{"id":"https://openalex.org/W148352488","doi":null,"title":"The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.","display_name":"The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W148352488","mag":"148352488","pmid":"https://pubmed.ncbi.nlm.nih.gov/22252577"},"language":"en","primary_location":{"id":"pmid:22252577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22252577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038787808","display_name":"Srinath Sundararajan","orcid":"https://orcid.org/0000-0002-1339-7866","observed_orcids":["https://orcid.org/0000-0002-1339-7866"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinath Sundararajan","raw_affiliation_strings":["Department of Internal Medicine, University of Nevada School of Medicine, Las Vegas, Nevada 89135, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Nevada School of Medicine, Las Vegas, Nevada 89135, USA","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089181966","display_name":"Aisha K. Ahmed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aisha Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103535184","display_name":"Oscar B. Goodman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oscar B Goodman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0993,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.75211237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"10","first_page":"748","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7990000247955322},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hereditary-breast-and-ovarian-cancer-syndrome","display_name":"hereditary breast and ovarian cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.6690000295639038},{"id":"https://openalex.org/keywords/prostate-cancer-pathogenesis","display_name":"prostate cancer pathogenesis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/prostate-cancer-treatment","display_name":"prostate cancer treatment","score":0.7689999938011169},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8013235926628113},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7275246381759644},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.6564724445343018},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.652636706829071},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5755738019943237},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5594872236251831},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.55136638879776},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5247706770896912},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.522959291934967},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.509743869304657},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4976678192615509},{"id":"https://openalex.org/C2909462720","wikidata":"https://www.wikidata.org/wiki/Q421651","display_name":"BRCA2 Protein","level":5,"score":0.49596819281578064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4918665885925293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3815534710884094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3688891530036926},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3632867932319641},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3480643033981323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25330957770347595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1617736518383026}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22252577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22252577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},{"id":"mag:148352488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22252577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W16746045","https://openalex.org/W121553317","https://openalex.org/W1571891420","https://openalex.org/W1752089945","https://openalex.org/W1876809419","https://openalex.org/W1901381303","https://openalex.org/W1968469516","https://openalex.org/W1969603568","https://openalex.org/W1971322560","https://openalex.org/W1971781813","https://openalex.org/W1972710550","https://openalex.org/W1972769310","https://openalex.org/W1973690102","https://openalex.org/W1975823330","https://openalex.org/W1977546001","https://openalex.org/W1979256255","https://openalex.org/W1984792589","https://openalex.org/W1987562801","https://openalex.org/W1992101827","https://openalex.org/W1995254238","https://openalex.org/W1995404520","https://openalex.org/W1996716229","https://openalex.org/W1998452180","https://openalex.org/W2002555966","https://openalex.org/W2007686629","https://openalex.org/W2008046181","https://openalex.org/W2009454156","https://openalex.org/W2009759387","https://openalex.org/W2014140511","https://openalex.org/W2015637732","https://openalex.org/W2018299474","https://openalex.org/W2018825948","https://openalex.org/W2020636054","https://openalex.org/W2021343970","https://openalex.org/W2025015409","https://openalex.org/W2025370752","https://openalex.org/W2026076019","https://openalex.org/W2030875435","https://openalex.org/W2032907237","https://openalex.org/W2037191150","https://openalex.org/W2039211343","https://openalex.org/W2044713924","https://openalex.org/W2047200356","https://openalex.org/W2051409228","https://openalex.org/W2051651668","https://openalex.org/W2053003311","https://openalex.org/W2056589762","https://openalex.org/W2058025514","https://openalex.org/W2059365987","https://openalex.org/W2061151099","https://openalex.org/W2068176376","https://openalex.org/W2068377750","https://openalex.org/W2076860818","https://openalex.org/W2079659589","https://openalex.org/W2081027578","https://openalex.org/W2082825443","https://openalex.org/W2084491471","https://openalex.org/W2086570104","https://openalex.org/W2098054190","https://openalex.org/W2103533058","https://openalex.org/W2107482866","https://openalex.org/W2109173575","https://openalex.org/W2109465247","https://openalex.org/W2110017381","https://openalex.org/W2111659024","https://openalex.org/W2117503386","https://openalex.org/W2118035762","https://openalex.org/W2121769309","https://openalex.org/W2128168784","https://openalex.org/W2128325937","https://openalex.org/W2130414070","https://openalex.org/W2134536765","https://openalex.org/W2136111611","https://openalex.org/W2138785710","https://openalex.org/W2145847071","https://openalex.org/W2147126714","https://openalex.org/W2148263950","https://openalex.org/W2148983297","https://openalex.org/W2149122422","https://openalex.org/W2156003892","https://openalex.org/W2156642861","https://openalex.org/W2158734599","https://openalex.org/W2160475700","https://openalex.org/W2165170481","https://openalex.org/W2168225429","https://openalex.org/W2168809955","https://openalex.org/W2169443052","https://openalex.org/W2171667490","https://openalex.org/W2171972386","https://openalex.org/W2328105863","https://openalex.org/W2432429035","https://openalex.org/W2438300343","https://openalex.org/W2593526662","https://openalex.org/W2772971838"],"related_works":["https://openalex.org/W4376459526","https://openalex.org/W3165176221","https://openalex.org/W2772419959","https://openalex.org/W4388341131","https://openalex.org/W2133161195","https://openalex.org/W2034024919","https://openalex.org/W3126639524","https://openalex.org/W4366833142","https://openalex.org/W4211216638","https://openalex.org/W4310975164"],"abstract_inverted_index":{"The":[0],"breast":[1],"cancer":[2,38],"susceptibility":[3],"genes":[4,61],"1":[5],"(BRCA1)":[6],"and":[7,26,65,79],"2":[8],"(BRCA2)":[9],"are":[10,18,43],"cellular":[11],"proteins":[12],"involved":[13],"in":[14,21,62],"DNA":[15],"repair.":[16],"They":[17],"normally":[19],"expressed":[20],"the":[22,33,57,63,74,80],"breast,":[23],"ovaries,":[24],"prostate,":[25],"other":[27,47],"tissues.":[28],"Their":[29],"germline":[30,85],"mutation":[31,41],"is":[32],"cause":[34],"of":[35,59,68,77,83],"hereditary":[36],"breast-ovarian":[37],"syndromes.":[39],"BRCA":[40,60,84],"carriers":[42],"also":[44,72],"susceptible":[45],"to":[46],"cancers,":[48],"notably":[49],"prostate":[50,69],"cancer.":[51,70],"In":[52],"this":[53],"article,":[54],"we":[55],"review":[56],"role":[58],"pathogenesis":[64],"clinical":[66],"course":[67],"We":[71],"discuss":[73],"molecular":[75],"mechanisms":[76],"action":[78],"therapeutic":[81],"implications":[82],"mutations.":[86]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
