{"id":"https://openalex.org/W1484778424","doi":"https://doi.org/10.5772/56867","title":"Targets and Approaches to Control Hepatocellular Carcinoma in Future","display_name":"Targets and Approaches to Control Hepatocellular Carcinoma in Future","publication_year":2013,"publication_date":"2013-10-23","ids":{"openalex":"https://openalex.org/W1484778424","doi":"https://doi.org/10.5772/56867","mag":"1484778424"},"language":"en","primary_location":{"id":"doi:10.5772/56867","doi":"https://doi.org/10.5772/56867","is_oa":true,"landing_page_url":"https://doi.org/10.5772/56867","pdf_url":"https://www.intechopen.com/chapters/45541","source":{"id":"https://openalex.org/S4306463447","display_name":"InTech eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatocellular Carcinoma - Future Outlook","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2497244865","display_name":"Hepatocellular Carcinoma - Future Outlook"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.intechopen.com/chapters/45541","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103337013","display_name":"Mukherjee Biswajit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mukherjee Biswajit","raw_affiliation_strings":["Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India","institution_ids":["https://openalex.org/I170979836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111421742","display_name":"Hossain Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hossain Chowdhury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062021314","display_name":"Sanchari Bhattacharya","orcid":"https://orcid.org/0000-0002-8958-0077","observed_orcids":["https://orcid.org/0000-0002-8958-0077"]},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhattacharya Sanchari","raw_affiliation_strings":["Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India","institution_ids":["https://openalex.org/I170979836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020041600","display_name":"Shampa Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shampa Ghosh","raw_affiliation_strings":["Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India","institution_ids":["https://openalex.org/I170979836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6052,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.74545455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/cancer-control","display_name":"cancer control","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4519999921321869},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.6380000114440918},{"id":"https://openalex.org/keywords/tumor-histology","display_name":"tumor histology","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8130987882614136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2611032724380493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21803587675094604}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5772/56867","doi":"https://doi.org/10.5772/56867","is_oa":true,"landing_page_url":"https://doi.org/10.5772/56867","pdf_url":"https://www.intechopen.com/chapters/45541","source":{"id":"https://openalex.org/S4306463447","display_name":"InTech eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatocellular Carcinoma - Future Outlook","raw_type":"book-chapter"},{"id":"pmh:oai:biblioboard.com:7bb97b63-96db-4d7e-92dd-0d797ac1fb95","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/7bb97b63-96db-4d7e-92dd-0d797ac1fb95","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-6d55e02e354:IntechOpen","raw_type":"CHAPTER"},{"id":"pmh:oai:intechopen.com:45541","doi":null,"is_oa":true,"landing_page_url":"http://www.intechopen.com/articles/show/title/targets-and-approaches-to-control-hepatocellular-carcinoma-in-future","pdf_url":null,"source":{"id":"https://openalex.org/S4306401291","display_name":"Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210154139","host_organization_name":"Intech (Slovakia)","host_organization_lineage":["https://openalex.org/I4210154139"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.intechopen.com/download/pdf/pdfs_id/45541","raw_type":"06"}],"best_oa_location":{"id":"doi:10.5772/56867","doi":"https://doi.org/10.5772/56867","is_oa":true,"landing_page_url":"https://doi.org/10.5772/56867","pdf_url":"https://www.intechopen.com/chapters/45541","source":{"id":"https://openalex.org/S4306463447","display_name":"InTech eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatocellular Carcinoma - Future Outlook","raw_type":"book-chapter"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1484778424.pdf","grobid_xml":"https://content.openalex.org/works/W1484778424.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W136437443","https://openalex.org/W1502747696","https://openalex.org/W1816833887","https://openalex.org/W1964023019","https://openalex.org/W1968039618","https://openalex.org/W1970060716","https://openalex.org/W1971837077","https://openalex.org/W1972734309","https://openalex.org/W1974116204","https://openalex.org/W1975293227","https://openalex.org/W1981406217","https://openalex.org/W1985664048","https://openalex.org/W1987578671","https://openalex.org/W1988257756","https://openalex.org/W1988475963","https://openalex.org/W1994193851","https://openalex.org/W1995811009","https://openalex.org/W1995958786","https://openalex.org/W1998146257","https://openalex.org/W1998817605","https://openalex.org/W1999867233","https://openalex.org/W1999928502","https://openalex.org/W2001789614","https://openalex.org/W2003244782","https://openalex.org/W2004936600","https://openalex.org/W2008330784","https://openalex.org/W2008822062","https://openalex.org/W2009671859","https://openalex.org/W2010855371","https://openalex.org/W2015772717","https://openalex.org/W2015878656","https://openalex.org/W2017322644","https://openalex.org/W2020531037","https://openalex.org/W2028061232","https://openalex.org/W2029336551","https://openalex.org/W2035515735","https://openalex.org/W2037699867","https://openalex.org/W2046623913","https://openalex.org/W2051213986","https://openalex.org/W2054730738","https://openalex.org/W2055112967","https://openalex.org/W2056498057","https://openalex.org/W2057378223","https://openalex.org/W2061150173","https://openalex.org/W2068714011","https://openalex.org/W2075141288","https://openalex.org/W2084940271","https://openalex.org/W2090664023","https://openalex.org/W2091571370","https://openalex.org/W2101937389","https://openalex.org/W2102854363","https://openalex.org/W2106036268","https://openalex.org/W2107118102","https://openalex.org/W2111288662","https://openalex.org/W2113000404","https://openalex.org/W2114029473","https://openalex.org/W2115497785","https://openalex.org/W2118471405","https://openalex.org/W2121895505","https://openalex.org/W2124618775","https://openalex.org/W2124677916","https://openalex.org/W2126422295","https://openalex.org/W2126660554","https://openalex.org/W2128882591","https://openalex.org/W2134338345","https://openalex.org/W2136977965","https://openalex.org/W2137258698","https://openalex.org/W2140830323","https://openalex.org/W2143385760","https://openalex.org/W2144264656","https://openalex.org/W2145858013","https://openalex.org/W2151269408","https://openalex.org/W2161558746","https://openalex.org/W2163403599","https://openalex.org/W2166310425","https://openalex.org/W2166805191","https://openalex.org/W2169778089","https://openalex.org/W2244192859","https://openalex.org/W2325791202","https://openalex.org/W3139763557","https://openalex.org/W3149449331"],"related_works":["https://openalex.org/W2167923914","https://openalex.org/W4245869172","https://openalex.org/W1985068428","https://openalex.org/W1480358499","https://openalex.org/W3109933446","https://openalex.org/W2191527310","https://openalex.org/W2071264409","https://openalex.org/W2513903309","https://openalex.org/W1603163252","https://openalex.org/W7099044834"],"abstract_inverted_index":{"Cancer":[0,58],"is":[1,59,80,159],"uncontrolled":[2],"proliferation":[3],"of":[4,11,24,33,38,69,120,127,133,174,183],"cells,":[5,103],"which":[6,114,135],"results":[7],"from":[8,106],"the":[9,31,48,98,176,181],"loss":[10],"proper":[12],"balance":[13],"10":[14],"between":[15],"cell":[16,19,53,56],"death":[17,54],"and":[18,55,178,180,191,193],"growth.":[20],"The":[21,122],"transformed":[22],"phenotypes":[23],"cancer":[25,158],"cells":[26,123,146],"are":[27],"caused":[28],"by":[29,161],"11":[30],"accumulation":[32],"mutations":[34,128],"in":[35,46,141,168,198],"a":[36,44,60,67,81,107,111,117,125,130,142,199],"variety":[37],"genes":[39,134],"whose":[40],"products":[41],"normally":[42],"play":[43],"role":[45],"12":[47],"biochemical":[49,190],"pathways":[50],"that":[51,144],"regulate":[52],"proliferation.":[57],"broad":[61],"term":[62],"13":[63],"used":[64],"to":[65,129,138],"define":[66],"group":[68],"more":[70],"than":[71],"250":[72],"different":[73],"diseases":[74],"(Roncalli":[75],"et":[76,88,92,150,154],"al.":[77,89,93,151,155],"2010).":[78],"It":[79],"slow":[82],"14":[83],"multi-stage,":[84],"multi-step":[85],"process":[86],"(Camma":[87],"2008;":[90],"Calvisi":[91,153],"2009;":[94,152],"Sherman":[95],"2011).":[96],"In":[97],"15":[99],"first":[100],"instance,":[101],"these":[102],"derived":[104],"initially":[105],"normal":[108,145],"cell,":[109],"form":[110],"primary":[112],"tumor":[113],"16":[115],"comprises":[116],"growth-transformed":[118],"population":[119],"cells.":[121],"acquire":[124],"set":[126,132],"17":[131],"allow":[136],"them":[137],"divide":[139],"repeatedly":[140],"way":[143],"cannot":[147],"18":[148],"(Besaratinia":[149],"2009).":[156],"Histologically,":[157],"characterized":[160],"several":[162,188],"19":[163],"morphological":[164],"alterations,":[165],"including":[166],"changes":[167],"tissue":[169],"architecture,":[170],"cytological":[171],"abnormalities":[172],"20":[173],"both":[175],"nucleus":[177],"cytoplasm":[179],"presence":[182],"abnormal":[184],"mitoses.":[185],"A":[186],"stepwise":[187],"21":[189],"genetic":[192],"biological":[194],"alterations":[195],"eventually":[196],"result":[197],"cancer.":[200],"22":[201]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}