{"id":"https://openalex.org/W1485423","doi":"https://doi.org/10.1006/taap.2000.8937","title":"\u03b3-Diketone Peripheral Neuropathy","display_name":"\u03b3-Diketone Peripheral Neuropathy","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W1485423","doi":"https://doi.org/10.1006/taap.2000.8937","mag":"1485423","pmid":"https://pubmed.ncbi.nlm.nih.gov/10828208"},"language":"en","primary_location":{"id":"doi:10.1006/taap.2000.8937","doi":"https://doi.org/10.1006/taap.2000.8937","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.2000.8937","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108483707","display_name":"Ellen J. Lehning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen J. Lehning","raw_affiliation_strings":["Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467-2490, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467-2490, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032100986","display_name":"Bernard S. Jortner","orcid":"https://orcid.org/0000-0002-3998-9018","observed_orcids":["https://orcid.org/0000-0002-3998-9018"]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard S. Jortner","raw_affiliation_strings":["Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Laboratory for Neurotoxicity Studies, Blacksburg, Virginia, 24061-0442"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Laboratory for Neurotoxicity Studies, Blacksburg, Virginia, 24061-0442","institution_ids":["https://openalex.org/I39822340","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034616232","display_name":"Jonathan H. Fox","orcid":"https://orcid.org/0000-0002-9311-5231","observed_orcids":["https://orcid.org/0000-0002-9311-5231"]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan H. Fox","raw_affiliation_strings":["Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Laboratory for Neurotoxicity Studies, Blacksburg, Virginia, 24061-0442"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Laboratory for Neurotoxicity Studies, Blacksburg, Virginia, 24061-0442","institution_ids":["https://openalex.org/I39822340","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073909635","display_name":"Joseph C. Arezzo","orcid":"https://orcid.org/0000-0001-8216-6490","observed_orcids":["https://orcid.org/0000-0001-8216-6490"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Arezzo","raw_affiliation_strings":["Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113483928","display_name":"T. Kitano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taka-aki Kitano","raw_affiliation_strings":["Department of Anesthesiology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita-gun, 8795593, Oita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita-gun, 8795593, Oita, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086388333","display_name":"Richard M. LoPachin","orcid":"https://orcid.org/0000-0003-1903-4908","observed_orcids":["https://orcid.org/0000-0003-1903-4908"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. LoPachin","raw_affiliation_strings":["Department of Anesthesiology, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, Bronx, New York, 10467-2490"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, Bronx, New York, 10467-2490","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.4668,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.81058207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"165","issue":"2","first_page":"127","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.427700012922287,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.427700012922287,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.08540000021457672,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-5-hexanedione","display_name":"2,5-hexanedione","score":0.9900000095367432},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.800000011920929},{"id":"https://openalex.org/keywords/axonal-swellings","display_name":"axonal swellings","score":0.8450000286102295},{"id":"https://openalex.org/keywords/myelinated-nerve-fibers","display_name":"myelinated axons","score":0.753000020980835},{"id":"https://openalex.org/keywords/dose-rate-effects","display_name":"dose rate dependence","score":0.574999988079071},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tibial-nerve","display_name":"tibial nerve","score":0.9700000286102295},{"id":"https://openalex.org/keywords/lumbar-spinal-nerves","display_name":"lumbar spinal nerves","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nerve-electrophysiology","display_name":"nerve electrophysiology","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.831113338470459},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.740869402885437},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6647689938545227},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6396496295928955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49326199293136597},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.4675304889678955},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.46387991309165955},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.44365787506103516},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.415442556142807},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4067908823490143},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38371413946151733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36894044280052185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3294503092765808},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28476011753082275},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1847212314605713},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006588","descriptor_name":"Hexanones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013979","descriptor_name":"Tibial Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018737","descriptor_name":"Hand Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/taap.2000.8937","doi":"https://doi.org/10.1006/taap.2000.8937","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.2000.8937","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:10828208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10828208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.699999988079071,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3518562852","display_name":"Molecular Mechanisms of Hexacarbon-Induced Axon Atrophy","funder_award_id":"R01ES007912","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W3712366","https://openalex.org/W21600353","https://openalex.org/W42850151","https://openalex.org/W641116124","https://openalex.org/W1549262474","https://openalex.org/W1587708872","https://openalex.org/W1643714861","https://openalex.org/W1855833533","https://openalex.org/W1899517605","https://openalex.org/W1934091276","https://openalex.org/W1964069971","https://openalex.org/W1965059994","https://openalex.org/W1969330915","https://openalex.org/W1969779705","https://openalex.org/W1972308707","https://openalex.org/W1977054468","https://openalex.org/W1978642981","https://openalex.org/W1980204643","https://openalex.org/W1982647438","https://openalex.org/W1990089665","https://openalex.org/W1994346924","https://openalex.org/W1997059459","https://openalex.org/W2001299036","https://openalex.org/W2015561107","https://openalex.org/W2016870828","https://openalex.org/W2018437963","https://openalex.org/W2023140356","https://openalex.org/W2028462956","https://openalex.org/W2028578858","https://openalex.org/W2035035597","https://openalex.org/W2038927612","https://openalex.org/W2044871842","https://openalex.org/W2048862091","https://openalex.org/W2049217100","https://openalex.org/W2054575157","https://openalex.org/W2056245395","https://openalex.org/W2057641785","https://openalex.org/W2061601812","https://openalex.org/W2062435555","https://openalex.org/W2062491883","https://openalex.org/W2062513416","https://openalex.org/W2063448600","https://openalex.org/W2066324278","https://openalex.org/W2069933698","https://openalex.org/W2071434138","https://openalex.org/W2071842306","https://openalex.org/W2074035248","https://openalex.org/W2081525624","https://openalex.org/W2082182998","https://openalex.org/W2083916407","https://openalex.org/W2083952664","https://openalex.org/W2087219846","https://openalex.org/W2087277002","https://openalex.org/W2089408760","https://openalex.org/W2093139589","https://openalex.org/W2094584212","https://openalex.org/W2100253056","https://openalex.org/W2101108802","https://openalex.org/W2101356420","https://openalex.org/W2105800847","https://openalex.org/W2106218338","https://openalex.org/W2133676988","https://openalex.org/W2155225566","https://openalex.org/W2159498587","https://openalex.org/W2281215693","https://openalex.org/W2291731596","https://openalex.org/W2322549208","https://openalex.org/W2396978591","https://openalex.org/W2423486792","https://openalex.org/W2440269347","https://openalex.org/W2605241914","https://openalex.org/W2794887821","https://openalex.org/W2912571754","https://openalex.org/W2956056620","https://openalex.org/W6601684472","https://openalex.org/W6635302022","https://openalex.org/W7073842063"],"related_works":["https://openalex.org/W2021740928","https://openalex.org/W2016081918","https://openalex.org/W2023983419","https://openalex.org/W4232769044","https://openalex.org/W2069933698","https://openalex.org/W2008336314","https://openalex.org/W2012258769","https://openalex.org/W2440269347","https://openalex.org/W2035035597","https://openalex.org/W2062491883"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
