{"id":"https://openalex.org/W148349092","doi":null,"title":"Stem cell-based therapies for age-related macular degeneration: current status and prospects.","display_name":"Stem cell-based therapies for age-related macular degeneration: current status and prospects.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W148349092","mag":"148349092","pmid":"https://pubmed.ncbi.nlm.nih.gov/25550892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276150"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3243583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276150","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107933935","display_name":"Yalin Mu","orcid":"https://orcid.org/0009-0001-8494-306X","observed_orcids":["https://orcid.org/0009-0001-8494-306X"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalin Mu","raw_affiliation_strings":["Department of Ophthalmology, Yellow River Hospital, Henan University of Science and Technology Sanmenxia City, Henan Province, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yellow River Hospital, Henan University of Science and Technology Sanmenxia City, Henan Province, People's Republic of China","institution_ids":["https://openalex.org/I167383011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029211223","display_name":"Manli Zhao","orcid":"https://orcid.org/0000-0002-7864-3853","observed_orcids":["https://orcid.org/0000-0002-7864-3853"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manli Zhao","raw_affiliation_strings":["Department of Ophthalmology, Yellow River Hospital, Henan University of Science and Technology Sanmenxia City, Henan Province, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yellow River Hospital, Henan University of Science and Technology Sanmenxia City, Henan Province, People's Republic of China","institution_ids":["https://openalex.org/I167383011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071050960","display_name":"Guangming Su","orcid":"https://orcid.org/0000-0001-5774-3401","observed_orcids":["https://orcid.org/0000-0001-5774-3401"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangming Su","raw_affiliation_strings":["Department of Ophthalmology, Yellow River Hospital, Henan University of Science and Technology Sanmenxia City, Henan Province, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yellow River Hospital, Henan University of Science and Technology Sanmenxia City, Henan Province, People's Republic of China","institution_ids":["https://openalex.org/I167383011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I167383011"],"apc_list":null,"apc_paid":null,"fwci":4.315,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.93528597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"11","first_page":"3843","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.24040000140666962,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dry-age-related-macular-degeneration","display_name":"dry age-related macular degeneration","score":0.8529999852180481},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9490000009536743},{"id":"https://openalex.org/keywords/rpe-differentiation","display_name":"RPE differentiation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/subretinal-transplantation","display_name":"subretinal transplantation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/visual-recovery","display_name":"visual recovery","score":0.8389999866485596},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8374137878417969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8237403035163879},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7375048398971558},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6230760812759399},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6213948726654053},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.602067768573761},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.580635130405426},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5355446338653564},{"id":"https://openalex.org/C2991880128","wikidata":"https://www.wikidata.org/wiki/Q47200750","display_name":"Geographic atrophy","level":3,"score":0.5128408074378967},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5030471682548523},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.45586255192756653},{"id":"https://openalex.org/C2780929884","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Blindness","level":2,"score":0.4414482116699219},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3525744080543518},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3239997625350952},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3182264566421509},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.30148857831954956},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2353123426437378},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.1488012969493866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11377409100532532},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10395097732543945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3243583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4276150","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276150","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:25550892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25550892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:148349092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25550892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3243583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1480145962","https://openalex.org/W1482571356","https://openalex.org/W1487528435","https://openalex.org/W1522272765","https://openalex.org/W1966300591","https://openalex.org/W1966476278","https://openalex.org/W1974644062","https://openalex.org/W1983332870","https://openalex.org/W1988245456","https://openalex.org/W1988648222","https://openalex.org/W1994009311","https://openalex.org/W1999919809","https://openalex.org/W2002300485","https://openalex.org/W2002930046","https://openalex.org/W2006237657","https://openalex.org/W2008999158","https://openalex.org/W2013704845","https://openalex.org/W2013744830","https://openalex.org/W2014731453","https://openalex.org/W2014987484","https://openalex.org/W2016240894","https://openalex.org/W2016508121","https://openalex.org/W2028950558","https://openalex.org/W2029371198","https://openalex.org/W2031696533","https://openalex.org/W2033646700","https://openalex.org/W2038106981","https://openalex.org/W2045048112","https://openalex.org/W2048140742","https://openalex.org/W2058607314","https://openalex.org/W2061445084","https://openalex.org/W2068742492","https://openalex.org/W2074314696","https://openalex.org/W2074734341","https://openalex.org/W2075727700","https://openalex.org/W2076760704","https://openalex.org/W2077523602","https://openalex.org/W2077891356","https://openalex.org/W2087357183","https://openalex.org/W2088537391","https://openalex.org/W2090521908","https://openalex.org/W2091315047","https://openalex.org/W2091416645","https://openalex.org/W2092366894","https://openalex.org/W2092960067","https://openalex.org/W2101777616","https://openalex.org/W2105161755","https://openalex.org/W2109583860","https://openalex.org/W2114268866","https://openalex.org/W2125987139","https://openalex.org/W2143282938","https://openalex.org/W2145116545","https://openalex.org/W2146078700","https://openalex.org/W2149526310","https://openalex.org/W2149968101","https://openalex.org/W2152400142","https://openalex.org/W2153411657","https://openalex.org/W2156377891","https://openalex.org/W2161264600","https://openalex.org/W2162759106","https://openalex.org/W2165062842","https://openalex.org/W2167783060","https://openalex.org/W2314642451","https://openalex.org/W2409342531","https://openalex.org/W2993133819"],"related_works":["https://openalex.org/W4299355983","https://openalex.org/W4213455147","https://openalex.org/W2294783182","https://openalex.org/W3010405839","https://openalex.org/W2139710048","https://openalex.org/W804972530","https://openalex.org/W7166862716","https://openalex.org/W1984693518","https://openalex.org/W2342551546","https://openalex.org/W4411611666"],"abstract_inverted_index":{"Age-related":[0],"macular":[1,48],"degeneration":[2],"(AMD)":[3],"is":[4],"one":[5],"of":[6,10,25,70,104,129,168],"the":[7,20,23,113,127,165],"major":[8],"causes":[9],"irreversible":[11],"blindness":[12],"both":[13],"in":[14,52,110,145,157,175],"developed":[15],"and":[16,117,164,173],"developing":[17],"countries.":[18],"During":[19],"past":[21],"decades,":[22],"managements":[24],"neovascular":[26],"AMD":[27,40,137],"(wet":[28],"AMD)":[29,42],"have":[30,56],"dramatically":[31],"progressed.":[32],"However,":[33],"still":[34],"no":[35],"effective":[36],"treatment":[37],"for":[38,135],"non-neovascular":[39],"(dry":[41],"which":[43],"was":[44],"characterized":[45],"by":[46,86,102],"geographic":[47],"atrophy.":[49],"Recent":[50],"advances":[51,156],"stem":[53,71,75,79,82,130,158],"cell":[54,87,131,133,159],"sciences":[55],"demonstrated":[57],"that":[58,96],"retinal":[59],"pigment":[60],"epithelium":[61],"(RPE)":[62],"cells":[63,72,106],"can":[64],"be":[65,100,180],"generated":[66],"from":[67],"several":[68,122],"types":[69],"(including":[73],"embryonic":[74],"cells,":[76,80,83],"induced":[77],"pluripotent":[78],"mesenchymal":[81],"et":[84],"al)":[85],"co-culturing":[88],"or":[89],"defined":[90],"factors.":[91],"Additionally,":[92],"studies":[93,147],"also":[94,179],"showed":[95],"visual":[97],"function":[98],"could":[99],"recovered":[101],"transplantation":[103,134],"these":[105,146],"into":[107],"subretinal":[108],"space":[109],"vivo.":[111],"Moreover,":[112],"United":[114],"States":[115],"Food":[116],"Drug":[118],"Administration":[119],"already":[120],"approved":[121],"clinical":[123,169],"trials":[124],"to":[125],"evaluate":[126],"efficiencies":[128],"based":[132,160],"dry":[136],"patients.":[138],"Till":[139],"now,":[140],"a":[141],"few":[142],"patients":[143],"enrolled":[144],"achieved":[148],"promising":[149],"outcomes.":[150],"This":[151],"review":[152],"will":[153,178],"summarize":[154],"recent":[155],"RPE":[161],"differentiation,":[162],"transplantation,":[163],"preliminary":[166],"results":[167],"trials.":[170],"The":[171],"obstacles":[172],"prospects":[174],"this":[176],"field":[177],"discussed.":[181]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
