{"id":"https://openalex.org/W1484809697","doi":"https://doi.org/10.1002/0471142301.ns0612s10","title":"Voltage Clamp Recordings from Xenopus Oocytes","display_name":"Voltage Clamp Recordings from Xenopus Oocytes","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W1484809697","doi":"https://doi.org/10.1002/0471142301.ns0612s10","mag":"1484809697","pmid":"https://pubmed.ncbi.nlm.nih.gov/18428511"},"language":"en","primary_location":{"id":"doi:10.1002/0471142301.ns0612s10","doi":"https://doi.org/10.1002/0471142301.ns0612s10","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142301.ns0612s10","pdf_url":null,"source":{"id":"https://openalex.org/S4210168458","display_name":"Current Protocols in Neuroscience","issn_l":"1934-8576","issn":["1934-8576","1934-8584"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054988954","display_name":"Nathan Dascal","orcid":"https://orcid.org/0000-0002-5397-4146","observed_orcids":["https://orcid.org/0000-0002-5397-4146"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Nathan Dascal","raw_affiliation_strings":["Tel Aviv University  Ramat Aviv Israel","Tel-Aviv University Ramat Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel Aviv University  Ramat Aviv Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Tel-Aviv University Ramat Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054988954"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":5050,"currency":"USD","value_usd":5050},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.07013665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"Unit 6.12","last_page":"Unit 6.12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenopus-oocytes","display_name":"Xenopus oocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/two-electrode-voltage-clamp","display_name":"two-electrode voltage clamp","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.6539999842643738},{"id":"https://openalex.org/keywords/heterologous-expression","display_name":"heterologous expression","score":0.9309999942779541},{"id":"https://openalex.org/keywords/whole-cell-recording","display_name":"whole-cell recording","score":0.578000009059906},{"id":"https://openalex.org/keywords/recording-accuracy","display_name":"recording accuracy","score":0.36399999260902405},{"id":"https://openalex.org/keywords/ion-channel-pharmacology","display_name":"ion channel pharmacology","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.9424327611923218},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.7787679433822632},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.753839910030365},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.6810727119445801},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5754414796829224},{"id":"https://openalex.org/C108305142","wikidata":"https://www.wikidata.org/wiki/Q3062286","display_name":"Heterologous expression","level":4,"score":0.5703058242797852},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4578801989555359},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.43440529704093933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.431287556886673},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40747615694999695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3839789628982544},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3686163127422333},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32329729199409485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2903241515159607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15484082698822021},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.13911482691764832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/0471142301.ns0612s10","doi":"https://doi.org/10.1002/0471142301.ns0612s10","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142301.ns0612s10","pdf_url":null,"source":{"id":"https://openalex.org/S4210168458","display_name":"Current Protocols in Neuroscience","issn_l":"1934-8576","issn":["1934-8576","1934-8584"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Neuroscience","raw_type":"journal-article"},{"id":"pmid:18428511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18428511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current protocols in neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W26722646","https://openalex.org/W51509680","https://openalex.org/W1494190088","https://openalex.org/W1881994315","https://openalex.org/W1947692468","https://openalex.org/W1973662152","https://openalex.org/W1996602639","https://openalex.org/W2002455415","https://openalex.org/W2007960627","https://openalex.org/W2009667219","https://openalex.org/W2016582329","https://openalex.org/W2025852280","https://openalex.org/W2043779911","https://openalex.org/W2046153683","https://openalex.org/W2059084665","https://openalex.org/W2059831112","https://openalex.org/W2060281923","https://openalex.org/W2061523258","https://openalex.org/W2061858869","https://openalex.org/W2069847823","https://openalex.org/W2099727280","https://openalex.org/W2101625991","https://openalex.org/W2108799394","https://openalex.org/W2115047895","https://openalex.org/W2143502290","https://openalex.org/W2150136880","https://openalex.org/W2199386566","https://openalex.org/W2323956997"],"related_works":["https://openalex.org/W2059831112","https://openalex.org/W4281482299","https://openalex.org/W2358995494","https://openalex.org/W2902337863","https://openalex.org/W3127069326","https://openalex.org/W2363368974","https://openalex.org/W3044812170","https://openalex.org/W2012635677","https://openalex.org/W2131381401","https://openalex.org/W2383405945"],"abstract_inverted_index":{"Xenopus":[0,96],"oocytes":[1,97],"serve":[2],"as":[3,51,53],"a":[4],"standard":[5,54],"heterologous":[6],"expression":[7,26],"system":[8,87],"for":[9,23,98],"the":[10,44,62,70,83,86,93],"study":[11],"of":[12,19,29,31,72,78,85,95,102],"cloned":[13],"ion":[14,33,103],"channels.":[15,104],"The":[16],"large":[17],"size":[18,64],"these":[20],"cells":[21],"allows":[22],"relatively":[24],"easy":[25],"and":[27,74],"recording":[28,79,90],"activity":[30],"exogenous":[32],"channels":[34],"(together":[35],"with":[36,88],"neurotransmitter":[37],"receptors":[38],"and/or":[39],"various":[40],"regulatory":[41],"proteins)":[42],"using":[43],"whole-cell":[45],"two-electrode":[46],"voltage":[47],"clamp":[48,57],"(TEVC)":[49],"technique,":[50],"well":[52],"single-channel":[55],"patch":[56],"recordings.":[58],"Although":[59],"usually":[60],"advantageous,":[61],"cell":[63],"also":[65],"dictates":[66],"certain":[67],"limits":[68],"on":[69],"accuracy":[71],"recordings":[73],"requires":[75],"specific":[76],"modifications":[77],"methods.":[80],"However,":[81],"combining":[82],"advantages":[84],"available":[89],"methods":[91],"enables":[92],"use":[94],"sophisticated":[99],"multidisciplinary":[100],"studies":[101]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-09-18T07:38:42.748307","created_date":"2016-06-24T00:00:00"}