{"id":"https://openalex.org/W14846715","doi":"https://doi.org/10.1007/978-1-4684-6003-2_8","title":"Cooperative Mechanisms in the Regulation of Smooth Muscle Contraction","display_name":"Cooperative Mechanisms in the Regulation of Smooth Muscle Contraction","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W14846715","doi":"https://doi.org/10.1007/978-1-4684-6003-2_8","mag":"14846715","pmid":"https://pubmed.ncbi.nlm.nih.gov/1803924"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4684-6003-2_8","doi":"https://doi.org/10.1007/978-1-4684-6003-2_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4684-6003-2_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W570311158","display_name":"Regulation of Smooth Muscle Contraction"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060584405","display_name":"Marion J. Siegman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marion J. Siegman","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Philadelphia, PA 19107","Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Philadelphia, PA 19107","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111573688","display_name":"Thomas M. Butler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Butler","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022741153","display_name":"Tapan B. Vyas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tapan Vyas","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111573261","display_name":"Susan U. Mooers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan U. Mooers","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059354524","display_name":"Srinivasa R. Narayan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivasa Narayan","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Philadelphia, PA, 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":null,"apc_paid":null,"fwci":2.6697,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.88013699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"304","issue":null,"first_page":"77","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myosin-light-chain-phosphorylation","display_name":"myosin light chain phosphorylation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cross-bridge-cycling","display_name":"cross-bridge cycling","score":0.7099999785423279},{"id":"https://openalex.org/keywords/force-maintenance","display_name":"force maintenance","score":0.45100000500679016},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.6970000267028809},{"id":"https://openalex.org/keywords/isometric-contraction","display_name":"isometric contraction","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2776329151","wikidata":"https://www.wikidata.org/wiki/Q4683968","display_name":"CrossBridge","level":3,"score":0.9293329119682312},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.7619408965110779},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7574553489685059},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.7398980259895325},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5707510113716125},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.556259274482727},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.5514184832572937},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5180604457855225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5046297311782837},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4897332191467285},{"id":"https://openalex.org/C18923293","wikidata":"https://www.wikidata.org/wiki/Q6819942","display_name":"Meromyosin","level":5,"score":0.4657704532146454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4598333537578583},{"id":"https://openalex.org/C15954220","wikidata":"https://www.wikidata.org/wiki/Q24780076","display_name":"Myosin head","level":4,"score":0.3984167277812958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35293108224868774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3330478072166443},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17146089673042297},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.14507514238357544},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12965896725654602}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4684-6003-2_8","doi":"https://doi.org/10.1007/978-1-4684-6003-2_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4684-6003-2_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:1803924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1803924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2332269284","display_name":"STRUCTURE, FUNCTION &MECHANISM OF CONTRACTILE PROTEINS","funder_award_id":"5p01hl015835-30","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G251651929","display_name":"FUNCTIONAL ADAPTATIONS OF INTESTINAL SMOOTH MUSCLE","funder_award_id":"5r01dk037598-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2710772862","display_name":null,"funder_award_id":"HL 15835","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4541344982","display_name":null,"funder_award_id":"DK-37598","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W177747808","https://openalex.org/W637668684","https://openalex.org/W1508582984","https://openalex.org/W1611945579","https://openalex.org/W1863186034","https://openalex.org/W1971990081","https://openalex.org/W1973528551","https://openalex.org/W2013930024","https://openalex.org/W2022915605","https://openalex.org/W2063008299","https://openalex.org/W2100263021","https://openalex.org/W2124030784","https://openalex.org/W2142139403","https://openalex.org/W2153324572","https://openalex.org/W2408583342","https://openalex.org/W2414535593","https://openalex.org/W2422557916","https://openalex.org/W2427677046","https://openalex.org/W2475362550","https://openalex.org/W3126314488"],"related_works":["https://openalex.org/W2325931973","https://openalex.org/W2047092891","https://openalex.org/W3215260990","https://openalex.org/W1488840872","https://openalex.org/W2414121984","https://openalex.org/W2118471443","https://openalex.org/W1767643083","https://openalex.org/W2409467888","https://openalex.org/W1986180699","https://openalex.org/W2063008299"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}