{"id":"https://openalex.org/W1483942483","doi":null,"title":"MiR-126 regulated breast cancer cell invasion by targeting ADAM9.","display_name":"MiR-126 regulated breast cancer cell invasion by targeting ADAM9.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1483942483","mag":"1483942483","pmid":"https://pubmed.ncbi.nlm.nih.gov/26261534","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525868"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3508586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525868","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525868","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064256821","display_name":"Chengzheng Wang","orcid":"https://orcid.org/0009-0002-9374-4270","observed_orcids":["https://orcid.org/0009-0002-9374-4270"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-Zheng Wang","raw_affiliation_strings":["Department of Breast Surgery, The Affiliated Tumor Hospital of Zhengzhou University Zhengzhou 450008, Henan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Affiliated Tumor Hospital of Zhengzhou University Zhengzhou 450008, Henan, P.R. China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Yuan","raw_affiliation_strings":["Department of Breast Surgery, The Affiliated Tumor Hospital of Zhengzhou University Zhengzhou 450008, Henan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Affiliated Tumor Hospital of Zhengzhou University Zhengzhou 450008, Henan, P.R. China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100451108","display_name":"Yin Li","orcid":"https://orcid.org/0000-0001-8741-107X","observed_orcids":["https://orcid.org/0000-0001-8741-107X"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Li","raw_affiliation_strings":["Department of Thoracic Surgery, The Affiliated Tumor Hospital of Zhengzhou University Zhengzhou 450008, Henan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The Affiliated Tumor Hospital of Zhengzhou University Zhengzhou 450008, Henan, P.R. China","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I38877650"],"apc_list":null,"apc_paid":null,"fwci":2.3827,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.88599022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"6","first_page":"6547","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-126","display_name":"miR-126","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adam9","display_name":"ADAM9","score":0.8220000267028809},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7319999933242798},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8629999756813049},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7528820037841797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6990638375282288},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6808841824531555},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6234682202339172},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5984987616539001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5912845134735107},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5816558599472046},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.573035717010498},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4660322070121765},{"id":"https://openalex.org/C11957725","wikidata":"https://www.wikidata.org/wiki/Q5533590","display_name":"Gentamicin protection assay","level":4,"score":0.4227294325828552},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4165574312210083},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4150035083293915},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.4126783013343811},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3627690076828003},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.1328027844429016},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.129752516746521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08828318119049072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3508586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525868","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4525868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525868","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:26261534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26261534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:1483942483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26261534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3508586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525868","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1536340771","https://openalex.org/W1905458625","https://openalex.org/W1936021384","https://openalex.org/W1963835526","https://openalex.org/W1965371218","https://openalex.org/W1974578652","https://openalex.org/W1978025728","https://openalex.org/W1981994655","https://openalex.org/W1982092344","https://openalex.org/W1983555204","https://openalex.org/W1990426115","https://openalex.org/W1993879156","https://openalex.org/W1997890663","https://openalex.org/W2000304809","https://openalex.org/W2020500674","https://openalex.org/W2020830322","https://openalex.org/W2021358082","https://openalex.org/W2046645061","https://openalex.org/W2057022091","https://openalex.org/W2066288043","https://openalex.org/W2067393348","https://openalex.org/W2091466847","https://openalex.org/W2103615226","https://openalex.org/W2118611567","https://openalex.org/W2121220324","https://openalex.org/W2129475502","https://openalex.org/W2144821627","https://openalex.org/W2146157095","https://openalex.org/W2153661308","https://openalex.org/W2161817637","https://openalex.org/W2485983537","https://openalex.org/W4250152278"],"related_works":["https://openalex.org/W3096662645","https://openalex.org/W2799625384","https://openalex.org/W1965371218","https://openalex.org/W2167442006","https://openalex.org/W1587529537","https://openalex.org/W2074532257","https://openalex.org/W2580307452","https://openalex.org/W2758639219","https://openalex.org/W7149034519","https://openalex.org/W2239832283"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"has":[2],"shown":[3],"that":[4,22,97,153],"microRNAs":[5],"(miRNAs)":[6],"deregulation":[7],"is":[8],"commonly":[9],"observed":[10],"in":[11,28,49,103,131,169],"human":[12,29,73],"malignancies":[13],"and":[14,41],"crucial":[15],"to":[16,63],"cancer":[17,31,54,75,105,128,146,171],"metastasis.":[18],"Herein,":[19],"we":[20],"demonstrated":[21],"miR-126":[23,68,81,98,115,154],"play":[24],"a":[25,39,158],"suppressor":[26,160],"role":[27],"breast":[30,53,74,104,127,145,170],"cells":[32],"invasion":[33,71,130,165],"through":[34],"the":[35,65,70,119],"direct":[36],"repression":[37],"of":[38,52,67,72,80,114,122,135,163],"disintegrin":[40],"metalloprotease":[42],"9":[43],"(ADAM9).":[44],"MiR-126":[45],"expression":[46,99],"was":[47,61,87,100],"investigated":[48],"forty":[50],"cases":[51],"specimens":[55,106],"by":[56,90,137,166],"real-time":[57],"PCR.":[58],"Transwell":[59],"assay":[60],"conducted":[62],"explore":[64],"effects":[66],"on":[69,83],"cell":[76,129,147,164],"lines.":[77],"The":[78],"impact":[79],"overexpression":[82],"putative":[84],"target":[85],"ADAM9":[86,136,168],"subsequently":[88],"confirmed":[89],"Western":[91],"blot":[92],"analysis.":[93],"Our":[94],"results":[95],"indicated":[96],"frequently":[101],"down-regulated":[102],"compared":[107],"with":[108],"adjacent":[109],"normal":[110],"tissues":[111],"(P<0.05).":[112],"Overexpression":[113],"significantly":[116],"reduced":[117],"(P<0.05)":[118,126,144],"protein":[120],"levels":[121],"ADAM9,":[123],"further":[124],"suppressed":[125],"vitro.":[132],"Meanwhile,":[133],"knockdown":[134],"small":[138],"interfering":[139],"RNA":[140],"(siRNA)":[141],"also":[142],"inhibited":[143],"invasion.":[148],"Thus,":[149],"our":[150],"study":[151],"revealed":[152],"may":[155],"act":[156],"as":[157],"tumor":[159],"via":[161],"inhibition":[162],"downregulating":[167],"development.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
