{"id":"https://openalex.org/W1484424873","doi":null,"title":"Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels.","display_name":"Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1484424873","mag":"1484424873","pmid":"https://pubmed.ncbi.nlm.nih.gov/17583180","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994037"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1994037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994037","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014610774","display_name":"Jutta Dierkes","orcid":"https://orcid.org/0000-0003-0663-877X","observed_orcids":["https://orcid.org/0000-0003-0663-877X"]},"institutions":[{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jutta Dierkes","raw_affiliation_strings":["Institute of Clinical Chemistry and Biochemistry, University Hospital Magdeburg, Germany. jutta.dierkes@medizin.uni-magdeburg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Biochemistry, University Hospital Magdeburg, Germany. jutta.dierkes@medizin.uni-magdeburg.de","institution_ids":["https://openalex.org/I4210138551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042254954","display_name":"Claus H. Luley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claus Luley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002413830","display_name":"Sabine Westphal","orcid":"https://orcid.org/0000-0002-5846-3345","observed_orcids":["https://orcid.org/0000-0002-5846-3345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Westphal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7645,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.88237602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"3","issue":"1","first_page":"99","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-homocysteine","display_name":"plasma homocysteine","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fibrates","display_name":"fibrates","score":0.9330000281333923},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8429999947547913},{"id":"https://openalex.org/keywords/niacin","display_name":"nicotinic acid","score":0.8360000252723694},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.8920000195503235},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.781000018119812},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.9670000076293945},{"id":"https://openalex.org/keywords/homocysteine-metabolism","display_name":"homocysteine metabolism","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.8850855827331543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8058923482894897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5556438565254211},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5389400720596313},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.5339044332504272},{"id":"https://openalex.org/C2776362216","wikidata":"https://www.wikidata.org/wiki/Q577387","display_name":"Bezafibrate","level":2,"score":0.44827696681022644},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4384695887565613},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.33110326528549194},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.2911144495010376}],"mesh":[{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1994037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},{"id":"pmid:17583180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17583180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular health and risk management","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.3166","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.3166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c0/6e/Vasc_Health_Risk_Manag_2007_Feb_3(1)_99-108.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:19915e68847c43edbed532692f7567ae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/19915e68847c43edbed532692f7567ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vascular Health and Risk Management, Vol Volume 3, Pp 99-108 (2007)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1994037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W65486890","https://openalex.org/W127488809","https://openalex.org/W152448817","https://openalex.org/W1485967434","https://openalex.org/W1521959273","https://openalex.org/W1601416041","https://openalex.org/W1966292733","https://openalex.org/W1967300297","https://openalex.org/W1968517325","https://openalex.org/W1968584268","https://openalex.org/W1975357252","https://openalex.org/W1976556685","https://openalex.org/W1977357923","https://openalex.org/W1987334179","https://openalex.org/W1992490342","https://openalex.org/W1995931698","https://openalex.org/W1996233154","https://openalex.org/W1999294727","https://openalex.org/W1999405539","https://openalex.org/W2003592725","https://openalex.org/W2003602721","https://openalex.org/W2008263647","https://openalex.org/W2009469473","https://openalex.org/W2011477467","https://openalex.org/W2013114262","https://openalex.org/W2014793094","https://openalex.org/W2017580205","https://openalex.org/W2023407130","https://openalex.org/W2027796972","https://openalex.org/W2030245503","https://openalex.org/W2032084625","https://openalex.org/W2033228105","https://openalex.org/W2036704593","https://openalex.org/W2040429583","https://openalex.org/W2047308783","https://openalex.org/W2049166220","https://openalex.org/W2051912351","https://openalex.org/W2053358292","https://openalex.org/W2054447090","https://openalex.org/W2058715260","https://openalex.org/W2061762222","https://openalex.org/W2063506869","https://openalex.org/W2063543638","https://openalex.org/W2064331595","https://openalex.org/W2064535286","https://openalex.org/W2066258649","https://openalex.org/W2067316789","https://openalex.org/W2068672773","https://openalex.org/W2068979118","https://openalex.org/W2070087261","https://openalex.org/W2077247955","https://openalex.org/W2078578691","https://openalex.org/W2079408175","https://openalex.org/W2084416591","https://openalex.org/W2087219735","https://openalex.org/W2088121802","https://openalex.org/W2093943353","https://openalex.org/W2095359243","https://openalex.org/W2097556746","https://openalex.org/W2098009451","https://openalex.org/W2099822840","https://openalex.org/W2107577035","https://openalex.org/W2115353211","https://openalex.org/W2125756592","https://openalex.org/W2126112014","https://openalex.org/W2129460144","https://openalex.org/W2134373686","https://openalex.org/W2137131186","https://openalex.org/W2144001768","https://openalex.org/W2145102352","https://openalex.org/W2145849976","https://openalex.org/W2146410661","https://openalex.org/W2152211449","https://openalex.org/W2152867825","https://openalex.org/W2153350988","https://openalex.org/W2154566023","https://openalex.org/W2154615092","https://openalex.org/W2161048144","https://openalex.org/W2162407733","https://openalex.org/W2163021746","https://openalex.org/W2167744816","https://openalex.org/W2198678228","https://openalex.org/W2230430502","https://openalex.org/W2249928430","https://openalex.org/W2317172136","https://openalex.org/W2323783182","https://openalex.org/W2396819930","https://openalex.org/W2400712338","https://openalex.org/W2411933642","https://openalex.org/W2412987363","https://openalex.org/W3145726055","https://openalex.org/W3146468648","https://openalex.org/W4236245800","https://openalex.org/W4243572601"],"related_works":["https://openalex.org/W2091399496","https://openalex.org/W3151497322","https://openalex.org/W1982667981","https://openalex.org/W2092517363","https://openalex.org/W2412987363","https://openalex.org/W2149129425","https://openalex.org/W4366239800","https://openalex.org/W2053358292","https://openalex.org/W2063543638","https://openalex.org/W4808770"],"abstract_inverted_index":{"Elevated":[0],"plasma":[1,36],"concentrations":[2,133,146],"of":[3,31,62,66,90,100,116,137,197],"homocysteine,":[4],"a":[5,10,40,181],"sulfur-containing":[6],"amino":[7],"acid,":[8,118],"are":[9,86,95,147,152],"risk":[11],"factor":[12],"for":[13,26,88,214],"coronary,":[14],"cerebral":[15],"and":[16,70,92,121,140,203],"peripheral":[17],"artery":[18],"disease.":[19],"Next":[20],"to":[21,54,123,154,168],"other":[22],"factors,":[23],"drugs":[24,69,161,213],"used":[25,87],"the":[27,47,56,60,77,81,114,144,198],"prevention":[28],"or":[29],"treatment":[30,89,178,186],"cardiovascular":[32],"disease":[33],"may":[34,45,222],"modulate":[35],"homocysteine":[37,43,74,101,132,145,169,172,199],"levels.":[38],"Thus,":[39],"drug":[41],"induced":[42],"increase":[44,99,105,173],"counteract":[46],"desired":[48],"cardioprotective":[49],"effect.":[50],"The":[51,135,194],"aim":[52],"is":[53,205],"summarize":[55],"current":[57],"knowledge":[58],"on":[59,73,143,158],"effect":[61,191],"two":[63],"important":[64],"classes":[65],"drugs,":[67,72,79],"lipid-lowering":[68,78],"anti-hypertensive":[71],"metabolism.":[75,170],"Among":[76],"especially":[80],"fibric":[82],"acid":[83,139],"derivatives,":[84],"which":[85],"hypertriglyceridemia":[91],"low":[93],"HDL-cholesterol,":[94],"associated":[96],"with":[97,166,179,187,192],"an":[98],"by":[102,113,201],"20%-50%.":[103],"This":[104],"can":[106],"be":[107,223],"reduced,":[108],"but":[109,189],"not":[110,130,206],"totally":[111],"avoided":[112],"addition":[115],"folic":[117],"vitamin":[119],"B12":[120],"B6":[122],"fibrates.":[124],"HMG-CoA":[125],"reductase":[126],"inhibitors":[127],"(statins)":[128],"do":[129],"influence":[131,157],"substantially.":[134],"effects":[136],"nicotinic":[138],"n3-fatty":[141],"acids":[142],"less":[148],"clear,":[149],"more":[150],"studies":[151],"necessary":[153],"clarify":[155],"their":[156],"homocysteine.":[159],"Antihypertensive":[160],"have":[162],"also":[163],"been":[164,175],"studied":[165],"respect":[167],"A":[171],"has":[174],"shown":[176],"after":[177,185],"hydrochlorothiazide,":[180],"lowering":[182],"was":[183],"observed":[184],"beta-blockers,":[188],"no":[190],"ACE-inhibitors.":[193],"clinical":[195],"significance":[196],"elevation":[200],"fibrates":[202],"thiazides":[204],"clear.":[207],"However,":[208],"individual":[209],"patients":[210],"use":[211],"these":[212],"long":[215],"time,":[216],"indicating":[217],"that":[218],"even":[219],"moderate":[220],"increases":[221],"important.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}