{"id":"https://openalex.org/W1483000936","doi":null,"title":"Simulated microgravity increases cutaneous blood flow in the head and leg of humans.","display_name":"Simulated microgravity increases cutaneous blood flow in the head and leg of humans.","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W1483000936","mag":"1483000936","pmid":"https://pubmed.ncbi.nlm.nih.gov/7487826"},"language":"en","primary_location":{"id":"pmid:7487826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7487826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034692602","display_name":"M S Stout","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Stout","raw_affiliation_strings":["National Aeronautics and Space Administration, Ames Research Center, Life Science Division, Moffett Field, CA 94035-1000, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Aeronautics and Space Administration, Ames Research Center, Life Science Division, Moffett Field, CA 94035-1000, USA","institution_ids":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031271074","display_name":"Donald E. Watenpaugh","orcid":"https://orcid.org/0000-0003-3188-5297","observed_orcids":["https://orcid.org/0000-0003-3188-5297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Watenpaugh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111421006","display_name":"Gregory A. Breit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G A Breit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019920223","display_name":"A R Hargens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A R Hargens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4316,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.57474513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"66","issue":"9","first_page":"872","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.902999997138977},{"id":"https://openalex.org/keywords/head-down-tilt","display_name":"head-down tilt","score":0.9760000109672546},{"id":"https://openalex.org/keywords/skin-blood-flow","display_name":"skin blood flow","score":0.9700000286102295},{"id":"https://openalex.org/keywords/skin-microcirculation","display_name":"skin microcirculation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sympathetic-withdrawal","display_name":"sympathetic withdrawal","score":0.699999988079071},{"id":"https://openalex.org/keywords/myogenic-vasoconstriction","display_name":"myogenic vasoconstriction","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hydrostatic-pressure","display_name":"hydrostatic pressure","score":0.640999972820282},{"id":"https://openalex.org/keywords/leg-blood-flow","display_name":"leg blood flow","score":0.5649999976158142},{"id":"https://openalex.org/keywords/facial-blood-flow","display_name":"facial blood flow","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6684602499008179},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6095582246780396},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5911459922790527},{"id":"https://openalex.org/C52305850","wikidata":"https://www.wikidata.org/wiki/Q1420475","display_name":"Laser Doppler velocimetry","level":3,"score":0.543600857257843},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.47084328532218933},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.45584315061569214},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4488610327243805},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.4269687533378601},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4245033264160156},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3802124857902527},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3779071867465973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37181955575942993},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2011605203151703}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006257","descriptor_name":"Head","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018470","descriptor_name":"Gravity, Altered","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7487826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7487826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},{"id":"mag:1483000936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7487826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W262391891","https://openalex.org/W302425889","https://openalex.org/W305475442","https://openalex.org/W1568906377","https://openalex.org/W1605399258","https://openalex.org/W1755781900","https://openalex.org/W1844862155","https://openalex.org/W1876758225","https://openalex.org/W1949209377","https://openalex.org/W1963705350","https://openalex.org/W1973919421","https://openalex.org/W1980071663","https://openalex.org/W2007785858","https://openalex.org/W2017598358","https://openalex.org/W2019809072","https://openalex.org/W2030556921","https://openalex.org/W2046182586","https://openalex.org/W2050400910","https://openalex.org/W2063343826","https://openalex.org/W2084198027","https://openalex.org/W2092935668","https://openalex.org/W2096512275","https://openalex.org/W2110741309","https://openalex.org/W2111294899","https://openalex.org/W2158215946","https://openalex.org/W2259110695","https://openalex.org/W2305860405","https://openalex.org/W2395774959","https://openalex.org/W2409774897","https://openalex.org/W2462063871","https://openalex.org/W2462287476"],"related_works":["https://openalex.org/W2732375655","https://openalex.org/W305475442","https://openalex.org/W77966549","https://openalex.org/W4299285265","https://openalex.org/W1980071663","https://openalex.org/W2049478851","https://openalex.org/W2081798132","https://openalex.org/W804434019","https://openalex.org/W1968301507","https://openalex.org/W4408192794"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"cutaneous":[2,42,58,255],"microcirculation":[3],"vasodilates":[4],"during":[5,49,101,228,257],"acute":[6],"6":[7],"degrees":[8],"head-down":[9],"tilt":[10],"(HDT,":[11],"simulated":[12,53],"microgravity)":[13],"relative":[14,32],"to":[15,52,114,130,193,219,246,282,296],"upright":[16,103,182],"conditions,":[17],"more":[18,251],"in":[19,24,109,149,254,287],"the":[20,25,66,69,75,110,150,180,209,224,231,260],"lower":[21,40,290],"body":[22,41,293],"than":[23],"upper":[26,38,292],"body.":[27],"HYPOTHESIS:":[28],"We":[29,56],"expected":[30],"that":[31],"magnitudes":[33],"of":[34,78,88,96,202,214,239,276,289],"and":[35,39,72,84,168,187,226,242,250,291,298],"differences":[36,286],"between":[37],"blood":[43,60,107,189,294],"flow":[44,61,108,148,190,256,271,295],"elevation":[45,272],"would":[46],"be":[47],"sustained":[48,252],"initial":[50],"acclimation":[51,288],"microgravity.":[54,300],"METHODS:":[55],"measured":[57,100],"microvascular":[59,221],"with":[62,236],"laser-Doppler":[63],"flowmetry":[64],"at":[65,124,164,172,208,223],"leg":[67,151,188,227],"(over":[68,74],"distal":[70],"tibia)":[71],"cheek":[73,111,186],"zygomatic":[76],"arch)":[77],"eight":[79],"healthy":[80],"men":[81],"before,":[82],"during,":[83],"after":[85],"24":[86,135,158,173,274],"h":[87,126,136,159,166,174,275],"HDT.":[89,229,258,277],"Results":[90],"were":[91],"calculated":[92],"as":[93],"a":[94],"percentage":[95],"baseline":[97,132,156,196],"value":[98],"(100%":[99],"pre-tilt":[102,195],"sitting).":[104],"RESULTS:":[105],"Cutaneous":[106],"increased":[112,143,220],"significantly":[113,153],"165":[115],"+/-":[116,119,139,162,170],"37%":[117],"(mean":[118],"SE,":[120],"p":[121,176],"<":[122,177],"0.05)":[123],"9-12":[125],"HDT,":[127,175],"then":[128],"returned":[129,192],"near":[131,194],"values":[133],"by":[134,273],"HDT":[137,160,167,203,297],"(114":[138],"29%,":[140],"NSD),":[141],"despite":[142],"local":[144,205,240],"arterial":[145,206],"pressure.":[146],"Microvascular":[147],"remained":[152],"elevated":[154],"above":[155],"throughout":[157],"(427":[161],"85%":[163],"3":[165],"215":[169],"142%":[171],"0.05).":[178],"During":[179],"6-h":[181],"sitting":[183],"recovery":[184],"period,":[185],"levels":[191],"values.":[197],"CONCLUSIONS:":[198],"Because":[199],"hydrostatic":[200],"effects":[201,234,267],"increase":[204],"pressure":[207],"carotid":[210],"sinus,":[211],"baroreflex-mediated":[212],"withdrawal":[213],"sympathetic":[215],"tone":[216],"probably":[217,284],"contributed":[218],"flows":[222],"head":[225],"In":[230,259],"leg,":[232],"baroreflex":[233],"combined":[235],"minimal":[237],"stimulation":[238],"veno-arteriolar":[241],"myogenic":[243,263],"autoregulatory":[244],"vasoconstriction":[245,264],"elicit":[247],"relatively":[248],"larger":[249],"increases":[253],"cheek,":[261],"delayed":[262],"and/or":[265],"humoral":[266],"apparently":[268],"compensated":[269],"for":[270],"Therefore,":[278],"localized":[279],"vascular":[280],"adaptations":[281],"gravity":[283],"explain":[285],"actual":[299]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}