{"id":"https://openalex.org/W1483365849","doi":null,"title":"Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.","display_name":"Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.","publication_year":1981,"publication_date":"1981-02-01","ids":{"openalex":"https://openalex.org/W1483365849","mag":"1483365849","pmid":"https://pubmed.ncbi.nlm.nih.gov/7008623","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1903688"},"language":"en","primary_location":{"id":"pmid:7008623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7008623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W1483365849"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1903688/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040192225","display_name":"J. L. Farber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Farber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107559060","display_name":"Kenneth R. Chien","orcid":"https://orcid.org/0000-0002-2759-8378","observed_orcids":["https://orcid.org/0000-0002-2759-8378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K R Chien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012822644","display_name":"S. Mittnacht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Mittnacht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0775,"has_fulltext":false,"cited_by_count":442,"citation_normalized_percentile":{"value":0.94444444,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"102","issue":"2","first_page":"271","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cell-membrane-damage","display_name":"cell membrane damage","score":0.8069999814033508},{"id":"https://openalex.org/keywords/phospholipid-metabolism","display_name":"phospholipid metabolism","score":0.8539999723434448},{"id":"https://openalex.org/keywords/adenine-nucleotide-translocation","display_name":"adenine nucleotide translocation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.7580000162124634},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9169999957084656},{"id":"https://openalex.org/keywords/reoxygenation","display_name":"reoxygenation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.7770000100135803},{"id":"https://openalex.org/keywords/phospholipase-activation","display_name":"phospholipase activation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9409999847412109},{"id":"https://openalex.org/keywords/energy-depletion","display_name":"energy depletion","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6905898451805115},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6074371337890625},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5846906304359436},{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.5504336953163147},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5503336191177368},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.5141830444335938},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5134859681129456},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4754202961921692},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4334624111652374},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.396640419960022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39196082949638367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36813369393348694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3506157398223877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28031328320503235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2381291687488556},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.21448764204978943},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.14794114232063293},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002746","descriptor_name":"Chlorpromazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7008623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7008623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1903688","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1903688/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:1483365849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7008623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1903688","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1903688/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W9623127","https://openalex.org/W14681177","https://openalex.org/W52393367","https://openalex.org/W60476445","https://openalex.org/W60748611","https://openalex.org/W114242172","https://openalex.org/W147294650","https://openalex.org/W302119814","https://openalex.org/W313738879","https://openalex.org/W1029688286","https://openalex.org/W1465921970","https://openalex.org/W1480051253","https://openalex.org/W1485806421","https://openalex.org/W1500536335","https://openalex.org/W1507410890","https://openalex.org/W1508621167","https://openalex.org/W1528492966","https://openalex.org/W1529306244","https://openalex.org/W1536035248","https://openalex.org/W1541054247","https://openalex.org/W1553292475","https://openalex.org/W1567313097","https://openalex.org/W1574721503","https://openalex.org/W1580444077","https://openalex.org/W1592623275","https://openalex.org/W1601392547","https://openalex.org/W1608744359","https://openalex.org/W1673932087","https://openalex.org/W1717897856","https://openalex.org/W1735059796","https://openalex.org/W1952575201","https://openalex.org/W1968361632","https://openalex.org/W1969939360","https://openalex.org/W1973566225","https://openalex.org/W1977174086","https://openalex.org/W1987168559","https://openalex.org/W1987311161","https://openalex.org/W1987639618","https://openalex.org/W1992154702","https://openalex.org/W1992295993","https://openalex.org/W1996723509","https://openalex.org/W2006789097","https://openalex.org/W2009240157","https://openalex.org/W2011834823","https://openalex.org/W2020711450","https://openalex.org/W2030655590","https://openalex.org/W2030878900","https://openalex.org/W2035857494","https://openalex.org/W2038225831","https://openalex.org/W2038936464","https://openalex.org/W2039388809","https://openalex.org/W2040890373","https://openalex.org/W2048326869","https://openalex.org/W2055069207","https://openalex.org/W2061487243","https://openalex.org/W2063316977","https://openalex.org/W2065407582","https://openalex.org/W2065462395","https://openalex.org/W2069538047","https://openalex.org/W2069565720","https://openalex.org/W2073974448","https://openalex.org/W2074086454","https://openalex.org/W2076176291","https://openalex.org/W2076472874","https://openalex.org/W2078149191","https://openalex.org/W2079400370","https://openalex.org/W2083632839","https://openalex.org/W2092409739","https://openalex.org/W2094557223","https://openalex.org/W2111031157","https://openalex.org/W2115638394","https://openalex.org/W2126249768","https://openalex.org/W2135143144","https://openalex.org/W2143046500","https://openalex.org/W2144708655","https://openalex.org/W2160261406","https://openalex.org/W2395565651","https://openalex.org/W2409255115","https://openalex.org/W2414895299","https://openalex.org/W2423124747","https://openalex.org/W2471464769","https://openalex.org/W2475083172","https://openalex.org/W3195820525","https://openalex.org/W4231562630"],"related_works":["https://openalex.org/W1981053322","https://openalex.org/W198635319","https://openalex.org/W54566154","https://openalex.org/W4237805246","https://openalex.org/W2265800924","https://openalex.org/W1992797118","https://openalex.org/W1981102657","https://openalex.org/W2162473029","https://openalex.org/W1823454189","https://openalex.org/W3195820525"],"abstract_inverted_index":{"Cells":[0],"made":[1],"ischemic":[2,47,60,242],"rapidly":[3],"manifest":[4],"many":[5],"distinct":[6],"structural":[7],"and":[8,68,89,120,183,189,193,238],"functional":[9,239],"alterations":[10],"as":[11,222],"a":[12,123],"consequence":[13],"of":[14,17,26,45,70,96,98,103,116,122,129,187,198,209,232,241],"the":[15,32,36,40,43,46,62,76,85,90,127,130,142,151,169,181,195,223,236],"depletion":[16,153],"their":[18],"energy":[19],"stores.":[20],"In":[21],"attempting":[22],"to":[23,31,42,57,64,92,108,167],"determine":[24],"which":[25],"these":[27,99],"are":[28,79,106,136,245],"causally":[29],"related":[30,107],"eventual":[33],"cell":[34,94,175,243],"death,":[35],"authors":[37],"have":[38,51,82],"emphasized":[39],"relationship":[41,91],"reversibility":[44],"injury.":[48],"Two":[49],"phenomena":[50],"consistently":[52],"characterized":[53],"irreversibly":[54],"in":[55,75,110,126,145,162,177,235],"contrast":[56],"reversibly":[58],"injured":[59],"cells:":[61],"inability":[63],"restore":[65],"mitochondrial":[66,104,132],"function":[67],"evidence":[69],"plasma":[71,196],"membrane":[72],"damage.":[73],"Studies":[74],"authors'":[77],"laboratory":[78],"reviewed":[80],"that":[81,149,172],"focused":[83],"on":[84],"pathogenesis,":[86],"biochemical":[87],"nature,":[88],"irreversible":[93,174],"injury":[95,176,244],"both":[97],"alterations.":[100],"A":[101],"number":[102],"abnormalities":[105],"changes":[109,135],"long-chain":[111],"acyl-CoA":[112],"metabolism":[113,164],"with":[114,205],"inhibition":[115],"adenine":[117],"nucleotide":[118],"translocation":[119],"potentiation":[121],"Ca2+-dependent":[124],"increase":[125,144],"permeability":[128],"inner":[131],"membrane.":[133],"These":[134],"reversible":[137],"upon":[138],"reoxygenation":[139],"only":[140],"when":[141],"large":[143],"intracellular":[146,233],"Ca2+":[147,217,234],"content":[148],"accompanies":[150],"phospholipid":[152,163,227],"from":[154],"other":[155],"cellular":[156],"membranes":[157,186,197],"is":[158,165,201,220],"prevented.":[159],"This":[160],"disorder":[161],"felt":[166],"be":[168],"critical":[170],"lesion":[171],"produces":[173],"ischemia.":[178],"It":[179,200],"affects":[180],"endoplasmic":[182],"sarcoplasmic":[184],"reticular":[185],"liver":[188],"myocardial":[190],"cells,":[191],"respectively,":[192],"probably":[194],"both.":[199],"prevented":[202],"by":[203,212],"pretreatment":[204],"chlorpromazine.":[206],"An":[207],"activation":[208],"endogenous":[210],"phospholipases":[211],"an":[213],"elevated,":[214],"cytosolic":[215],"free":[216],"ion":[218],"concentration":[219],"suggested":[221],"mechanism":[224],"underlying":[225],"this":[226],"disturbance.":[228],"The":[229],"central":[230],"role":[231],"initiation":[237],"consequences":[240],"emphasized.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}