{"id":"https://openalex.org/W1485065692","doi":"https://doi.org/10.1158/1538-7445.am2014-2573","title":"Abstract 2573: The immunocytokine NHS-IL12 as a potential cancer therapeutic","display_name":"Abstract 2573: The immunocytokine NHS-IL12 as a potential cancer therapeutic","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1485065692","doi":"https://doi.org/10.1158/1538-7445.am2014-2573","mag":"1485065692"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-2573","doi":"https://doi.org/10.1158/1538-7445.am2014-2573","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-2573","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056309213","display_name":"Jonathan K. Fallon","orcid":"https://orcid.org/0000-0002-9762-2783","observed_orcids":["https://orcid.org/0000-0002-9762-2783"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan K. Fallon","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023615653","display_name":"Robert Tighe","orcid":"https://orcid.org/0009-0005-8406-0709","observed_orcids":["https://orcid.org/0009-0005-8406-0709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Tighe","raw_affiliation_strings":["2EMD Serono, Billerica, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2EMD Serono, Billerica, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029719896","display_name":"Amanda J. Lyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda J. Lyon","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109110971","display_name":"Helen Sabzevari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Sabzevari","raw_affiliation_strings":["2EMD Serono, Billerica, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2EMD Serono, Billerica, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059931764","display_name":"Jeffrey Schlom","orcid":"https://orcid.org/0000-0001-7932-4072","observed_orcids":["https://orcid.org/0000-0001-7932-4072"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Schlom","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110820942","display_name":"John W. Greiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Greiner","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"2573","last_page":"2573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunocytokines","display_name":"immunocytokines","score":0.9350000023841858},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.890999972820282},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.8939999938011169},{"id":"https://openalex.org/keywords/radiation","display_name":"radiation","score":0.5019999742507935},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.7883974313735962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6140161752700806},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.46413037180900574},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4602817893028259},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4592691659927368},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45609864592552185},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43164968490600586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4203607141971588},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3751313388347626},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3507963716983795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2720802426338196},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.19996336102485657},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18529629707336426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10193660855293274},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08292555809020996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-2573","doi":"https://doi.org/10.1158/1538-7445.am2014-2573","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-2573","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1787996156","https://openalex.org/W2068913713","https://openalex.org/W4390674482","https://openalex.org/W3164078207","https://openalex.org/W4409191529","https://openalex.org/W2158616782","https://openalex.org/W2885230323","https://openalex.org/W4220753169","https://openalex.org/W4321324466","https://openalex.org/W2888060359"],"abstract_inverted_index":{"Abstract":[0],"Targeted":[1],"delivery":[2],"of":[3,47,59,89,91,112,170,226,231],"IL-12":[4,20,107],"might":[5],"make":[6],"this":[7,48,171],"cytokine":[8],"a":[9,22,144,164,175,192,219],"safer,":[10],"more":[11],"effective":[12],"cancer":[13,145,221],"therapeutic.":[14,222],"Here":[15],"we":[16],"evaluated":[17,190],"whether":[18],"fusing":[19],"to":[21,43,52,85],"tumor":[23,130],"necrosis-targeting":[24],"human":[25],"IgG1":[26],"(NHS76)":[27],"could":[28],"improve":[29],"its":[30],"anti-tumor":[31,57,109,119,137,153],"efficacy":[32,58],"in":[33,77,97,101,108,151,179,191],"vivo.":[34],"In":[35],"vivo":[36],"imaging":[37],"and":[38,66,76,80,100,178,184],"immunohistochemistry":[39],"staining":[40],"were":[41,83],"used":[42,84],"assess":[44],"the":[45,87,118,167,227,232],"ability":[46],"novel":[49],"immunocytokine":[50,94,216],"(NHS-IL12)":[51],"target":[53],"murine":[54],"tumors.":[55],"The":[56,215],"NHS-IL12":[60,104,133,141,186,217],"was":[61,95],"examined":[62],"at":[63],"various":[64],"doses":[65],"treatment":[67,134,142],"schedules.":[68],"Immune":[69],"cell":[70,114],"subset-depleting":[71],"antibodies,":[72],"flow":[73],"cytometric":[74],"methods,":[75],"vitro":[78],"cytotoxicity":[79],"ELISA":[81],"assays":[82],"investigate":[86],"mechanisms":[88],"action":[90],"NHS-IL12.":[92],"This":[93],"investigated":[96],"several":[98],"models":[99],"all":[102],"cases":[103],"outperformed":[105],"recombinant":[106],"activity.":[110],"Depletion":[111],"immune":[113],"subsets":[115],"revealed":[116],"that":[117,127],"activity":[120],"depends":[121],"primarily":[122],"on":[123],"CD8+":[124],"cells;":[125],"mice":[126],"had":[128],"complete":[129],"regression":[131],"following":[132],"displayed":[135],"durable":[136],"memory":[138],"responses.":[139],"Combining":[140],"with":[143,181],"vaccine,":[146],"radiation,":[147,183],"or":[148],"chemotherapy":[149],"resulted":[150],"greater":[152],"effects":[154],"than":[155],"each":[156],"individual":[157],"therapy":[158],"alone.":[159],"These":[160],"preclinical":[161],"findings":[162],"provide":[163],"rationale":[165],"for":[166,235],"clinical":[168,195],"testing":[169],"immunocytokine,":[172],"both":[173],"as":[174,218],"single":[176],"agent":[177],"combination":[180],"vaccines,":[182],"chemotherapy.":[185],"is":[187],"currently":[188],"being":[189],"Phase":[193],"1":[194],"trial":[196],"(NCT01417546).":[197],"Citation":[198],"Format:":[199],"Jonathan":[200],"K.":[201],"Fallon,":[202],"Robert":[203],"Tighe,":[204],"Amanda":[205],"J.":[206],"Lyon,":[207],"Helen":[208],"Sabzevari,":[209],"Jeffrey":[210],"Schlom,":[211],"John":[212],"W.":[213],"Greiner.":[214],"potential":[220],"[abstract].":[223],"In:":[224],"Proceedings":[225],"105th":[228],"Annual":[229],"Meeting":[230],"American":[233],"Association":[234],"Cancer":[236,247],"Research;":[237],"2014":[238],"Apr":[239],"5-9;":[240],"San":[241],"Diego,":[242],"CA.":[243],"Philadelphia":[244],"(PA):":[245],"AACR;":[246],"Res":[248],"2014;74(19":[249],"Suppl):Abstract":[250],"nr":[251],"2573.":[252],"doi:10.1158/1538-7445.AM2014-2573":[253]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}