{"id":"https://openalex.org/W1485043634","doi":"https://doi.org/10.1089/152308602753666370","title":"Modulation of Endothelial Cell Apoptosis by Heme Oxygenase-1-Derived Carbon Monoxide","display_name":"Modulation of Endothelial Cell Apoptosis by Heme Oxygenase-1-Derived Carbon Monoxide","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W1485043634","doi":"https://doi.org/10.1089/152308602753666370","mag":"1485043634","pmid":"https://pubmed.ncbi.nlm.nih.gov/12006183"},"language":"en","primary_location":{"id":"doi:10.1089/152308602753666370","doi":"https://doi.org/10.1089/152308602753666370","is_oa":false,"landing_page_url":"https://doi.org/10.1089/152308602753666370","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067643807","display_name":"Miguel Parreira Soares","orcid":"https://orcid.org/0000-0002-9314-4833","observed_orcids":["https://orcid.org/0000-0002-9314-4833"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT","US"],"is_corresponding":false,"raw_author_name":"Miguel P. Soares","raw_affiliation_strings":["Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A. and Instituto Gulbenkian de Ci\u00eancia, Apartado 14, 2781-901 Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A. and Instituto Gulbenkian de Ci\u00eancia, Apartado 14, 2781-901 Oeiras, Portugal","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018558610","display_name":"Anny Usheva","orcid":"https://orcid.org/0000-0003-3788-2425","observed_orcids":["https://orcid.org/0000-0003-3788-2425"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anny Usheva","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065386977","display_name":"Sophie Brouard","orcid":"https://orcid.org/0000-0002-6398-1315","observed_orcids":["https://orcid.org/0000-0002-6398-1315"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophie Brouard","raw_affiliation_strings":["Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009418325","display_name":"Pascal Oliver Berberat","orcid":"https://orcid.org/0000-0001-5022-5265","observed_orcids":["https://orcid.org/0000-0001-5022-5265"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pascal O. Berberat","raw_affiliation_strings":["Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059642738","display_name":"Lukas G\u00fcnther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lukas Gunther","raw_affiliation_strings":["Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076400614","display_name":"Edda Tobiasch","orcid":"https://orcid.org/0000-0002-5871-8408","observed_orcids":["https://orcid.org/0000-0002-5871-8408"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edda Tobiasch","raw_affiliation_strings":["Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113629670","display_name":"Fritz H. Bach","orcid":"https://orcid.org/0009-0000-3953-3363","observed_orcids":["https://orcid.org/0009-0000-3953-3363"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fritz H. Bach","raw_affiliation_strings":["Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115 Boston, MA, U.S.A","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.928,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.67155963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"2","first_page":"321","last_page":"329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9340000152587891},{"id":"https://openalex.org/keywords/antiapoptotic-genes","display_name":"anti-apoptotic genes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heme-degradation","display_name":"heme degradation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.8389716744422913},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.8048920631408691},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6313306093215942},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6067929267883301},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5521310567855835},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5320079922676086},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5060784220695496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48848187923431396},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.4693126678466797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3555889129638672},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33384057879447937},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21444278955459595},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.2127198874950409},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16553884744644165},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/152308602753666370","doi":"https://doi.org/10.1089/152308602753666370","is_oa":false,"landing_page_url":"https://doi.org/10.1089/152308602753666370","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},{"id":"pmid:12006183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12006183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1225817273","https://openalex.org/W1493971026","https://openalex.org/W1500284214","https://openalex.org/W1528925569","https://openalex.org/W1550443883","https://openalex.org/W1551093971","https://openalex.org/W1578996543","https://openalex.org/W1600690434","https://openalex.org/W1621595817","https://openalex.org/W1940059160","https://openalex.org/W1968861315","https://openalex.org/W1973081785","https://openalex.org/W1980272041","https://openalex.org/W1981165639","https://openalex.org/W1990698300","https://openalex.org/W1991300200","https://openalex.org/W1994780702","https://openalex.org/W1995117391","https://openalex.org/W1997507706","https://openalex.org/W2001019228","https://openalex.org/W2001333805","https://openalex.org/W2002022970","https://openalex.org/W2006199415","https://openalex.org/W2007986629","https://openalex.org/W2009183800","https://openalex.org/W2023189063","https://openalex.org/W2025128734","https://openalex.org/W2031923131","https://openalex.org/W2032731042","https://openalex.org/W2033914311","https://openalex.org/W2034184306","https://openalex.org/W2040125444","https://openalex.org/W2050690958","https://openalex.org/W2050920255","https://openalex.org/W2050971607","https://openalex.org/W2051478582","https://openalex.org/W2054698185","https://openalex.org/W2056580837","https://openalex.org/W2061497413","https://openalex.org/W2061903251","https://openalex.org/W2062567347","https://openalex.org/W2064510514","https://openalex.org/W2065101979","https://openalex.org/W2066033513","https://openalex.org/W2066389046","https://openalex.org/W2067739721","https://openalex.org/W2071055800","https://openalex.org/W2072410510","https://openalex.org/W2075610315","https://openalex.org/W2080621792","https://openalex.org/W2082355820","https://openalex.org/W2086567353","https://openalex.org/W2087047553","https://openalex.org/W2087450601","https://openalex.org/W2087516645","https://openalex.org/W2088764696","https://openalex.org/W2094334993","https://openalex.org/W2101575450","https://openalex.org/W2104892506","https://openalex.org/W2121486402","https://openalex.org/W2123513769","https://openalex.org/W2124595022","https://openalex.org/W2130866079","https://openalex.org/W2134771161","https://openalex.org/W2135325091","https://openalex.org/W2135772628","https://openalex.org/W2138966101","https://openalex.org/W2139319526","https://openalex.org/W2144701362","https://openalex.org/W2145287139","https://openalex.org/W2145530136","https://openalex.org/W2147678437","https://openalex.org/W2147921405","https://openalex.org/W2148308989","https://openalex.org/W2150792239","https://openalex.org/W2159650080","https://openalex.org/W2166803343","https://openalex.org/W2169486888","https://openalex.org/W2415108489","https://openalex.org/W4313343327"],"related_works":["https://openalex.org/W2166803343","https://openalex.org/W7099718616","https://openalex.org/W2158281895","https://openalex.org/W7098177542","https://openalex.org/W1500754345","https://openalex.org/W2334698509","https://openalex.org/W2136498526","https://openalex.org/W2148308989","https://openalex.org/W2319502026","https://openalex.org/W7095481795"],"abstract_inverted_index":{"It":[0],"is":[1,48],"well":[2,113],"established":[3],"that":[4,30,42,80],"expression":[5,32,116],"of":[6,18,46,84,90,103,117,120],"heme":[7,51],"oxygenase-1":[8],"(HO-1)":[9],"acts":[10,86],"in":[11,15,22],"a":[12,16,118],"cytoprotective":[13],"manner":[14],"variety":[17],"cell":[19],"types,":[20],"including":[21],"endothelial":[23],"cells":[24],"(EC).":[25],"We":[26,38,75],"have":[27,39],"recently":[28],"shown":[29,41],"HO-1":[31,47],"protects":[33],"EC":[34,73],"from":[35],"undergoing":[36],"apoptosis.":[37,74],"also":[40],"the":[43,54,64,81,88,91,101,104,115],"antiapoptotic":[44,82,123],"effect":[45,83],"mediated":[49],"through":[50,87],"catabolism":[52],"into":[53],"gas":[55],"carbon":[56],"monoxide":[57],"(CO).":[58],"In":[59],"this":[60],"review,":[61],"we":[62],"discuss":[63],"possible":[65],"molecular":[66],"mechanisms":[67],"by":[68],"which":[69],"HO-1-derived":[70],"CO":[71,85],"suppresses":[72],"will":[76],"review":[77],"data":[78],"suggesting":[79],"activation":[89,102],"p38":[92],"mitogen-activated":[93],"protein":[94],"kinase":[95],"signal":[96],"transduction":[97],"pathway":[98],"and":[99],"requires":[100],"transcription":[105],"factor":[106],"nuclear":[107],"factor-kappa":[108],"B":[109],"(NF-kappa":[110],"B),":[111],"as":[112,114],"subset":[119],"NF-kappa":[121],"B-dependent":[122],"genes.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}