{"id":"https://openalex.org/W1484550746","doi":"https://doi.org/10.1074/jbc.c100417200","title":"A Role for NF-\u03baB in the Induction of \u03b2-R1 by Interferon-\u03b2","display_name":"A Role for NF-\u03baB in the Induction of \u03b2-R1 by Interferon-\u03b2","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W1484550746","doi":"https://doi.org/10.1074/jbc.c100417200","mag":"1484550746","pmid":"https://pubmed.ncbi.nlm.nih.gov/11591697"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.c100417200","doi":"https://doi.org/10.1074/jbc.c100417200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c100417200","pdf_url":"http://www.jbc.org/article/S0021925819826194/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819826194/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061274578","display_name":"M.R. Sandhya Rani","orcid":"https://orcid.org/0009-0009-1344-2012","observed_orcids":["https://orcid.org/0009-0009-1344-2012"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.R. Sandhya Rani","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047966562","display_name":"Ashok Rajappa Asthagiri","orcid":"https://orcid.org/0000-0001-8230-5999","observed_orcids":["https://orcid.org/0000-0001-8230-5999"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashok R. Asthagiri","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073998861","display_name":"Aakash Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aakash Singh","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032897491","display_name":"Nywana Sizemore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nywana Sizemore","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039708837","display_name":"Swati S. Sathe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swati S. Sathe","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxia Li","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066313762","display_name":"Joseph A. DiDonato","orcid":"https://orcid.org/0000-0002-1641-1758","observed_orcids":["https://orcid.org/0000-0002-1641-1758"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. DiDonato","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080998429","display_name":"George Robert Stark","orcid":"https://orcid.org/0000-0002-8776-9597","observed_orcids":["https://orcid.org/0000-0002-8776-9597"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George R. Stark","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034732141","display_name":"Richard M. Ransohoff","orcid":"https://orcid.org/0000-0003-0175-6910","observed_orcids":["https://orcid.org/0000-0003-0175-6910"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard M. Ransohoff","raw_affiliation_strings":["Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034732141"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9653,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.71589931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"276","issue":"48","first_page":"44365","last_page":"44368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.30300000309944153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9229999780654907},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9419999718666077},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/ikappabalpha-super-repressor","display_name":"I\u03baB\u03b1 super-repressor","score":0.8080000281333923},{"id":"https://openalex.org/keywords/nf-kappab-p65-phosphorylation","display_name":"p65 phosphorylation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/promoter-transactivation","display_name":"promoter transactivation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.7360000014305115},{"id":"https://openalex.org/keywords/gene-induction","display_name":"gene induction","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.8845633268356323},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.727778971195221},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5828490853309631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5756301879882812},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.5623992681503296},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5323904752731323},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5081970691680908},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.5077720284461975},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4836536645889282},{"id":"https://openalex.org/C191163429","wikidata":"https://www.wikidata.org/wiki/Q20970205","display_name":"Sp3 transcription factor","level":5,"score":0.4800059199333191},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4765903651714325},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4197940528392792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37839359045028687},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.37792330980300903},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31574833393096924},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15544497966766357},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14287689328193665},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050832","descriptor_name":"Interferon-Stimulated Gene Factor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050834","descriptor_name":"Interferon-Stimulated Gene Factor 3, gamma Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.c100417200","doi":"https://doi.org/10.1074/jbc.c100417200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c100417200","pdf_url":"http://www.jbc.org/article/S0021925819826194/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11591697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11591697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"mag:2187644245","doi":null,"is_oa":false,"landing_page_url":"https://www.jbc.org/content/276/48/44365.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/jbc.c100417200","doi":"https://doi.org/10.1074/jbc.c100417200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c100417200","pdf_url":"http://www.jbc.org/article/S0021925819826194/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5062867232","display_name":"Integrated EGFR function in cytokine-driven inflammation and cancer","funder_award_id":"P01CA062220","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1484550746.pdf","grobid_xml":"https://content.openalex.org/works/W1484550746.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1497553226","https://openalex.org/W1526656160","https://openalex.org/W1576499008","https://openalex.org/W1604852883","https://openalex.org/W1605977136","https://openalex.org/W1915074145","https://openalex.org/W1925157258","https://openalex.org/W1969929211","https://openalex.org/W1997865069","https://openalex.org/W2006470470","https://openalex.org/W2008529421","https://openalex.org/W2023565096","https://openalex.org/W2029275361","https://openalex.org/W2042347911","https://openalex.org/W2059851697","https://openalex.org/W2063126618","https://openalex.org/W2112435732","https://openalex.org/W2115779497","https://openalex.org/W2119218166","https://openalex.org/W2134812217","https://openalex.org/W2144639685","https://openalex.org/W2150878299","https://openalex.org/W2169053713","https://openalex.org/W2324992364","https://openalex.org/W2435616154","https://openalex.org/W4313331142","https://openalex.org/W4313342412"],"related_works":["https://openalex.org/W2187644245","https://openalex.org/W1983733845","https://openalex.org/W2069659862","https://openalex.org/W1481656940","https://openalex.org/W1993168708","https://openalex.org/W2112004939","https://openalex.org/W1966028027","https://openalex.org/W9610411","https://openalex.org/W1968987342","https://openalex.org/W2049909535"],"abstract_inverted_index":{"Previous":[0],"experiments":[1],"have":[2],"suggested":[3],"that":[4,28,82],"induction":[5,56],"of":[6,39,50,57,67,74,85,89,97,110],"the":[7,45,75,86,98,108,113],"beta-R1":[8,46,59,99],"gene":[9,18],"by":[10],"interferon":[11],"(IFN)-beta":[12],"required":[13,93],"transcription":[14,96],"factor":[15],"ISGF-3":[16],"(IFN-stimulated":[17],"factor-3)":[19],"and":[20],"an":[21,40,51],"additional":[22],"component.":[23,36],"We":[24],"now":[25],"provide":[26,103],"evidence":[27],"nuclear":[29],"factor-kappaB":[30],"(NF-kappaB)":[31],"can":[32],"serve":[33],"as":[34],"this":[35],"Site-directed":[37],"mutagenesis":[38],"NF-kappaB":[41,68,77,90,111],"binding":[42],"site":[43],"in":[44,112],"promoter":[47],"or":[48],"over-expression":[49],"IkappaBalpha":[52],"super-repressor":[53],"abrogated":[54],"IFN-beta-mediated":[55,83],"a":[58,104],"promoter-reporter.":[60],"IFN-beta":[61],"treatment":[62],"did":[63,70],"not":[64],"augment":[65],"abundance":[66],"but":[69],"lead":[71],"to":[72,116],"phosphorylation":[73],"p65":[76],"subunit.":[78],"It":[79],"is":[80,92],"proposed":[81],"enhancement":[84],"transactivation":[87],"competence":[88],"components":[91],"for":[94],"inducible":[95],"promoter.":[100],"These":[101],"results":[102],"novel":[105],"insight":[106],"into":[107],"role":[109],"transcriptional":[114],"response":[115],"IFN-beta.":[117]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
