{"id":"https://openalex.org/W14846186","doi":null,"title":"Desensitization of the acute inflammatory response in skin and mammary gland of sheep.","display_name":"Desensitization of the acute inflammatory response in skin and mammary gland of sheep.","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W14846186","mag":"14846186","pmid":"https://pubmed.ncbi.nlm.nih.gov/3596638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453386"},"language":"en","primary_location":{"id":"pmid:3596638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3596638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453386/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050032752","display_name":"PJCM Maas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Maas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062485291","display_name":"Ian G. Colditz","orcid":"https://orcid.org/0000-0001-9497-5148","observed_orcids":["https://orcid.org/0000-0001-9497-5148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I G Colditz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7317,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.68786478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"61","issue":"2","first_page":"215","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.8259999752044678},{"id":"https://openalex.org/keywords/acute-inflammatory-response","display_name":"acute inflammatory response","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.5210000276565552},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.972000002861023},{"id":"https://openalex.org/keywords/skin","display_name":"skin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/zymosan-activated-plasma","display_name":"zymosan-activated plasma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/oyster-glycogen","display_name":"oyster glycogen","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neutrophil-accumulation","display_name":"neutrophil accumulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/plasma-leakage","display_name":"plasma leakage","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cross-desensitization","display_name":"cross-desensitization","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7023658156394958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.684086799621582},{"id":"https://openalex.org/C51296783","wikidata":"https://www.wikidata.org/wiki/Q1645498","display_name":"Microgram","level":3,"score":0.6717844009399414},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.6294621229171753},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.6225274801254272},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.4694017469882965},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.46610862016677856},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.4588509202003479},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.4402041435241699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3936586081981659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.353704571723938},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07533571124076843},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008413","descriptor_name":"Mastitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008413","descriptor_name":"Mastitis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015054","descriptor_name":"Zymosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3596638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3596638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1453386","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453386/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:14846186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3596638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453386","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453386/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W148010989","https://openalex.org/W283389292","https://openalex.org/W1511204912","https://openalex.org/W1621147098","https://openalex.org/W1966889578","https://openalex.org/W1970618091","https://openalex.org/W1993513435","https://openalex.org/W2002972970","https://openalex.org/W2052327108","https://openalex.org/W2089961321","https://openalex.org/W2109943355","https://openalex.org/W2131542566","https://openalex.org/W2411490441"],"related_works":["https://openalex.org/W2070589100","https://openalex.org/W1621147098","https://openalex.org/W2062687486","https://openalex.org/W2027782841","https://openalex.org/W2031412741","https://openalex.org/W2181335938","https://openalex.org/W2034737979","https://openalex.org/W7097654469","https://openalex.org/W2417311473","https://openalex.org/W2413750039"],"abstract_inverted_index":{"Desensitization":[0],"of":[1,13,19,55,75,89,100,144,160,164,169,173,248,264,272],"the":[2,8,28,95,101,139,209,246,265,270],"inflammatory":[3,25,68,110,257,266],"response":[4,30,97,103,267],"was":[5,57,133,191],"investigated":[6],"in":[7,24,46,51,59,112,127,155,177,188,240,255],"mammary":[9],"glands":[10,61,114,156],"and":[11,35,42,44,79,171,183,202,224,237],"skin":[12,178,242],"sheep.":[14],"Following":[15],"twice":[16],"daily":[17,73],"stimulation":[18],"non-lactating":[20,60],"glands,":[21,67],"neutrophil":[22,85,235,252],"concentrations":[23],"exudates":[26],"during":[27],"seventh":[29],"to":[31,138,147,193,217],"endotoxin":[32,76,150,182,201,223],"(1":[33,38,77],"microgram)":[34,78],"zymosan-activated":[36],"plasma":[37,174,212,238,249],"ml)":[39],"were":[40,70,119,175],"30%":[41],"20%":[43],"those":[45],"primary":[47,122,194,256],"responses":[48,69,111,123],"occurring":[49],"concurrently":[50],"contralateral":[52,113],"glands.":[53,130],"Cross-desensitization":[54],"ZAP":[56],"found":[58],"pretreated":[62],"with":[63,94,121,181,245],"endotoxin.":[64,167],"In":[65],"lactating":[66],"examined":[71,176],"following":[72,87],"infusion":[74,88,159],"oyster":[80,184,206,230],"glycogen":[81],"(50":[82],"mg).":[83],"The":[84,142,232,259],"influx":[86],"each":[90],"agent":[91],"declined":[92],"linearly,":[93],"fourth":[96],"being":[98],"16%":[99],"first":[102],"for":[104,200,205,222,229],"both":[105],"agents.":[106],"On":[107,208],"Day":[108,125,220,227],"5,":[109],"receiving":[115],"an":[116],"initial":[117],"challenge":[118],"comparable":[120,192],"on":[124,251],"1":[126,148],"repeatedly":[128],"stimulated":[129],"Thus,":[131],"desensitization":[132,263],"a":[134,161],"local":[135],"phenomenon":[136],"restricted":[137],"restimulated":[140,180,189,241],"gland.":[141],"return":[143,216],"normal":[145,218],"responsiveness":[146],"microgram":[149],"occurred":[151],"after":[152,196,226],"9":[153],"days":[154,199,204],"desensitized":[157],"by":[158],"single":[162],"dose":[163],"50":[165],"micrograms":[166],"Accumulation":[168],"neutrophils":[170],"leakage":[172,213,239,250],"sites":[179],"glycogen.":[185,207,231],"Neutrophil":[186],"accumulation":[187,236],"lesions":[190,195,243],"about":[197],"3.5":[198],"4.5":[203],"other":[210],"hand,":[211],"did":[214],"not":[215],"until":[219,225],"8":[221],"10":[228],"dissociation":[233],"between":[234],"contrasts":[244],"dependence":[247],"migration":[253],"reported":[254],"lesions.":[258],"results":[260],"suggest":[261],"that":[262],"may":[268],"influence":[269],"pathogenesis":[271],"bacterial":[273],"infection.":[274]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}