{"id":"https://openalex.org/W1483674093","doi":"https://doi.org/10.1002/ijc.28020","title":"Human liver carboxylesterase 1 outperforms alpha\u2010fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients","display_name":"Human liver carboxylesterase 1 outperforms alpha\u2010fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients","publication_year":2013,"publication_date":"2013-01-15","ids":{"openalex":"https://openalex.org/W1483674093","doi":"https://doi.org/10.1002/ijc.28020","mag":"1483674093","pmid":"https://pubmed.ncbi.nlm.nih.gov/23319432"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.28020","doi":"https://doi.org/10.1002/ijc.28020","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.28020","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://onlinelibrary.wiley.com/doi/10.1002/ijc.28020/abstract","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016385180","display_name":"Keun Na","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210162080","display_name":"Yonsei Proteome Research Center","ror":"https://ror.org/055yqn475","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210162080"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Keun Na","raw_affiliation_strings":["Graduate Program in Functional Genomics, Yonsei University, Seoul, Korea","Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Functional Genomics, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210162080"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Seul\u2010Ki Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210162080","display_name":"Yonsei Proteome Research Center","ror":"https://ror.org/055yqn475","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210162080"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seul\u2010Ki Jeong","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea","Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210162080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768168","display_name":"Min Jung Lee","orcid":"https://orcid.org/0000-0001-8293-3418","observed_orcids":["https://orcid.org/0000-0001-8293-3418"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210162080","display_name":"Yonsei Proteome Research Center","ror":"https://ror.org/055yqn475","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210162080"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Jung Lee","raw_affiliation_strings":["Department of Pathology Yonsei University College of Medicine Seoul Korea","Integrated OMICS for Biomedical Science, World Class University Program, Yonsei University, Seoul, Korea","Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Yonsei University College of Medicine Seoul Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Integrated OMICS for Biomedical Science, World Class University Program, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210162080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070318085","display_name":"Sang Yun Cho","orcid":"https://orcid.org/0000-0002-6593-1960","observed_orcids":["https://orcid.org/0000-0002-6593-1960"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210162080","display_name":"Yonsei Proteome Research Center","ror":"https://ror.org/055yqn475","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210162080"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Yun Cho","raw_affiliation_strings":["Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210162080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608915","display_name":"Sun A Kim","orcid":"https://orcid.org/0000-0002-0891-2093","observed_orcids":["https://orcid.org/0000-0002-0891-2093"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun A Kim","raw_affiliation_strings":["Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043253434","display_name":"Min\u2010Ji Lee","orcid":"https://orcid.org/0009-0007-6555-1232","observed_orcids":["https://orcid.org/0009-0007-6555-1232"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210162080","display_name":"Yonsei Proteome Research Center","ror":"https://ror.org/055yqn475","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210162080"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min\u2010Ji Lee","raw_affiliation_strings":["Department of Pathology, Yonsei University College of Medicine, Seoul, Korea","Integrated OMICS for Biomedical Science World Class University Program Yonsei University Seoul Korea","Yonsei Proteome Reasearch Center Yonsei University Seoul Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Integrated OMICS for Biomedical Science World Class University Program Yonsei University Seoul Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Yonsei Proteome Reasearch Center Yonsei University Seoul Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210162080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035695627","display_name":"Si Young Song","orcid":"https://orcid.org/0000-0002-1417-4314","observed_orcids":["https://orcid.org/0000-0002-1417-4314"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Si Young Song","raw_affiliation_strings":["Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115588094","display_name":"Hoguen Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hoguen Kim","raw_affiliation_strings":["Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100682102","display_name":"Kyung Sik Kim","orcid":"https://orcid.org/0000-0001-9498-284X","observed_orcids":["https://orcid.org/0000-0001-9498-284X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung Sik Kim","raw_affiliation_strings":["Department of Surgery, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089995283","display_name":"Hyun Woong Lee","orcid":"https://orcid.org/0000-0002-6958-3035","observed_orcids":["https://orcid.org/0000-0002-6958-3035"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Woong Lee","raw_affiliation_strings":["Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006448477","display_name":"Young\u2010Ki Paik","orcid":"https://orcid.org/0000-0002-8146-1751","observed_orcids":["https://orcid.org/0000-0002-8146-1751"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210162080","display_name":"Yonsei Proteome Research Center","ror":"https://ror.org/055yqn475","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210162080"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young\u2010Ki Paik","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea","Graduate Program in Functional Genomics, Yonsei University, Seoul, Korea","Integrated OMICS for Biomedical Science, World Class University Program, Yonsei University, Seoul, Korea","Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Graduate Program in Functional Genomics, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Integrated OMICS for Biomedical Science, World Class University Program, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210162080"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006448477"],"corresponding_institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210162080"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.8236,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.84172738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"133","issue":"2","first_page":"408","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8619999885559082},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9860000014305115},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.7900000214576721},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.6029999852180481},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/antibody-based-assays","display_name":"antibody-based assays","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.8240000009536743},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/korean-patients","display_name":"Korean patients","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8636350631713867},{"id":"https://openalex.org/C2778325069","wikidata":"https://www.wikidata.org/wiki/Q409840","display_name":"Carboxylesterase","level":3,"score":0.8097243309020996},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.6320220232009888},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6185911893844604},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.569699764251709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4431031048297882},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43341487646102905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3901635706424713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.364513099193573},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3524388074874878},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34997695684432983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3461610972881317},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14119625091552734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0851936936378479},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ijc.28020","doi":"https://doi.org/10.1002/ijc.28020","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.28020","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:23319432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23319432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/87094","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/87094","pdf_url":"http://onlinelibrary.wiley.com/doi/10.1002/ijc.28020/abstract","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/87094","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/87094","pdf_url":"http://onlinelibrary.wiley.com/doi/10.1002/ijc.28020/abstract","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1483674093.pdf","grobid_xml":"https://content.openalex.org/works/W1483674093.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W23602240","https://openalex.org/W1507270361","https://openalex.org/W1555041877","https://openalex.org/W1691930647","https://openalex.org/W1971189741","https://openalex.org/W1977773425","https://openalex.org/W1983521336","https://openalex.org/W1994657678","https://openalex.org/W1997429952","https://openalex.org/W1999318971","https://openalex.org/W2008523252","https://openalex.org/W2008615142","https://openalex.org/W2009378591","https://openalex.org/W2017810273","https://openalex.org/W2019109364","https://openalex.org/W2020215421","https://openalex.org/W2026866220","https://openalex.org/W2033660869","https://openalex.org/W2047165004","https://openalex.org/W2051224445","https://openalex.org/W2051501152","https://openalex.org/W2052644289","https://openalex.org/W2057011766","https://openalex.org/W2061542009","https://openalex.org/W2070778756","https://openalex.org/W2074849180","https://openalex.org/W2086720898","https://openalex.org/W2089529741","https://openalex.org/W2106787323","https://openalex.org/W2122773923","https://openalex.org/W2132834456","https://openalex.org/W2140830323","https://openalex.org/W2152575748","https://openalex.org/W2158215714","https://openalex.org/W2159183335","https://openalex.org/W2163403599","https://openalex.org/W2170054023","https://openalex.org/W3023828467","https://openalex.org/W3149449331"],"related_works":["https://openalex.org/W2150113937","https://openalex.org/W4242682009","https://openalex.org/W2291023880","https://openalex.org/W2004554617","https://openalex.org/W2824088326","https://openalex.org/W2892524678","https://openalex.org/W4380667531","https://openalex.org/W2069978508","https://openalex.org/W2098171893","https://openalex.org/W2041712723"],"abstract_inverted_index":{"Although":[0],"alpha-fetoprotein":[1],"(AFP)":[2],"is":[3,38,168,226],"currently":[4],"the":[5,72,75,127,140,147,187,206,237],"major":[6],"serologic":[7],"biomarker":[8,235],"for":[9,54,197,216],"hepatocellular":[10],"carcinoma":[11],"(HCC),":[12],"it":[13],"cannot":[14],"efficiently":[15],"distinguish":[16],"this":[17,36,232],"cancer":[18,101,105,179],"from":[19,86,180,219],"other":[20,128,220],"forms":[21,221],"of":[22,35,44,115,142,158,189,222],"liver":[23,92,145,181,223],"disease":[24],"in":[25,84,120,177,183,202,236],"early":[26,203],"diagnosis":[27],"due":[28],"to":[29,39,60,66,211,229],"its":[30],"low":[31],"sensitivity.":[32],"The":[33,113],"aim":[34],"study":[37],"compare":[40],"sensitivity":[41,199],"and":[42,49,56,71,103,126,136,155,160,174,191,200],"specificity":[43,201],"human":[45],"carboxylesterase":[46],"1":[47],"(hCE1)":[48,154],"AFP":[50,57,159,192],"biomarker.":[51],"Antibody-based":[52],"assays":[53],"hCE1":[55,116,167,190,208],"were":[58,117,150],"used":[59],"test":[61],"both":[62],"biomarkers":[63],"with":[64,89,108,122],"respect":[65],"diagnostic":[67,214],"efficiency,":[68],"Youden's":[69,137],"index":[70],"area":[73],"under":[74],"curve":[76],"(AUC)":[77],"through":[78],"receiver":[79],"operating":[80],"characteristic":[81],"(ROC)":[82],"analysis":[83],"plasma":[85],"208":[87],"patients":[88,121],"HCC":[90,123,143,218],"(n=57),":[91],"cirrhosis":[93,146],"(n=27),":[94],"chronic":[95],"hepatitis":[96],"(n=37),":[97],"cholangiocarcinoma":[98],"(n=22),":[99],"gastric":[100],"(n=31)":[102],"pancreatic":[104],"(n=34),":[106],"along":[107],"52":[109],"healthy":[110],"donors":[111],"(HDs).":[112],"levels":[114],"significantly":[118],"higher":[119],"than":[124],"HDs":[125],"diseases":[129],"(p<0.005),":[130],"further":[131,230],"verified":[132],"by":[133],"AUC":[134,148],"values":[135,149],"index.":[138],"In":[139],"set":[141],"versus":[144],"0.744":[151],"(AFP),":[152],"0.918":[153],"0.938":[156],"(combination":[157],"hCE1),":[161],"respectively.":[162],"These":[163],"results":[164],"indicate":[165],"that":[166],"not":[169],"only":[170],"a":[171],"more":[172],"potent":[173],"specific":[175],"marker":[176],"distinguishing":[178],"diseases,":[182],"particular":[184],"cirrhosis,":[185],"but":[186],"combination":[188],"shows":[193],"also":[194],"synergistic":[195],"potential":[196],"greater":[198],"diagnosis.":[204],"Therefore":[205],"antibody-based":[207],"assay":[209],"appears":[210],"have":[212],"high":[213],"efficiency":[215],"discriminating":[217],"disease.":[224],"It":[225],"now":[227],"feasible":[228],"validate":[231],"novel":[233],"plasma-based":[234],"large":[238],"cohort":[239],"we":[240],"assembled.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}