{"id":"https://openalex.org/W1484550878","doi":"https://doi.org/10.1016/s0021-9258(17)44301-8","title":"Continuous estrogen exposure in the rat does not induce loss of uterine estrogen receptor.","display_name":"Continuous estrogen exposure in the rat does not induce loss of uterine estrogen receptor.","publication_year":1983,"publication_date":"1983-10-01","ids":{"openalex":"https://openalex.org/W1484550878","doi":"https://doi.org/10.1016/s0021-9258(17)44301-8","mag":"1484550878","pmid":"https://pubmed.ncbi.nlm.nih.gov/6619144"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)44301-8","doi":"https://doi.org/10.1016/s0021-9258(17)44301-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44301-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)44301-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112150304","display_name":"R. Jakesz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Jakesz","raw_affiliation_strings":["From the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110205473","display_name":"Attan Kasid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Kasid","raw_affiliation_strings":["From the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028539104","display_name":"Marc E. Lippman","orcid":"https://orcid.org/0000-0001-5280-4084","observed_orcids":["https://orcid.org/0000-0001-5280-4084"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Lippman","raw_affiliation_strings":["From the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.0937,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.86791753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"258","issue":"19","first_page":"11798","last_page":"11806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uterine-estrogen-receptor","display_name":"uterine estrogen receptor","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cytosolic-estrogen-receptor","display_name":"cytosolic estrogen receptor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nuclear-estrogen-receptor","display_name":"nuclear estrogen receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8619999885559082},{"id":"https://openalex.org/keywords/receptor-dissociation-kinetics","display_name":"receptor dissociation kinetics","score":0.6650000214576721},{"id":"https://openalex.org/keywords/rat-uterus","display_name":"rat uterus","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6677932739257812},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.665510356426239},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6355434656143188},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6276851296424866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6228601932525635},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6203238368034363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6109060049057007},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5196481943130493},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.455024778842926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2602001428604126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16942384839057922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09335029125213623},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.060550421476364136},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090204","descriptor_name":"Mesothelin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)44301-8","doi":"https://doi.org/10.1016/s0021-9258(17)44301-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44301-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6619144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6619144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)44301-8","doi":"https://doi.org/10.1016/s0021-9258(17)44301-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44301-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W9479973","https://openalex.org/W25072916","https://openalex.org/W156611903","https://openalex.org/W167038568","https://openalex.org/W1039759598","https://openalex.org/W1497865291","https://openalex.org/W1501788884","https://openalex.org/W1510840911","https://openalex.org/W1544928360","https://openalex.org/W1546940155","https://openalex.org/W1574229173","https://openalex.org/W1574719993","https://openalex.org/W1618332249","https://openalex.org/W1775749144","https://openalex.org/W1811094195","https://openalex.org/W1864176760","https://openalex.org/W1906197854","https://openalex.org/W1969197892","https://openalex.org/W1970619340","https://openalex.org/W1978432676","https://openalex.org/W1981416927","https://openalex.org/W1985761707","https://openalex.org/W1986165465","https://openalex.org/W1995832802","https://openalex.org/W1996154154","https://openalex.org/W1998183746","https://openalex.org/W2007254213","https://openalex.org/W2010306336","https://openalex.org/W2011737061","https://openalex.org/W2018011614","https://openalex.org/W2021751968","https://openalex.org/W2023405117","https://openalex.org/W2027999016","https://openalex.org/W2039172078","https://openalex.org/W2050586961","https://openalex.org/W2058094425","https://openalex.org/W2065790268","https://openalex.org/W2069549067","https://openalex.org/W2075935250","https://openalex.org/W2080133788","https://openalex.org/W2083454223","https://openalex.org/W2086823657","https://openalex.org/W2103283518","https://openalex.org/W2112824591","https://openalex.org/W2127503812","https://openalex.org/W2208707498"],"related_works":["https://openalex.org/W1546940155","https://openalex.org/W2002138499","https://openalex.org/W1966440144","https://openalex.org/W2095038015","https://openalex.org/W2036851095","https://openalex.org/W2001378770","https://openalex.org/W2333888500","https://openalex.org/W1970619340","https://openalex.org/W2014943128","https://openalex.org/W2414346108"],"abstract_inverted_index":{"Cytosol":[0],"estrogen":[1,6],"receptor":[2,7,26,57,175,273,285,300],"(ERc)":[3],"and":[4,64,89,100,196,238,259,305],"nuclear":[5,260,306],"(ERN)":[8],"levels":[9,49,66],"were":[10,53,98],"investigated":[11,99],"in":[12,80,108,156,185,257,299,302],"rat":[13],"uteri":[14,119],"under":[15],"different":[16,104,174],"conditions":[17],"of":[18,23,34,50,74,87,94,141,147,184,252,280],"hormonal":[19,84,96,142,282],"exposure.":[20,85],"The":[21],"amount":[22],"directly":[24],"assayable":[25],"was":[27,44,262],"closely":[28],"related":[29],"to":[30,46,55,102,149,188,202,264],"the":[31,70,75,253],"serum":[32,48],"concentration":[33],"17":[35],"beta-[2,4,6,7-3H]":[36],"estradiol":[37,189],"(":[38],"[3H]E2).":[39],"A":[40],"double":[41],"injection":[42,123,209],"technique":[43],"established":[45],"maintain":[47],"[3H]E2":[51,164],"which":[52],"sufficient":[54],"saturate":[56],"sites.":[58],"Under":[59],"these":[60,109],"conditions,":[61],"stable":[62],"ERC":[63,88,117,130,137,160,179],"ERN":[65,90,204,213,221,245],"are":[67],"maintained":[68],"throughout":[69],"study":[71],"period.":[72],"30%":[73],"total":[76,271],"ER":[77],"remains":[78],"cytoplasmic":[79,304],"localization":[81],"despite":[82],"continuous":[83,95,281],"Properties":[86],"after":[91,114,122,134,138,163,181,207,217],"6":[92,132,139,182,205,228,278],"h":[93,133,140,183,206,229,279],"exposure":[97,143,187],"found":[101,107],"be":[103,265],"from":[105,118],"receptors":[106],"subcellular":[110],"compartments":[111,307],"30":[112,120,161,215,225],"min":[113,121,162,216,226],"hormone":[115,135,208],"injections.":[116],"showed":[124,144,190,232,246],"a":[125,145,157,167,289],"faster":[126,211],"sedimentation":[127],"coefficient":[128],"than":[129,212],"prepared":[131],"treatment.":[136,218,283],"reduction":[146],"binding":[148],"calf":[150],"thymus":[151],"DNA":[152],"adsorbed":[153],"on":[154],"cellulose":[155],"cell-free":[158],"system.":[159],"treatment":[165,231],"had":[166],"biphasic":[168,233],"dissociation":[169,193,234],"pattern":[170],"consistent":[171],"with":[172],"two":[173],"populations,":[176],"whereas":[177,242],"uterine":[178],"obtained":[180,214,222],"vivo":[186],"virtually":[191,247],"no":[192,248],"at":[194,224,236],"22":[195,237],"28":[197,239],"degrees":[198,240],"C.":[199],"In":[200],"contrast":[201],"ERC,":[203],"sedimented":[210],"KCl":[219,243],"extractable":[220],"either":[223],"or":[227],"posthormone":[230],"kinetics":[235],"C,":[241],"nonextractable":[244],"dissociation.":[249],"Virtually":[250],"all":[251],"specifically":[254],"bound":[255],"ligand":[256],"cytosol":[258],"preparations":[261],"proven":[263],"authentic":[266],"E2.":[267],"We":[268],"conclude":[269],"that":[270],"cellular":[272],"is":[274,287],"quantitatively":[275],"conserved":[276],"during":[277],"Nuclear":[284],"loss":[286],"not":[288],"requisite":[290],"for":[291],"receptor-mediated":[292],"steroid":[293],"function,":[294],"although":[295],"important":[296],"time-dependent":[297],"changes":[298],"properties":[301],"both":[303],"do":[308],"occur.":[309]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}