{"id":"https://openalex.org/W148484416","doi":null,"title":"The role of platelet thrombin receptors PAR1 and PAR4 in health and disease","display_name":"The role of platelet thrombin receptors PAR1 and PAR4 in health and disease","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W148484416","mag":"148484416"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-71395","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71395","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71395","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001799148","display_name":"Martina Nylander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Martina Nylander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001799148"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/par1","display_name":"PAR1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/protease-activated-receptor-4","display_name":"PAR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protease-activated-receptors","display_name":"protease-activated receptors","score":0.8420000076293945},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.7200000286102295},{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gingipains","display_name":"gingipains","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8650000095367432},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.7300000190734863},{"id":"https://openalex.org/keywords/p2y12","display_name":"P2Y12","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pi-3-kinase","display_name":"PI3-kinase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9070000052452087},{"id":"https://openalex.org/keywords/platelet-secretion","display_name":"platelet secretion","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.8039385676383972},{"id":"https://openalex.org/C2776708134","wikidata":"https://www.wikidata.org/wiki/Q3655338","display_name":"Cangrelor","level":5,"score":0.7101187705993652},{"id":"https://openalex.org/C49059817","wikidata":"https://www.wikidata.org/wiki/Q14916330","display_name":"P2Y12","level":4,"score":0.7006092071533203},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6496343612670898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6310535669326782},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.6071435213088989},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5581386089324951},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5069737434387207},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4536927342414856},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44274991750717163},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.324924111366272},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29509657621383667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29362815618515015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17669379711151123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16178864240646362}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-71395","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71395","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:148484416","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.se/smash/get/diva2:448091/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-71395","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71395","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W158801599","https://openalex.org/W159699246","https://openalex.org/W174858232","https://openalex.org/W1234014522","https://openalex.org/W1489529085","https://openalex.org/W1530505052","https://openalex.org/W1564433957","https://openalex.org/W1602498852","https://openalex.org/W1657825487","https://openalex.org/W1658287483","https://openalex.org/W1741065974","https://openalex.org/W1830908113","https://openalex.org/W1837514060","https://openalex.org/W1861890207","https://openalex.org/W1874327317","https://openalex.org/W1899700659","https://openalex.org/W1905458504","https://openalex.org/W1944642365","https://openalex.org/W1964592398","https://openalex.org/W1966849446","https://openalex.org/W1970488832","https://openalex.org/W1971529415","https://openalex.org/W1972112385","https://openalex.org/W1972147469","https://openalex.org/W1973379750","https://openalex.org/W1973512297","https://openalex.org/W1974052300","https://openalex.org/W1979557307","https://openalex.org/W1981108184","https://openalex.org/W1982346511","https://openalex.org/W1988121084","https://openalex.org/W1989958005","https://openalex.org/W1990941291","https://openalex.org/W1991755293","https://openalex.org/W1992029300","https://openalex.org/W1992168784","https://openalex.org/W1995601334","https://openalex.org/W1998503733","https://openalex.org/W1999927753","https://openalex.org/W2001249418","https://openalex.org/W2005526270","https://openalex.org/W2007737411","https://openalex.org/W2008630818","https://openalex.org/W2012214760","https://openalex.org/W2016217548","https://openalex.org/W2017450138","https://openalex.org/W2017818484","https://openalex.org/W2022177860","https://openalex.org/W2022289790","https://openalex.org/W2027484984","https://openalex.org/W2030625703","https://openalex.org/W2030753117","https://openalex.org/W2031056943","https://openalex.org/W2031424136","https://openalex.org/W2033852349","https://openalex.org/W2036456076","https://openalex.org/W2036659707","https://openalex.org/W2037583192","https://openalex.org/W2039156905","https://openalex.org/W2043526402","https://openalex.org/W2043951336","https://openalex.org/W2048499949","https://openalex.org/W2048989975","https://openalex.org/W2058629481","https://openalex.org/W2070827349","https://openalex.org/W2071710501","https://openalex.org/W2072101129","https://openalex.org/W2074504036","https://openalex.org/W2075245112","https://openalex.org/W2078898236","https://openalex.org/W2079884282","https://openalex.org/W2081134652","https://openalex.org/W2081753893","https://openalex.org/W2083272472","https://openalex.org/W2084483224","https://openalex.org/W2084751893","https://openalex.org/W2086318374","https://openalex.org/W2086974577","https://openalex.org/W2088438515","https://openalex.org/W2090717137","https://openalex.org/W2091276080","https://openalex.org/W2091705825","https://openalex.org/W2095049732","https://openalex.org/W2095089544","https://openalex.org/W2095345326","https://openalex.org/W2095765250","https://openalex.org/W2102090574","https://openalex.org/W2104575856","https://openalex.org/W2105620704","https://openalex.org/W2106245550","https://openalex.org/W2110550137","https://openalex.org/W2119370402","https://openalex.org/W2121161379","https://openalex.org/W2126784673","https://openalex.org/W2126844603","https://openalex.org/W2128142528","https://openalex.org/W2132905504","https://openalex.org/W2133427224","https://openalex.org/W2133664523","https://openalex.org/W2134647197","https://openalex.org/W2140962000","https://openalex.org/W2141260882","https://openalex.org/W2141674983","https://openalex.org/W2143442358","https://openalex.org/W2144015687","https://openalex.org/W2152393435","https://openalex.org/W2155919744","https://openalex.org/W2156070710","https://openalex.org/W2157518434","https://openalex.org/W2159023925","https://openalex.org/W2161488081","https://openalex.org/W2161831003","https://openalex.org/W2162084919","https://openalex.org/W2163170969","https://openalex.org/W2166769021","https://openalex.org/W2169182236","https://openalex.org/W2224161487","https://openalex.org/W2336672206","https://openalex.org/W2340316837","https://openalex.org/W2394602136","https://openalex.org/W2403525833","https://openalex.org/W2405944457","https://openalex.org/W2408685360","https://openalex.org/W2409654730","https://openalex.org/W2410145381","https://openalex.org/W2411476619","https://openalex.org/W2435153524","https://openalex.org/W2464967924","https://openalex.org/W7214235793"],"related_works":["https://openalex.org/W108327721","https://openalex.org/W94754891","https://openalex.org/W7033688581","https://openalex.org/W149121501","https://openalex.org/W2091112630","https://openalex.org/W4240566081","https://openalex.org/W7097815478","https://openalex.org/W2591907900","https://openalex.org/W2099967664","https://openalex.org/W2095089544"],"abstract_inverted_index":{"Blood":[0],"cells":[1],"are":[2,28],"continuously":[3],"flowing":[4],"in":[5,10,24,87,111,121,247,331,347,363,388,404],"our":[6],"systems":[7],"maintaining":[8],"haemostasis":[9],"the":[11,20,25,32,36,44,48,65,77,88,96,99,137,170,173,184,203,212,251,293,351,379,397],"arteries":[12],"and":[13,34,68,82,109,134,136,177,189,227,245,269,280,328,334,350,366,378,382,401,411],"veins.":[14],"If":[15],"a":[16,62,84,218,254,309,326,344,359],"vessel":[17],"is":[18,76,83,93,157,187,273],"damaged,":[19],"smallest":[21],"cell":[22,281],"fragments":[23],"blood":[26,40,49,66],"(platelets)":[27],"directed":[29],"to":[30,38,60,149,232,260,264,291,299,392],"cover":[31],"wound":[33],"plug":[35],"leakage":[37],"prevent":[39],"loss.":[41],"Most":[42],"of":[43,211,253,262,353,396],"time":[45],"platelets":[46,58,312],"stop":[47],"leak":[50],"without":[51],"any":[52],"difficulties.":[53],"During":[54],"other,":[55],"pathological,":[56],"circumstances,":[57],"continue":[59],"form":[61],"thrombus,":[63],"preventing":[64],"flow":[67],"may":[69],"cause":[70],"myocardial":[71],"infarction":[72],"or":[73],"stroke.":[74],"Thrombin":[75],"most":[78,294],"potent":[79],"platelet":[80,101,198,255,267,332,364,375,398,412],"agonist":[81],"product":[85],"created":[86],"coagulation":[89],"cascade.":[90],"This":[91,318,368],"thesis":[92,240,319,339,369,390],"focused":[94],"on":[95,202,275],"interactions":[97,131,373],"between":[98,118,132,172,243,374],"two":[100,314],"thrombin":[102,178,296,316,376,399],"receptors;":[103],"protease":[104],"activated":[105],"receptors":[106,120,377,400],"1":[107],"(PAR1)":[108],"PAR4":[110,135,182,246,258,324,342],"vitro.":[112],"We":[113],"have":[114],"investigated":[115,197],"potential":[116],"differences":[117,242],"these":[119],"several":[122,321],"situations":[123,322,405],"associated":[124],"with":[125,146,200],"cardiovascular":[126],"disease.":[127],"First":[128],"we":[129,152,222],"studied":[130],"PAR1":[133,235,244,287,357],"oral":[138],"pathogen":[139],"Porphyromonas":[140],"gingivalis":[141,156],"(which":[142],"secretes":[143],"enzymes,":[144],"gingipains,":[145],"properties":[147],"similar":[148],"thrombin).":[150],"Here":[151,221],"showed":[153,168,223],"that":[154,169,224,270,341],"P.":[155],"signaling":[158,282,333,349],"mainly,":[159],"but":[160],"not":[161],"exclusively,":[162],"via":[163,278,283],"PAR4.":[164,237],"Our":[165],"second":[166],"study":[167,196],"cross-talk":[171],"stress":[174],"hormone":[175],"epinephrine":[176,383],"occur":[179],"exclusively":[180],"through":[181,234],"if":[183],"key-substance":[185],"ATP":[186],"present":[188],"cyclooxygenase-1":[190],"inhibited":[191],"by":[192],"aspirin.":[193],"The":[194,385],"third":[195],"secretion,":[199],"focus":[201],"protein":[204],"plasminogen":[205],"activator":[206],"inhibitor":[207,210],"1(PAI-1),":[208],"an":[209,393],"fibrinolytic":[213],"process":[214],"responsible":[215],"for":[216,303],"dissolving":[217],"formed":[219],"clot.":[220],"PAI-1":[225],"secretion":[226,365],"synthesis":[228],"was":[229],"more":[230,360],"sensitive":[231],"stimulation":[233],"than":[236],"Finally":[238],"this":[239,271,338,389],"describes":[241],"cell-signaling":[248],"pathways":[249],"regulating":[250],"stability":[252,272],"aggregate,":[256],"where":[257,323],"seems":[259],"be":[261,292,308],"importance":[263],"create":[265],"stable":[266],"aggregates":[268],"dependent":[274],"ADP":[276],"activation":[277],"P2Y12":[279],"PI3-kinase.":[284],"Until":[285],"now,":[286],"has":[288],"been":[289],"considered":[290],"important":[295,329],"receptor,":[297],"due":[298],"its":[300],"high":[301],"affinity":[302],"thrombin.":[304],"However,":[305],"there":[306],"must":[307],"reason":[310],"why":[311],"express":[313],"different":[315],"receptors.":[317,384],"highlights":[320],"plays":[325,343],"complementary":[327],"role":[330,346,362],"haemostasis.":[335],"In":[336],"conclusion,":[337],"suggests":[340],"major":[345],"calcium":[348],"induction":[352],"sustained":[354],"aggregation,":[355],"while":[356],"shows":[358],"prominent":[361],"synthesis.":[367],"also":[370],"reveals":[371],"new":[372],"ADP-,":[380],"ATP-":[381],"results":[386],"described":[387],"contribute":[391],"increased":[394],"knowledge":[395],"their":[402],"interplay":[403],"such":[406],"as":[407],"infection,":[408],"stress,":[409],"fibrinolysis,":[410],"aggregation.":[413]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}