{"id":"https://openalex.org/W148301145","doi":"https://doi.org/10.3748/wjg.v20.i43.16146","title":"Calcium signaling of pancreatic acinar cells in the pathogenesis of pancreatitis","display_name":"Calcium signaling of pancreatic acinar cells in the pathogenesis of pancreatitis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W148301145","doi":"https://doi.org/10.3748/wjg.v20.i43.16146","mag":"148301145","pmid":"https://pubmed.ncbi.nlm.nih.gov/25473167","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4239501"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v20.i43.16146","doi":"https://doi.org/10.3748/wjg.v20.i43.16146","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v20.i43.16146","pdf_url":"https://www.wjgnet.com/1007-9327/full/v20/i43/16146.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v20/i43/16146.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100361737","display_name":"Jun Li","orcid":"https://orcid.org/0000-0001-9940-3421","observed_orcids":["https://orcid.org/0000-0001-9940-3421","https://orcid.org/0000-0001-6448-8568"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zhou","raw_affiliation_strings":["Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409987","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-6558-791X","observed_orcids":["https://orcid.org/0000-0002-6558-791X"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030511983","display_name":"Zongfang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zong-Fang Li","raw_affiliation_strings":["Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jun Li, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, Shaanxi Province, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6294,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.48268921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"43","first_page":"16146","last_page":"16146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pancreatic-acinar-cells","display_name":"pancreatic acinar cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/calcium-overload","display_name":"calcium overload","score":0.9750000238418579},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-calcium-stores","display_name":"endoplasmic reticulum calcium stores","score":0.8569999933242798},{"id":"https://openalex.org/keywords/plasma-membrane-calcium-atpase","display_name":"plasma membrane calcium ATPase","score":0.7599999904632568},{"id":"https://openalex.org/keywords/sarco-endoplasmic-reticulum-ca2-atpase","display_name":"sarco/endoplasmic reticulum Ca2+-ATPase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/trypsin-activation","display_name":"trypsin activation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/acinar-cell-necrosis","display_name":"acinar cell necrosis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bile","display_name":"bile","score":0.6460000276565552},{"id":"https://openalex.org/keywords/alcohol-metabolites","display_name":"alcohol metabolites","score":0.8960000276565552},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.4819999933242798},{"id":"https://openalex.org/keywords/digestive-enzyme-secretion","display_name":"digestive enzyme secretion","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.748640239238739},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7418450117111206},{"id":"https://openalex.org/C2991930265","wikidata":"https://www.wikidata.org/wiki/Q5062943","display_name":"Acinar cell","level":3,"score":0.7019048929214478},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6433584094047546},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.6010969877243042},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.4630686342716217},{"id":"https://openalex.org/C2778614373","wikidata":"https://www.wikidata.org/wiki/Q7908033","display_name":"Vacuolization","level":2,"score":0.4541853666305542},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45195525884628296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4216427803039551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.419824481010437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41466620564460754},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.368987500667572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34143325686454773},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3373708724975586}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D046790","descriptor_name":"Pancreas, Exocrine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D046790","descriptor_name":"Pancreas, Exocrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046790","descriptor_name":"Pancreas, Exocrine","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3748/wjg.v20.i43.16146","doi":"https://doi.org/10.3748/wjg.v20.i43.16146","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v20.i43.16146","pdf_url":"https://www.wjgnet.com/1007-9327/full/v20/i43/16146.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4239501","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4239501","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:25473167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25473167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3748/wjg.v20.i43.16146","doi":"https://doi.org/10.3748/wjg.v20.i43.16146","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v20.i43.16146","pdf_url":"https://www.wjgnet.com/1007-9327/full/v20/i43/16146.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5223244375","display_name":"\u5927\u9ec4\u7d20\u3001\u9ec4\u82a9\u7d20\u8054\u5408\u5e94\u7528\u5bf9\u91cd\u75c7\u6025\u6027\u80f0\u817a\u708e\u5927\u9f20\u813e\u810f\u708e\u75c7\u56e0\u5b50\u5206\u6ccc\u53ca\u80f0\u817a\u817a\u6ce1\u7ec6\u80de\u9499\u8d85\u8f7d\u7684\u5e72\u9884\u4f5c\u7528\u53ca\u5176\u673a\u5236\u7814\u7a76","funder_award_id":"30901945","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8380204484","display_name":null,"funder_award_id":"30171167","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336024","display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W148301145.pdf","grobid_xml":"https://content.openalex.org/works/W148301145.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W146690191","https://openalex.org/W1575866307","https://openalex.org/W1607531254","https://openalex.org/W1893590428","https://openalex.org/W1963742574","https://openalex.org/W1966051958","https://openalex.org/W1968818999","https://openalex.org/W1970691000","https://openalex.org/W1974047868","https://openalex.org/W1978593035","https://openalex.org/W1979573066","https://openalex.org/W1980948951","https://openalex.org/W1981147590","https://openalex.org/W1984369622","https://openalex.org/W1985730861","https://openalex.org/W1988660732","https://openalex.org/W1997018082","https://openalex.org/W1998400705","https://openalex.org/W2009225251","https://openalex.org/W2010572143","https://openalex.org/W2015426350","https://openalex.org/W2016417523","https://openalex.org/W2024097814","https://openalex.org/W2038613283","https://openalex.org/W2039952090","https://openalex.org/W2045648578","https://openalex.org/W2046196975","https://openalex.org/W2052913098","https://openalex.org/W2062810465","https://openalex.org/W2067406751","https://openalex.org/W2069729213","https://openalex.org/W2069945478","https://openalex.org/W2070756686","https://openalex.org/W2073147356","https://openalex.org/W2074113541","https://openalex.org/W2074717002","https://openalex.org/W2075270738","https://openalex.org/W2078397257","https://openalex.org/W2078762947","https://openalex.org/W2081359464","https://openalex.org/W2082588556","https://openalex.org/W2083598194","https://openalex.org/W2087140031","https://openalex.org/W2087510642","https://openalex.org/W2089434495","https://openalex.org/W2093551477","https://openalex.org/W2097265484","https://openalex.org/W2101586949","https://openalex.org/W2104789521","https://openalex.org/W2105849473","https://openalex.org/W2109103859","https://openalex.org/W2109978337","https://openalex.org/W2118259416","https://openalex.org/W2131467340","https://openalex.org/W2131893215","https://openalex.org/W2132204920","https://openalex.org/W2133411368","https://openalex.org/W2136369816","https://openalex.org/W2137258759","https://openalex.org/W2137387994","https://openalex.org/W2137565449","https://openalex.org/W2138974825","https://openalex.org/W2152080897","https://openalex.org/W2163529058","https://openalex.org/W2163789582","https://openalex.org/W2164590065","https://openalex.org/W2166076325","https://openalex.org/W2171359667","https://openalex.org/W4210998956","https://openalex.org/W4211038207","https://openalex.org/W4234366718"],"related_works":["https://openalex.org/W2388044548","https://openalex.org/W2743060829","https://openalex.org/W4415333426","https://openalex.org/W2155710425","https://openalex.org/W2997996275","https://openalex.org/W29649499","https://openalex.org/W2078639432","https://openalex.org/W2895737365","https://openalex.org/W2233601907","https://openalex.org/W14673201"],"abstract_inverted_index":{"Pancreatitis":[0],"is":[1,18,25,53,59,82,195,203],"an":[2,197],"increasingly":[3],"common":[4],"and":[5,37,58,79,95,105,150,160,179,210],"sometimes":[6],"severe":[7],"disease":[8],"that":[9,99],"lacks":[10],"a":[11,26,39,54,83],"specific":[12,193],"therapy.":[13],"The":[14,189],"pathogenesis":[15,63,217],"of":[16,29,34,64,89,108,115,119,138,152,181,191,199,212,218],"pancreatitis":[17],"still":[19],"not":[20],"well":[21],"understood.":[22],"Calcium":[23],"(Ca(2+))":[24],"versatile":[27],"carrier":[28],"signals":[30,186,214],"regulating":[31],"many":[32,65],"aspects":[33],"cellular":[35],"activity":[36],"plays":[38],"central":[40],"role":[41],"in":[42,47,61,101,112,123,187,215],"controlling":[43],"digestive":[44],"enzyme":[45],"secretion":[46],"pancreatic":[48,68,183],"acinar":[49,69,184],"cells.":[50],"Ca(2+)":[51,72,97,120,130,153,168,185,213],"overload":[52],"key":[55,84],"early":[56],"event":[57],"crucial":[60,111],"the":[62,87,113,124,133,155,177,208,216],"diseases.":[66],"In":[67],"cells,":[70],"pathological":[71],"signaling":[73],"(stimulated":[74],"by":[75,154],"bile,":[76],"alcohol":[77],"metabolites":[78],"other":[80],"causes)":[81],"contributor":[85],"to":[86,93,167,206],"initiation":[88],"cell":[90,140],"injury":[91],"due":[92],"prolonged":[94],"global":[96],"elevation":[98],"results":[100],"trypsin":[102],"activation,":[103],"vacuolization":[104],"necrosis,":[106],"all":[107],"which":[109,165],"are":[110,136],"development":[114],"pancreatitis.":[116,188,219],"Increased":[117],"release":[118],"from":[121],"stores":[122],"intracellular":[125],"endoplasmic":[126],"reticulum":[127,157],"and/or":[128],"increased":[129],"entry":[131],"through":[132],"plasma":[134,161],"membrane":[135,162],"causes":[137],"such":[139],"damage.":[141],"Failed":[142],"mitochondrial":[143],"adenosine":[144],"triphosphate":[145],"(ATP)":[146],"production":[147],"reduces":[148],"re-uptake":[149],"extrusion":[151],"sarco/endoplasmic":[156],"Ca(2+)-activated":[158],"ATPase":[159],"Ca(2+)-ATPase":[163],"pumps,":[164],"contribute":[166],"overload.":[169],"Current":[170],"findings":[171],"have":[172],"provided":[173],"further":[174],"insight":[175],"into":[176],"roles":[178],"mechanisms":[180,209],"abnormal":[182],"lack":[190],"available":[192],"treatments":[194],"therefore":[196],"objective":[198],"ongoing":[200],"research.":[201],"Research":[202],"currently":[204],"underway":[205],"establish":[207],"interactions":[211]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
