{"id":"https://openalex.org/W1484978434","doi":null,"title":"Gene expression profile of epithelial cells and mesenchymal cells derived from limbal explant culture.","display_name":"Gene expression profile of epithelial cells and mesenchymal cells derived from limbal explant culture.","publication_year":2010,"publication_date":"2010-07-06","ids":{"openalex":"https://openalex.org/W1484978434","mag":"1484978434","pmid":"https://pubmed.ncbi.nlm.nih.gov/20664697","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903463"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2903463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903463","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090308770","display_name":"Naresh Polisetti","orcid":"https://orcid.org/0000-0001-8669-0388","observed_orcids":["https://orcid.org/0000-0001-8669-0388"]},"institutions":[{"id":"https://openalex.org/I2801255070","display_name":"L V Prasad Eye Institute","ror":"https://ror.org/01w8z9742","country_code":"IN","type":"funder","lineage":["https://openalex.org/I2801255070"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Naresh Polisetti","raw_affiliation_strings":["C-TRACER, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C-TRACER, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Hyderabad, India","institution_ids":["https://openalex.org/I2801255070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067957722","display_name":"Prasoon Agarwal","orcid":"https://orcid.org/0000-0003-1813-7606","observed_orcids":["https://orcid.org/0000-0003-1813-7606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prasoon Agarwal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041831885","display_name":"Imran Khan","orcid":"https://orcid.org/0000-0001-6888-7347","observed_orcids":["https://orcid.org/0000-0001-6888-7347","https://orcid.org/0000-0002-8764-2801","https://orcid.org/0000-0001-8428-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Imran Khan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020978468","display_name":"Paturu Kondaiah","orcid":"https://orcid.org/0000-0002-2159-1044","observed_orcids":["https://orcid.org/0000-0002-2159-1044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paturu Kondaiah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027451993","display_name":"Veena Sangwan","orcid":"https://orcid.org/0000-0002-8229-4158","observed_orcids":["https://orcid.org/0000-0002-8229-4158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virender S Sangwan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091306967","display_name":"Geeta Kashyap Vemuganti","orcid":"https://orcid.org/0000-0002-0432-2109","observed_orcids":["https://orcid.org/0000-0002-0432-2109"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geeta K Vemuganti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3653,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.90357881,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1227","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limbal-stem-cell-deficiency","display_name":"limbal stem cell deficiency","score":0.9589999914169312},{"id":"https://openalex.org/keywords/limbal-epithelial-cells","display_name":"limbal epithelial cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.7699999809265137},{"id":"https://openalex.org/keywords/limbal-stem-cell-niche","display_name":"limbal stem cell niche","score":0.7179999947547913},{"id":"https://openalex.org/keywords/limbal-stem-cell-transplantation","display_name":"limbal stem cell transplantation","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7954780459403992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7522570490837097},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5816020369529724},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5246517658233643},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5095439553260803},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5009500980377197},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.4601273238658905},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45172375440597534},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4415481388568878},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32753872871398926},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26125970482826233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1302272081375122}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016850","descriptor_name":"Limbus Corneae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2903463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:20664697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20664697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.iisc.ac.in:32124","doi":null,"is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/32124/1/gene.pdf","pdf_url":"http://eprints.iisc.ac.in/32124/1/gene.pdf","source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"mag:1484978434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20664697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2903463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W4313777","https://openalex.org/W41461433","https://openalex.org/W192938927","https://openalex.org/W1500473157","https://openalex.org/W1511400170","https://openalex.org/W1529716332","https://openalex.org/W1554268192","https://openalex.org/W1571382658","https://openalex.org/W1603508604","https://openalex.org/W1639665852","https://openalex.org/W1967957985","https://openalex.org/W1985175887","https://openalex.org/W1985760249","https://openalex.org/W1992744445","https://openalex.org/W1993739774","https://openalex.org/W2001729432","https://openalex.org/W2004972310","https://openalex.org/W2011145007","https://openalex.org/W2014015828","https://openalex.org/W2014269161","https://openalex.org/W2015971523","https://openalex.org/W2025616876","https://openalex.org/W2026314752","https://openalex.org/W2036607348","https://openalex.org/W2045334829","https://openalex.org/W2051241694","https://openalex.org/W2064702589","https://openalex.org/W2066793164","https://openalex.org/W2084442176","https://openalex.org/W2097942434","https://openalex.org/W2098274164","https://openalex.org/W2106584923","https://openalex.org/W2120327297","https://openalex.org/W2121062346","https://openalex.org/W2128078747","https://openalex.org/W2132984034","https://openalex.org/W2142608951","https://openalex.org/W2148308138","https://openalex.org/W2310287610","https://openalex.org/W2410369169"],"related_works":["https://openalex.org/W3006312582","https://openalex.org/W2076462677","https://openalex.org/W2068615414","https://openalex.org/W2529360205","https://openalex.org/W1516556489","https://openalex.org/W1972527895","https://openalex.org/W4409500472","https://openalex.org/W7100896456","https://openalex.org/W2750094967","https://openalex.org/W2213171049"],"abstract_inverted_index":{"PURPOSE:":[0],"Limbal":[1],"stem":[2,19,71],"cell":[3,20,50],"deficiency":[4],"is":[5],"a":[6,48],"challenging":[7],"clinical":[8],"problem":[9],"and":[10,95,97,117,134,136,144,161,167,185,188,198],"the":[11,16,40,76,150,154,173,195],"current":[12],"treatment":[13],"involves":[14],"replenishing":[15],"depleted":[17],"limbal":[18,25,32,180],"(LSC)":[21],"pool":[22],"by":[23,103,114],"either":[24],"tissue":[26],"transplantation":[27],"or":[28],"use":[29],"of":[30,38,56,59,79,132,153,179,202],"cultivated":[31],"epithelial":[33,184],"cells":[34,58,72,187],"(LEC).":[35],"Our":[36],"experience":[37],"cultivating":[39],"LEC":[41,133],"on":[42],"denuded":[43],"human":[44],"amniotic":[45],"membrane":[46],"using":[47,104,115],"feeder":[49],"free":[51],"method,":[52],"led":[53],"to":[54,66,142],"identification":[55],"mesenchymal":[57,70,186],"limbus":[60],"(MC-L),":[61],"which":[62],"showed":[63],"phenotypic":[64],"resemblance":[65],"bone":[67],"marrow":[68],"derived":[69,183],"(MSC-BM).":[73],"To":[74],"understand":[75],"transcriptional":[77],"profile":[78],"these":[80,203],"cells,":[81],"microarray":[82,98,110,126],"experiments":[83,99],"were":[84,100],"carried":[85,101],"out.":[86],"METHODS:":[87],"RNA":[88],"was":[89,112],"isolated":[90],"from":[91],"cultured":[92],"LEC,":[93],"MC-L":[94,166],"MSC-BM":[96],"out":[102],"Agilent":[105],"chip":[106],"(4x44":[107],"k).":[108],"The":[109,125],"data":[111],"validated":[113],"Realtime":[116],"semiquntitative":[118],"reverse":[119],"transcription":[120],"polymerase":[121],"chain":[122],"reaction.":[123],"RESULTS:":[124],"analysis":[127,178],"revealed":[128],"specific":[129],"gene":[130,163,176],"signature":[131],"MC-L,":[135],"also":[137,158],"their":[138],"complementary":[139],"role":[140],"related":[141],"cytokine":[143],"growth":[145],"factor":[146],"profile,":[147],"thus":[148],"supporting":[149],"nurturing":[151],"roles":[152],"MC-L.":[155],"We":[156],"have":[157],"observed":[159],"similar":[160],"differential":[162],"expression":[164,177],"between":[165],"MSC-BM.":[168],"CONCLUSIONS:":[169],"This":[170],"study":[171],"represents":[172],"first":[174],"extensive":[175],"explant":[181],"culture":[182],"as":[189],"such":[190],"reveals":[191],"new":[192],"insight":[193],"into":[194],"biology,":[196],"ontogeny,":[197],"in":[199],"vivo":[200],"function":[201],"cells.":[204]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
