{"id":"https://openalex.org/W1484345752","doi":"https://doi.org/10.4049/jimmunol.129.5.1936","title":"The relationship between human helper and suppressor factors to a streptococcal protein antigen.","display_name":"The relationship between human helper and suppressor factors to a streptococcal protein antigen.","publication_year":1982,"publication_date":"1982-11-01","ids":{"openalex":"https://openalex.org/W1484345752","doi":"https://doi.org/10.4049/jimmunol.129.5.1936","mag":"1484345752","pmid":"https://pubmed.ncbi.nlm.nih.gov/6214582"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.129.5.1936","doi":"https://doi.org/10.4049/jimmunol.129.5.1936","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.129.5.1936","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001465616","display_name":"T Lehner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"T Lehner","raw_affiliation_strings":["Department of Oral Immunology and Microbiology, Medical and Dental Schools, Guy\u2019s Hospital , London SE1 9RT ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Immunology and Microbiology, Medical and Dental Schools, Guy\u2019s Hospital , London SE1 9RT ,","institution_ids":["https://openalex.org/I1298207432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001465616"],"corresponding_institution_ids":["https://openalex.org/I1298207432"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.4033,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.94914973,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"129","issue":"5","first_page":"1936","last_page":"1940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/streptococcus-mutans","display_name":"Streptococcus mutans","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hla-dr6","display_name":"HLA-DRw6","score":0.906000018119812},{"id":"https://openalex.org/keywords/hla-dr4","display_name":"HLA-DR4","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6420000195503235},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.4909999966621399},{"id":"https://openalex.org/keywords/tolerance-zone","display_name":"tolerance zone","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6312351822853088},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5695276856422424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5160829424858093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37504905462265015},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3596417307853699},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10796031355857849},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06322446465492249}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013491","descriptor_name":"Suppressor Factors, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015804","descriptor_name":"HLA-DR4 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.129.5.1936","doi":"https://doi.org/10.4049/jimmunol.129.5.1936","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.129.5.1936","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:6214582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6214582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2016351495","https://openalex.org/W2011041363","https://openalex.org/W2413897994","https://openalex.org/W1536750390","https://openalex.org/W1542651967","https://openalex.org/W1910227938","https://openalex.org/W1809240669","https://openalex.org/W2412293384","https://openalex.org/W2071498387","https://openalex.org/W2000233410"],"abstract_inverted_index":{"Abstract":[0],"Helper":[1],"and":[2,70,112,140,145,160,165,181,234,288,308,324],"suppressor":[3,49,54,116,161,219,259,263,267,289,309,325],"functions":[4,326],"were":[5,56,73],"studied":[6],"in":[7,9,44,58,86,195,258,276,304,329,336],"parallel":[8],"human":[10,286],"lymphocytes":[11,152,306,310],"to":[12,26,38,78,84,122,135,205,255,296],"a":[13,61,119,199,297,312],"protein":[14],"antigen":[15,68],"isolated":[16,285],"from":[17],"Streptococcus":[18],"mutans.":[19],"Because":[20],"all":[21],"subjects":[22],"examined":[23],"have":[24,42,311],"antibodies":[25],"this":[27],"common":[28],"oral":[29],"microorganism,":[30],"the":[31,66,71,102,107,209,228,246,270,334],"hypothesis":[32],"was":[33,104,131,221],"tested":[34],"that":[35,126,177,238,283],"natural":[36],"sensitization":[37],"S.":[39],"mutans":[40],"might":[41],"induced":[43],"vivo":[45],"specific":[46,322],"helper":[47,52,108,123,154,196,217,239,243,277,287,307,323],"and/or":[48],"cells.":[50,92],"Specific":[51],"or":[53,80,218,231],"factors":[55,72],"released":[57,153],"vitro":[59],"with":[60,89,127,133,142,156,163,184,227,333],"range":[62,201,249,273,299],"of":[63,65,97,101,110,138,148,168,174,188,202,214,216,250,252,274,294,300,302,321],"doses":[64,167,251,301],"streptococcal":[67],"(SA)":[69],"assayed":[74],"for":[75,179],"their":[76],"ability":[77],"enhance":[79],"suppress":[81],"antibody-forming":[82],"cells":[83,220,240,264,290],"DNP-SA":[85],"cooperative":[87],"cultures":[88],"mouse":[90],"spleen":[91],"A":[93],"differential":[94],"dose":[95,193,272],"response":[96],"predominantly":[98],"1000":[99,157,191],"ng":[100,137,147,158,192],"SA":[103,139,159,253,275],"found":[105],"between":[106],"function":[109,315],"HLA-DRw6":[111],"DR4":[113,151],"lymphocytes.":[114],"The":[115,170,190,212,280,319],"activity":[117,155,162],"showed":[118],"reciprocal":[120,313],"relationship":[121],"activity,":[124,197],"so":[125],"DRw6":[128],"lymphocytes,":[129],"help":[130],"elicited":[132],"1":[134],"10":[136],"suppression":[141],"100,":[143],"1000,":[144],"10,000":[146,256],"SA;":[149],"however,":[150],"lower":[164],"higher":[166],"SA.":[169],"resulting":[171],"dose-response":[172],"pattern":[173],"suppression-help-suppression":[175],"resembled":[176],"recorded":[178],"low-zone":[180],"high-zone":[182],"tolerance":[183],"an":[185],"intermediate":[186],"zone":[187],"immunity.":[189],"shift":[194],"within":[198],"broad":[200,298],"suppression,":[203],"seems":[204],"be":[206],"dependent":[207],"on":[208,316],"HLA-DR":[210],"locus.":[211],"effect":[213],"depletion":[215],"then":[222],"investigated":[223],"by":[224],"killing":[225],"these":[226],"monoclonal":[229],"T4":[230],"T8":[232],"antisera":[233],"complement.":[235],"This":[236],"revealed":[237],"will":[241,265],"release":[242,266],"factor":[244,268],"over":[245,269],"entire":[247,271],"test":[248],"(1":[254],"ng)":[257],"cell-depleted":[260,278],"cultures.":[261,279],"Conversely,":[262],"results":[281],"suggest":[282],"although":[284],"are":[291],"each":[292],"capable":[293],"responding":[295],"SA,":[303],"unseparated":[305],"controlling":[314],"antibody":[317],"formation.":[318],"coexistence":[320],"demonstrated":[327],"here":[328],"man":[330],"is":[331],"consistent":[332],"findings":[335],"mice.":[337]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}