{"id":"https://openalex.org/W148264871","doi":null,"title":"Insulin resistance pathogenesis in visceral fat and gut organisms","display_name":"Insulin resistance pathogenesis in visceral fat and gut organisms","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W148264871","mag":"148264871"},"language":"en","primary_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/12560","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2123/12560","pdf_url":"http://hdl.handle.net/2123/12560","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Book chapter"},"volume":null,"type":"book-chapter","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2123/12560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024614916","display_name":"Yan Y. Lam","orcid":"https://orcid.org/0000-0002-5724-1142","observed_orcids":["https://orcid.org/0000-0002-5724-1142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Y. Lam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5724-1142","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003810725","display_name":"Connie W. Y. Ha","orcid":"https://orcid.org/0000-0003-1357-6431","observed_orcids":["https://orcid.org/0000-0003-1357-6431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Connie Ha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1357-6431","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013337848","display_name":"Andrew J. Holmes","orcid":"https://orcid.org/0000-0002-7406-4387","observed_orcids":["https://orcid.org/0000-0002-7406-4387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Holmes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7406-4387","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06611215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.3474000096321106,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.9150000214576721},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.6930000185966492},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9070000052452087},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.621999979019165},{"id":"https://openalex.org/keywords/mesenteric-fat-inflammation","display_name":"mesenteric fat inflammation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/portal-vein","display_name":"portal vein","score":0.7170000076293945},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/microbial-metabolites","display_name":"microbial metabolites","score":0.5789999961853027},{"id":"https://openalex.org/keywords/visceral-fat-deposition","display_name":"visceral fat deposition","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8414702415466309},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7020650506019592},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6167827844619751},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5665268301963806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5456869602203369},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.507963240146637},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.48602038621902466},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4709763526916504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.467214971780777},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.45921942591667175},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4307992160320282},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4293268024921417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34278979897499084},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15321528911590576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09846341609954834}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ses.library.usyd.edu.au:2123/12560","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2123/12560","pdf_url":"http://hdl.handle.net/2123/12560","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Book chapter"},{"id":"mag:148264871","doi":null,"is_oa":false,"landing_page_url":"http://ses.library.usyd.edu.au/handle/2123/12560","pdf_url":null,"source":{"id":"https://openalex.org/S4306463966","display_name":"Sydney University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Sydney University Press eBooks","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/12560","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2123/12560","pdf_url":"http://hdl.handle.net/2123/12560","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Book chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W148264871.pdf","grobid_xml":"https://content.openalex.org/works/W148264871.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W146249449","https://openalex.org/W1569693056","https://openalex.org/W1789177142","https://openalex.org/W1902824041","https://openalex.org/W1952460190","https://openalex.org/W1953244638","https://openalex.org/W1964355923","https://openalex.org/W1965592577","https://openalex.org/W1967217097","https://openalex.org/W1971415551","https://openalex.org/W1972441174","https://openalex.org/W1972886167","https://openalex.org/W1976806178","https://openalex.org/W1980248069","https://openalex.org/W1983220630","https://openalex.org/W1985780203","https://openalex.org/W1986910407","https://openalex.org/W1989400130","https://openalex.org/W1991401793","https://openalex.org/W1991705455","https://openalex.org/W2002570028","https://openalex.org/W2004071001","https://openalex.org/W2005651177","https://openalex.org/W2008869160","https://openalex.org/W2018803560","https://openalex.org/W2020744745","https://openalex.org/W2026852800","https://openalex.org/W2026855997","https://openalex.org/W2031889049","https://openalex.org/W2037833069","https://openalex.org/W2038217946","https://openalex.org/W2046470758","https://openalex.org/W2047192155","https://openalex.org/W2047595952","https://openalex.org/W2048717385","https://openalex.org/W2049349880","https://openalex.org/W2052683965","https://openalex.org/W2052717138","https://openalex.org/W2055421595","https://openalex.org/W2063153781","https://openalex.org/W2066538173","https://openalex.org/W2071085528","https://openalex.org/W2073332363","https://openalex.org/W2079414792","https://openalex.org/W2082578477","https://openalex.org/W2083900555","https://openalex.org/W2090286224","https://openalex.org/W2093614380","https://openalex.org/W2093705034","https://openalex.org/W2093829052","https://openalex.org/W2096961219","https://openalex.org/W2097875133","https://openalex.org/W2097929425","https://openalex.org/W2100478316","https://openalex.org/W2101272036","https://openalex.org/W2102009612","https://openalex.org/W2104890139","https://openalex.org/W2106407243","https://openalex.org/W2106800643","https://openalex.org/W2107856360","https://openalex.org/W2113184924","https://openalex.org/W2115836993","https://openalex.org/W2117222904","https://openalex.org/W2117301113","https://openalex.org/W2119152897","https://openalex.org/W2119573787","https://openalex.org/W2119609179","https://openalex.org/W2120950548","https://openalex.org/W2121908572","https://openalex.org/W2122292664","https://openalex.org/W2122495140","https://openalex.org/W2122779261","https://openalex.org/W2125302795","https://openalex.org/W2126407437","https://openalex.org/W2126660234","https://openalex.org/W2126975980","https://openalex.org/W2127187614","https://openalex.org/W2130495917","https://openalex.org/W2133646769","https://openalex.org/W2135179675","https://openalex.org/W2137536448","https://openalex.org/W2138411980","https://openalex.org/W2138485536","https://openalex.org/W2138489649","https://openalex.org/W2138673784","https://openalex.org/W2139122645","https://openalex.org/W2139833921","https://openalex.org/W2141189887","https://openalex.org/W2141313834","https://openalex.org/W2141878383","https://openalex.org/W2142336938","https://openalex.org/W2142995099","https://openalex.org/W2144509989","https://openalex.org/W2145807308","https://openalex.org/W2149351690","https://openalex.org/W2152024122","https://openalex.org/W2153214557","https://openalex.org/W2153406190","https://openalex.org/W2156029791","https://openalex.org/W2156272127","https://openalex.org/W2156877200","https://openalex.org/W2157373911","https://openalex.org/W2160325274","https://openalex.org/W2161455288","https://openalex.org/W2163691580","https://openalex.org/W2165202791","https://openalex.org/W2166933182","https://openalex.org/W2167062509","https://openalex.org/W2169619812","https://openalex.org/W2182150538","https://openalex.org/W2328579121"],"related_works":["https://openalex.org/W2108887551","https://openalex.org/W2128414457","https://openalex.org/W2506978189","https://openalex.org/W4239282369","https://openalex.org/W2039891295","https://openalex.org/W2057222012","https://openalex.org/W2088519749","https://openalex.org/W2035836390","https://openalex.org/W2359259427","https://openalex.org/W1983548385"],"abstract_inverted_index":{"Epidemiological":[0],"work":[1],"has":[2],"shown":[3],"that":[4,32],"visceral":[5,17,45],"adiposity":[6],"is":[7,23],"strongly":[8],"related":[9],"to":[10,73,101],"metabolic":[11,49],"disorders":[12],"including":[13],"insulin":[14,106],"resistance.What":[15],"regulates":[16],"fat":[18,46,77,85],"deposition":[19],"and":[20,48,70,81,93,104],"why":[21],"it":[22],"so":[24],"metabolically":[25],"deleterious":[26],"remains":[27],"largely":[28],"unclear.Recent":[29],"data":[30],"suggest":[31],"the":[33,42,65,74,84,87,97],"gastrointestinal":[34],"tract":[35],"may":[36],"be":[37],"a":[38,56],"central":[39],"player":[40],"in":[41,79,96],"development":[43],"of":[44,58,67,83,90],"accumulation":[47],"syndrome.An":[50],"impaired":[51],"gut":[52],"barrier":[53],"function,":[54],"as":[55],"consequence":[57],"inflammation":[59,82],"and/or":[60],"altered":[61],"microbiota":[62],"composition,":[63],"increases":[64],"leak":[66],"microbial":[68],"molecules":[69],"their":[71],"metabolites":[72],"adjacent":[75],"mesenteric":[76],"resulting":[78],"hypertrophy":[80],"depot.Subsequently,":[86],"increased":[88],"efflux":[89],"fatty":[91],"acids":[92],"pro-inflammatory":[94],"factors":[95],"portal":[98],"vein":[99],"leads":[100],"liver":[102],"dysfunction":[103],"systemic":[105],"resistance.":[107]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}