{"id":"https://openalex.org/W148406515","doi":"https://doi.org/10.4049/jimmunol.184.supp.51.4","title":"A naturally antagonist of human IL-23 inhibits the development and function of human Th17 cells (51.4)","display_name":"A naturally antagonist of human IL-23 inhibits the development and function of human Th17 cells (51.4)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W148406515","doi":"https://doi.org/10.4049/jimmunol.184.supp.51.4","mag":"148406515"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.51.4","doi":"https://doi.org/10.4049/jimmunol.184.supp.51.4","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.51.4","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108202677","display_name":"Grant E. Gallagher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grant Gallagher","raw_affiliation_strings":["HUMIGEN LLC, the Institute for Genetic Immunology , Hamilton, NJ","1HUMIGEN LLC, the Institute for Genetic Immunology, Hamilton, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HUMIGEN LLC, the Institute for Genetic Immunology , Hamilton, NJ","institution_ids":[]},{"raw_affiliation_string":"1HUMIGEN LLC, the Institute for Genetic Immunology, Hamilton, NJ","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109951660","display_name":"Raymond Y.-L. Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond Yu","raw_affiliation_strings":["HUMIGEN LLC, the Institute for Genetic Immunology , Hamilton, NJ","1HUMIGEN LLC, the Institute for Genetic Immunology, Hamilton, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HUMIGEN LLC, the Institute for Genetic Immunology , Hamilton, NJ","institution_ids":[]},{"raw_affiliation_string":"1HUMIGEN LLC, the Institute for Genetic Immunology, Hamilton, NJ","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"51.4","last_page":"51.4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9860000014305115},{"id":"https://openalex.org/keywords/il-17f","display_name":"IL-17F","score":1.0},{"id":"https://openalex.org/keywords/rorgammat","display_name":"ROR\u03b3t","score":0.7770000100135803},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.44200000166893005},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.6830000281333923},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C74737994","wikidata":"https://www.wikidata.org/wiki/Q18031207","display_name":"RAR-related orphan receptor gamma","level":4,"score":0.7727459669113159},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.568855345249176},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.5656033754348755},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5025060176849365},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.49814558029174805},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4860580265522003},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.43123704195022583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4277493953704834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3529295325279236},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33614951372146606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2408924698829651},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22815215587615967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09373953938484192},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.51.4","doi":"https://doi.org/10.4049/jimmunol.184.supp.51.4","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.51.4","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2128377184","https://openalex.org/W2002542843","https://openalex.org/W1998895238","https://openalex.org/W7097116931","https://openalex.org/W2157321902","https://openalex.org/W4295077775","https://openalex.org/W2112074373","https://openalex.org/W83740233","https://openalex.org/W2186979013","https://openalex.org/W2187634724"],"abstract_inverted_index":{"Abstract":[0],"The":[1,31,139],"Th17":[2,15,35,64,71,137,180,214,229],"subset":[3],"of":[4,12,33,43,51,70,118,129,156,169,190,208,213,223],"CD4":[5],"cells":[6,16,36,72,181],"is":[7,56,61,141,204],"critical":[8],"to":[9,63,108,177,227],"inflammation.":[10],"Secretion":[11],"IL-17":[13],"by":[14,58,76,172],"drives":[17],"inflammation":[18],"in":[19,40,148,163,182],"human":[20,179],"diseases":[21],"and":[22,29,46,48,66,136,143,165,195,210],"their":[23,54],"mouse":[24],"models,":[25],"including":[26,193],"IBD,":[27],"psoriasis":[28],"arthritis.":[30],"differentiation":[32,85],"mature":[34],"depends":[37],"upon":[38],"stimulation":[39],"the":[41,49,114,119,130,149,167,184,188],"presence":[42],"IL-6,":[44],"TGF-\u03b2":[45],"IL-21":[47],"induction":[50,69],"ROR\u03b3t,":[52],"but":[53,80],"phenotype":[55],"stabilised":[57],"IL-23,":[59],"which":[60,83],"essential":[62],"stability":[65],"function.":[67],"Initial":[68],"can":[73,86],"be":[74,87],"antagonised":[75],"IL-4":[77],"or":[78],"IFN-\u03b3,":[79],"mechanisms":[81],"through":[82],"terminal":[84],"inhibited":[88],"have":[89],"not":[90,199],"been":[91],"identified.":[92],"We":[93],"found":[94],"that":[95,101,125,219],"HuIL23R\u03b1":[96,131,157,224],"chain":[97,132,158],"mRNA":[98],"transcripts":[99],"exist":[100],"lack":[102],"exon-9":[103],"(\u201c\u03949\u201d);":[104],"these":[105],"are":[106],"translated":[107],"a":[109,205,211],"truncated":[110],"receptor":[111],"form":[112,153,186,222],"containing":[113],"entire":[115],"external":[116],"domain":[117],"wild-type":[120],"protein.":[121],"Here,":[122],"we":[123],"show":[124],"this":[126,220],"soluble":[127,152,221],"variant":[128,140],"antagonises":[133],"IL-23":[134,162,209],"signalling":[135],"maturation.":[138],"secreted":[142],"present":[144],"at":[145],"low":[146],"levels":[147],"blood.":[150],"This":[151],"represents":[154],"10%":[155],"mRNA.":[159],"It":[160],"binds":[161],"solution":[164],"inhibits":[166,187],"phosphorylation":[168],"STAT3":[170],"caused":[171],"IL-23.":[173],"In":[174],"experiments":[175],"designed":[176],"differentiate":[178],"vitro,":[183],"\u03949":[185,197],"production":[189],"Th17-associated":[191],"cytokines,":[192],"IL-17A":[194],"IL-17F.":[196],"does":[198],"bind":[200],"IL-12;":[201],"thus":[202],"it":[203],"specific":[206],"inhibitor":[207],"modulator":[212],"cells.":[215],"Our":[216],"results":[217],"indicate":[218],"likely":[225],"functions":[226],"regulate":[228],"activity.":[230]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2016-06-24T00:00:00"}