{"id":"https://openalex.org/W1482816174","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1048.1","title":"Toll\u2010like receptor 9 Activation Contributes to Decreased Autophagy in Hypertension","display_name":"Toll\u2010like receptor 9 Activation Contributes to Decreased Autophagy in Hypertension","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1482816174","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1048.1","mag":"1482816174"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.1048.1","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1048.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.1048.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028006240","display_name":"Cameron Grant McCarthy","orcid":"https://orcid.org/0000-0002-1380-779X","observed_orcids":["https://orcid.org/0000-0002-1380-779X"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron McCarthy","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Department of Physiology Georgia Regents University Augusta GA United States","1--> Department of Physiology Georgia Regents University Augusta GA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Department of Physiology Georgia Regents University Augusta GA United States","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"1--> Department of Physiology Georgia Regents University Augusta GA United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022191748","display_name":"Camilla Ferreira Wenceslau","orcid":"https://orcid.org/0000-0002-0815-3568","observed_orcids":["https://orcid.org/0000-0002-0815-3568"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camilla Wenceslau","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Department of Physiology Georgia Regents University Augusta GA United States","1--> Department of Physiology Georgia Regents University Augusta GA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Department of Physiology Georgia Regents University Augusta GA United States","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"1--> Department of Physiology Georgia Regents University Augusta GA United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008603598","display_name":"Styliani Goulopoulou","orcid":"https://orcid.org/0000-0001-7636-8256","observed_orcids":["https://orcid.org/0000-0001-7636-8256"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Styliani Goulopoulou","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Department of Integrative Physiology and Anatomy and Obstetrics and Gynecology University of North Texas Health Science Center Fort Worth TX United States","2--> Department of Integrative Physiology and Anatomy and Obstetrics and Gynecology University of North Texas Health Science Center Fort Worth TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Department of Integrative Physiology and Anatomy and Obstetrics and Gynecology University of North Texas Health Science Center Fort Worth TX United States","institution_ids":["https://openalex.org/I165139151"]},{"raw_affiliation_string":"2--> Department of Integrative Physiology and Anatomy and Obstetrics and Gynecology University of North Texas Health Science Center Fort Worth TX United States","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101608662","display_name":"Robert Clinton Webb","orcid":"https://orcid.org/0009-0009-9403-305X","observed_orcids":["https://orcid.org/0009-0009-9403-305X","https://orcid.org/0000-0002-7691-5261"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Clinton Webb","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Department of Physiology Georgia Regents University Augusta GA United States","1--> Department of Physiology Georgia Regents University Augusta GA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Department of Physiology Georgia Regents University Augusta GA United States","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"1--> Department of Physiology Georgia Regents University Augusta GA United States","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03254519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.9449999928474426},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dnase-i","display_name":"DNase I","score":0.5730000138282776},{"id":"https://openalex.org/keywords/dnase-ii","display_name":"DNase II","score":0.9980000257492065},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":0.949999988079071},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.8479999899864197},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.7599999904632568},{"id":"https://openalex.org/keywords/resistance-arteries","display_name":"resistance arteries","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tlr9-agonist","display_name":"TLR9 agonist","score":0.8960000276565552},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8792250752449036},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.5882429480552673},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5610005855560303},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5513802766799927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5329225063323975},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.5279088616371155},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.47324877977371216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4638979434967041},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4622238874435425},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3809118866920471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36492210626602173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22103986144065857},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15063679218292236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1199633777141571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07006844878196716},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.1048.1","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1048.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.1048.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044318535","https://openalex.org/W2899424227","https://openalex.org/W3015435056","https://openalex.org/W4207046469","https://openalex.org/W4200237077","https://openalex.org/W3173500511","https://openalex.org/W2800367776","https://openalex.org/W2971769193","https://openalex.org/W4408474413","https://openalex.org/W7161143303"],"abstract_inverted_index":{"Autophagy":[0],"is":[1],"a":[2,32,144,192],"catabolic":[3],"process":[4,16],"for":[5,14,67,71,195],"cell":[6,22],"survival":[7],"in":[8,104,122,137,173,198,203,218],"times":[9],"of":[10,34,40,57,87,96,119,125,140,166,188,208,216],"stress.":[11],"However,":[12],"dysregulation":[13,215],"this":[15,112],"can":[17],"have":[18,46,53],"detrimental":[19],"effects":[20],"on":[21],"survival.":[23],"In":[24],"fact,":[25],"insufficient":[26],"autophagy":[27,101,217],"has":[28],"been":[29],"proposed":[30],"as":[31],"mechanism":[33,194],"apoptosis":[35],"due":[36],"to":[37,84,111],"the":[38,58,68,85,123,164,178,196,199,214],"accumulation":[39],"proteins":[41,98,121],"and":[42,77,79,106,129,131,162,169,177],"defective":[43],"organelles.":[44],"We":[45,115],"observed":[47,116,202],"that":[48,94,107,186],"spontaneously":[49],"hypertensive":[50],"rats":[51,142],"(SHR)":[52],"elevated":[54],"circulating":[55],"levels":[56],"damage\u2010associated":[59],"molecular":[60],"pattern":[61],"mitochondrial":[62],"DNA":[63],"(mtDNA),":[64],"diminished":[65],"activity":[66],"enzymes":[69],"responsible":[70],"its":[72],"degradation,":[73],"deoxyribonuclease":[74],"(DNase)":[75],"I":[76],"II,":[78],"these":[80],"novel":[81],"phenotypes":[82],"contribute":[83],"activation":[86,109],"Toll\u2010like":[88],"receptor":[89],"(TLR)9.":[90],"Therefore,":[91,205],"we":[92],"hypothesized":[93],"expression":[95,118,165],"representative":[97],"associated":[99],"with":[100,143],"are":[102],"decreased":[103,117,163],"SHR":[105,126],"TLR9":[108,146,189,211],"contributes":[110],"down":[113],"regulation.":[114],"autophagic":[120,200],"aorta":[124,179],"(Beclin\u20101,":[127],"ATG5,":[128],"LC3\u2010I":[130],"\u2010II)":[132],"(p<0.05":[133,180],"vs.":[134,158,181],"WKY).":[135],"Moreover,":[136],"vivo":[138],"treatment":[139],"normotensive":[141],"synthetic":[145],"agonist":[147],"(ODN2395;":[148],"0.1":[149],"\u03bcg/i.p.),":[150],"increased":[151],"systolic":[152],"blood":[153],"pressure":[154],"(mmHg,":[155],"Veh:":[156],"141\u00b13":[157],"ODN2395:":[159],"154\u00b13,":[160],"p<0.05)":[161],"ubiquitin\u2010like":[167],"protein":[168],"autophagosomal":[170],"marker":[171],"LC3\u2010II":[172],"both":[174],"resistance":[175],"arteries":[176],"Vehicle).":[182],"These":[183],"results":[184],"suggest":[185],"stimulation":[187],"may":[190],"be":[191],"contributing":[193],"reduction":[197],"machinery":[201],"SHR.":[204],"targeted":[206],"inhibition":[207],"mtDNA":[209],"and/or":[210],"could":[212],"prevent":[213],"hypertension.":[219]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
