https://orcid.org/0000-0002-5025-6317","observed_orcids":["https://orcid.org/0000-0002-5025-6317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P R Stauffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108592933","display_name":"Michael F. Wendland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M F Wendland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029219277","display_name":"Alfred A. Lovato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Lovato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055110659","display_name":"Li\u2010Jen Chang","orcid":"https://orcid.org/0009-0007-0207-4520","observed_orcids":["https://orcid.org/0009-0007-0207-4520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L H Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.01734161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"9","first_page":"1745","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.9490000009536743},{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.3619999885559082},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.6499999761581421},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nucleoside-triphosphates","display_name":"nucleoside triphosphates","score":0.9079999923706055},{"id":"https://openalex.org/keywords/phosphomonoesters","display_name":"phosphomonoesters","score":0.9710000157356262},{"id":"https://openalex.org/keywords/spectroscopic-imaging","display_name":"spectroscopic imaging","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.44600000977516174},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.7609999775886536},{"id":"https://openalex.org/keywords/fibroblast-contamination","display_name":"fibroblast contamination","score":0.5149999856948853},{"id":"https://openalex.org/keywords/intratumoral-hemorrhage","display_name":"intratumoral hemorrhage","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7554947137832642},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6613423824310303},{"id":"https://openalex.org/C2776713392","wikidata":"https://www.wikidata.org/wiki/Q278859","display_name":"Uvea","level":3,"score":0.5920938849449158},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5903648138046265},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.5187137722969055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47419291734695435},{"id":"https://openalex.org/C2776352584","wikidata":"https://www.wikidata.org/wiki/Q418533","display_name":"Nucleoside triphosphate","level":4,"score":0.4444291293621063},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4405527114868164},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.4141640067100525},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.40825995802879333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3572293519973755},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2620283365249634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20399555563926697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20300951600074768},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.1164703369140625},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10728830099105835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07872888445854187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2211022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2211022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},{"id":"mag:148551155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2211022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1520716838","https://openalex.org/W1989700197","https://openalex.org/W1994769413","https://openalex.org/W2075548168","https://openalex.org/W2093164095"],"related_works":["https://openalex.org/W2158910460","https://openalex.org/W2090928875","https://openalex.org/W1988403047","https://openalex.org/W1982107550","https://openalex.org/W7554437","https://openalex.org/W7146378514","https://openalex.org/W2921420323","https://openalex.org/W32055505","https://openalex.org/W1987061031","https://openalex.org/W1994769413"],"abstract_inverted_index":{"Scleral":[0],"surface":[1],"coils":[2],"were":[3,31,57,101],"used":[4],"to":[5,87,108,116],"obtain":[6],"in":[7,17,40,136],"vivo":[8],"magnetic":[9],"resonance":[10],"spectra":[11,23,56],"(MRS)":[12],"of":[13,83,132,157],"Greene":[14],"melanoma":[15,140],"implanted":[16],"the":[18,34,93,143],"rabbit":[19],"uvea.":[20],"Well-localized":[21],"tumor":[22,35,60,76],"(4.7":[24],"Tesla)":[25],"with":[26,36,49,75],"good":[27],"signal-to-noise":[28],"ratios":[29,100],"(S/N)":[30],"obtained":[32,58],"from":[33,104,153],"a":[37],"\"single-pulse\"":[38],"sequence":[39],"less":[41],"than":[42],"1":[43],"hour.":[44],"Tumor":[45],"localization":[46],"was":[47,146],"confirmed":[48],"one-dimensional":[50],"spectroscopic":[51],"imaging":[52],"studies.":[53],"Serial":[54],"31P":[55,70,133],"during":[59],"growth":[61],"and":[62,66,79,98,112,160],"after":[63,90,142],"both":[64],"optimal":[65],"suboptimal":[67],"hyperthermia.":[68],"Early":[69],"MRS":[71,134],"change":[72],"is":[73],"correlated":[74],"treatment":[77],"response":[78],"preceded":[80],"histologic":[81],"evidence":[82],"cell":[84],"destruction.":[85],"Twenty-four":[86],"48":[88],"hours":[89],"successful":[91],"treatment,":[92],"inorganic":[94],"phosphate/nucleoside":[95],"triphosphate":[96],"(NTP),":[97],"phosphomonoester/NTP":[99],"significantly":[102],"increased":[103,151],"1.2":[105],"+/-":[106,110,114,118],"0.1":[107,111,115],"1.7":[109],"1.3":[113],"1.8":[117],"0.2,":[119],"respectively.":[120],"In":[121],"contrast,":[122],"untreated":[123],"or":[124],"ineffectively":[125],"treated":[126],"tumors":[127],"showed":[128],"little":[129],"change.":[130],"Interpretation":[131],"data":[135],"this":[137],"animal":[138],"uveal":[139],"model":[141],"first":[144],"week":[145],"complicated":[147],"by":[148],"decreased":[149],"S/N,":[150],"contamination":[152],"contiguous":[154],"tissues,":[155],"ingrowth":[156],"fibroblasts,":[158],"macrophages,":[159],"intratumor":[161],"hemorrhage.":[162]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}