{"id":"https://openalex.org/W1482644575","doi":null,"title":"Immunological and Clinical Long-Term Effects of Idiotype Vaccination in Multiple Myeloma Patients","display_name":"Immunological and Clinical Long-Term Effects of Idiotype Vaccination in Multiple Myeloma Patients","publication_year":2007,"publication_date":"2007-02-22","ids":{"openalex":"https://openalex.org/W1482644575","mag":"1482644575"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26900452","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Immunological_and_clinical_long-term_effects_of_idiotype_vaccination_in_multiple_myeloma_patients/26900452","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/39621","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111891601","display_name":"Amir Osman Abdalla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amir Osman Abdalla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111891601"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiotype-vaccination","display_name":"idiotype vaccination","score":0.8090000152587891},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8339999914169312},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9810000061988831},{"id":"https://openalex.org/keywords/th1-th2-polarization","display_name":"Th1/Th2 polarization","score":0.8830000162124634},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-marrow-t-cells","display_name":"bone marrow T cells","score":0.5910000205039978},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.574999988079071},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.4970000088214874},{"id":"https://openalex.org/keywords/long-term-vaccine-effects","display_name":"long-term vaccine effects","score":0.5619999766349792},{"id":"https://openalex.org/keywords/vaccine-safety-and-tolerability","display_name":"vaccine safety and tolerability","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.8610456585884094},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5916663408279419},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5847399234771729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5270465016365051},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49255189299583435},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4867291748523712},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2498835325241089},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.07433894276618958},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26900452","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Immunological_and_clinical_long-term_effects_of_idiotype_vaccination_in_multiple_myeloma_patients/26900452","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/39621","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39621","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1482644575","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/39621/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/39621","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39621","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":316,"referenced_works":["https://openalex.org/W5181404","https://openalex.org/W18153787","https://openalex.org/W53338855","https://openalex.org/W83009012","https://openalex.org/W95253960","https://openalex.org/W121638319","https://openalex.org/W146271095","https://openalex.org/W149604985","https://openalex.org/W175951554","https://openalex.org/W196804521","https://openalex.org/W226917763","https://openalex.org/W280395377","https://openalex.org/W347594833","https://openalex.org/W1043396468","https://openalex.org/W1483933457","https://openalex.org/W1492157159","https://openalex.org/W1493376557","https://openalex.org/W1497803497","https://openalex.org/W1498187417","https://openalex.org/W1499850570","https://openalex.org/W1499984377","https://openalex.org/W1500188050","https://openalex.org/W1508383316","https://openalex.org/W1509043987","https://openalex.org/W1509909867","https://openalex.org/W1512178367","https://openalex.org/W1522859339","https://openalex.org/W1526986700","https://openalex.org/W1533843272","https://openalex.org/W1535389268","https://openalex.org/W1546871754","https://openalex.org/W1556003072","https://openalex.org/W1567420244","https://openalex.org/W1579641819","https://openalex.org/W1581712504","https://openalex.org/W1598429767","https://openalex.org/W1601097153","https://openalex.org/W1603713470","https://openalex.org/W1605269473","https://openalex.org/W1640362455","https://openalex.org/W1796792338","https://openalex.org/W1798928306","https://openalex.org/W1815105900","https://openalex.org/W1840993518","https://openalex.org/W1897308167","https://openalex.org/W1900001467","https://openalex.org/W1912494263","https://openalex.org/W1914208484","https://openalex.org/W1914496726","https://openalex.org/W1923382223","https://openalex.org/W1955150056","https://openalex.org/W1959650359","https://openalex.org/W1966178583","https://openalex.org/W1968336371","https://openalex.org/W1970008554","https://openalex.org/W1971439358","https://openalex.org/W1972308909","https://openalex.org/W1972409257","https://openalex.org/W1972693902","https://openalex.org/W1973251492","https://openalex.org/W1975609541","https://openalex.org/W1976079129","https://openalex.org/W1976730089","https://openalex.org/W1976952965","https://openalex.org/W1976963122","https://openalex.org/W1976999017","https://openalex.org/W1977140231","https://openalex.org/W1977179270","https://openalex.org/W1977348505","https://openalex.org/W1977367197","https://openalex.org/W1978266626","https://openalex.org/W1978377409","https://openalex.org/W1981957319","https://openalex.org/W1982499121","https://openalex.org/W1982864677","https://openalex.org/W1983664228","https://openalex.org/W1984375282","https://openalex.org/W1984484036","https://openalex.org/W1984677655","https://openalex.org/W1984942962","https://openalex.org/W1985390917","https://openalex.org/W1986501999","https://openalex.org/W1987009989","https://openalex.org/W1989052512","https://openalex.org/W1990811870","https://openalex.org/W1991026262","https://openalex.org/W1992699637","https://openalex.org/W1993029819","https://openalex.org/W1994639677","https://openalex.org/W1996123836","https://openalex.org/W1996445917","https://openalex.org/W1997296950","https://openalex.org/W1998463682","https://openalex.org/W1999191024","https://openalex.org/W2000080558","https://openalex.org/W2000626804","https://openalex.org/W2001012146","https://openalex.org/W2001191575","https://openalex.org/W2001616190","https://openalex.org/W2002251604","https://openalex.org/W2002326951","https://openalex.org/W2002899826","https://openalex.org/W2002927100","https://openalex.org/W2004525785","https://openalex.org/W2004708987","https://openalex.org/W2005739777","https://openalex.org/W2006382315","https://openalex.org/W2006569323","https://openalex.org/W2007693806","https://openalex.org/W2008482418","https://openalex.org/W2009371357","https://openalex.org/W2009714643","https://openalex.org/W2012723575","https://openalex.org/W2013567199","https://openalex.org/W2013729631","https://openalex.org/W2013996808","https://openalex.org/W2016896026","https://openalex.org/W2016928970","https://openalex.org/W2017815853","https://openalex.org/W2019214729","https://openalex.org/W2021488008","https://openalex.org/W2024025543","https://openalex.org/W2025666947","https://openalex.org/W2026426963","https://openalex.org/W2026608413","https://openalex.org/W2027013182","https://openalex.org/W2028461084","https://openalex.org/W2028827702","https://openalex.org/W2030780518","https://openalex.org/W2031678073","https://openalex.org/W2032918947","https://openalex.org/W2033378587","https://openalex.org/W2034269086","https://openalex.org/W2034490744","https://openalex.org/W2035298740","https://openalex.org/W2036483033","https://openalex.org/W2037626742","https://openalex.org/W2037883865","https://openalex.org/W2038634602","https://openalex.org/W2038968394","https://openalex.org/W2039215669","https://openalex.org/W2040402105","https://openalex.org/W2041981056","https://openalex.org/W2042627347","https://openalex.org/W2044016062","https://openalex.org/W2044450973","https://openalex.org/W2044698568","https://openalex.org/W2045927984","https://openalex.org/W2046818057","https://openalex.org/W2048121640","https://openalex.org/W2049929103","https://openalex.org/W2050161362","https://openalex.org/W2052329251","https://openalex.org/W2052337699","https://openalex.org/W2053230893","https://openalex.org/W2053508383","https://openalex.org/W2053508680","https://openalex.org/W2054864726","https://openalex.org/W2056756517","https://openalex.org/W2056892048","https://openalex.org/W2057722738","https://openalex.org/W2058397693","https://openalex.org/W2058471214","https://openalex.org/W2059518883","https://openalex.org/W2060496777","https://openalex.org/W2061596342","https://openalex.org/W2061743409","https://openalex.org/W2063192133","https://openalex.org/W2063413889","https://openalex.org/W2063827408","https://openalex.org/W2063939064","https://openalex.org/W2065007341","https://openalex.org/W2067489645","https://openalex.org/W2068862486","https://openalex.org/W2070393014","https://openalex.org/W2071248901","https://openalex.org/W2073628362","https://openalex.org/W2074221799","https://openalex.org/W2077260509","https://openalex.org/W2077423482","https://openalex.org/W2077717095","https://openalex.org/W2078493291","https://openalex.org/W2079527930","https://openalex.org/W2080239239","https://openalex.org/W2083036201","https://openalex.org/W2083117448","https://openalex.org/W2083426483","https://openalex.org/W2084289122","https://openalex.org/W2084471123","https://openalex.org/W2084912502","https://openalex.org/W2085257327","https://openalex.org/W2088238485","https://openalex.org/W2089434243","https://openalex.org/W2089791159","https://openalex.org/W2092692004","https://openalex.org/W2093757149","https://openalex.org/W2094798767","https://openalex.org/W2096005550","https://openalex.org/W2096625946","https://openalex.org/W2097074641","https://openalex.org/W2097191776","https://openalex.org/W2097710494","https://openalex.org/W2098958083","https://openalex.org/W2098983864","https://openalex.org/W2099135330","https://openalex.org/W2100811673","https://openalex.org/W2104148554","https://openalex.org/W2104152689","https://openalex.org/W2104494161","https://openalex.org/W2104550035","https://openalex.org/W2104805990","https://openalex.org/W2106037763","https://openalex.org/W2107031620","https://openalex.org/W2107140931","https://openalex.org/W2107629538","https://openalex.org/W2109635468","https://openalex.org/W2110027836","https://openalex.org/W2112012653","https://openalex.org/W2114441564","https://openalex.org/W2115531908","https://openalex.org/W2116032799","https://openalex.org/W2116400839","https://openalex.org/W2117029520","https://openalex.org/W2117043005","https://openalex.org/W2117172636","https://openalex.org/W2117837347","https://openalex.org/W2119045499","https://openalex.org/W2119191850","https://openalex.org/W2120161314","https://openalex.org/W2120474651","https://openalex.org/W2121158603","https://openalex.org/W2121566625","https://openalex.org/W2121626779","https://openalex.org/W2122181070","https://openalex.org/W2124560610","https://openalex.org/W2124749346","https://openalex.org/W2125559109","https://openalex.org/W2125604001","https://openalex.org/W2126009525","https://openalex.org/W2126767360","https://openalex.org/W2128659799","https://openalex.org/W2130822830","https://openalex.org/W2132207502","https://openalex.org/W2132874160","https://openalex.org/W2133986577","https://openalex.org/W2134060682","https://openalex.org/W2134692810","https://openalex.org/W2134812217","https://openalex.org/W2137318638","https://openalex.org/W2137862013","https://openalex.org/W2138077682","https://openalex.org/W2138733343","https://openalex.org/W2139029604","https://openalex.org/W2139849891","https://openalex.org/W2140529720","https://openalex.org/W2142149038","https://openalex.org/W2144129115","https://openalex.org/W2148245227","https://openalex.org/W2150460844","https://openalex.org/W2150678612","https://openalex.org/W2151888958","https://openalex.org/W2152627678","https://openalex.org/W2152678202","https://openalex.org/W2154404342","https://openalex.org/W2160108273","https://openalex.org/W2160117150","https://openalex.org/W2161545566","https://openalex.org/W2162129085","https://openalex.org/W2162819001","https://openalex.org/W2164244787","https://openalex.org/W2164296948","https://openalex.org/W2165107917","https://openalex.org/W2165290424","https://openalex.org/W2165362420","https://openalex.org/W2165788078","https://openalex.org/W2165945881","https://openalex.org/W2167087371","https://openalex.org/W2167897482","https://openalex.org/W2182114137","https://openalex.org/W2187113243","https://openalex.org/W2199385258","https://openalex.org/W2234907176","https://openalex.org/W2241302377","https://openalex.org/W2245046744","https://openalex.org/W2253202597","https://openalex.org/W2262776735","https://openalex.org/W2276129771","https://openalex.org/W2277336310","https://openalex.org/W2306701420","https://openalex.org/W2308068770","https://openalex.org/W2322831770","https://openalex.org/W2324498474","https://openalex.org/W2327578324","https://openalex.org/W2330691125","https://openalex.org/W2337393898","https://openalex.org/W2340099916","https://openalex.org/W2349179360","https://openalex.org/W2389656443","https://openalex.org/W2396994141","https://openalex.org/W2397148027","https://openalex.org/W2397666787","https://openalex.org/W2403639238","https://openalex.org/W2403668281","https://openalex.org/W2409125979","https://openalex.org/W2410000428","https://openalex.org/W2410127938","https://openalex.org/W2410838643","https://openalex.org/W2416091309","https://openalex.org/W2417243799","https://openalex.org/W2418514436","https://openalex.org/W2424422162","https://openalex.org/W2559032651","https://openalex.org/W2592202132","https://openalex.org/W2737127893","https://openalex.org/W3020936561","https://openalex.org/W4313341512"],"related_works":["https://openalex.org/W2049575138","https://openalex.org/W1788479098","https://openalex.org/W2105646210","https://openalex.org/W2588107096","https://openalex.org/W2061720114","https://openalex.org/W2163766076","https://openalex.org/W2102307567","https://openalex.org/W2277336310","https://openalex.org/W2013567199","https://openalex.org/W2032863816"],"abstract_inverted_index":{"In":[0,85,207,279,344,452],"spite":[1],"of":[2,67,82,94,140,183,192,205,238,262,271,296,309,315,366,385,426,447,468,482,485,493,508,541,576,596,618,642,694,721,736,798],"the":[3,21,77,83,86,91,126,208,226,260,280,316,324,329,345,369,376,386,424,434,453,466,506,613,725],"promising":[4],"results":[5,66,556],"shown":[6],"by":[7,217,333,474,697],"new":[8],"anti-myeloma":[9],"agents,":[10],"multiple":[11,218,692,737,771,805],"myeloma":[12,51,470,738,772],"(MM)":[13],"remains":[14],"incurable":[15],"and":[16,64,75,79,102,104,164,241,264,293,335,373,443,465,510,582,599,611,649,733,766],"additional":[17],"therapy":[18,39],"to":[19,110,132,137,152,189,252,303,340,400,406,414,545],"overcome":[20],"inevitable":[22],"disease":[23,401],"recurrence":[24],"is":[25,29,48,194],"greatly":[26],"needed.":[27],"Immunotherapy":[28],"currently":[30],"under":[31],"evaluation":[32],"as":[33,113,352,578,580],"a":[34,49,143,160,236,254,267,276,306,338,341,438,479,523,526,606],"novel":[35],"alternative":[36],"or":[37,235,764],"complementary":[38],"in":[40,58,70,107,120,221,290,311,364,368,375,410,423,433,497,505,511,561,646,684,689,730,768,802],"many":[41],"cancer":[42],"types.":[43],"The":[44],"idiotype":[45,722],"(Id)":[46],"protein":[47,682],"unique":[50],"specific":[52,184,392,548,726],"antigen":[53],"that":[54,172,328,558,571],"may":[55,198,572,585,590],"be":[56,111,133,148,178,200,407,517,591,605],"targeted":[57],"therapeutic":[59],"vaccination.":[60,488],"This":[61],"thesis":[62],"presents":[63],"discusses":[65],"ld":[68,227,487,559],"vaccination":[69,683,723,760,795],"early":[71,562,769],"stage":[72,563,770],"MM":[73,564],"patients":[74,223,273,310,349,367,388,432,456,501,513,565,690,803],"underscores":[76],"immunological":[78],"clinical":[80,439,583],"effects":[81,720],"vaccine.":[84],"first":[87],"study":[88,282,455],"we":[89,301],"analyzed":[90],"time":[92,127,334,399,476,481],"kinetics":[93],"cytokine":[95,173,643],"genes":[96,174],"expression":[97,158,175,645],"(IL-2,":[98],"IL-5,":[99],"IFNgamma,":[100],"GM-CSF":[101,265],"TNF-alpha)":[103],"granzyme":[105],"B":[106,156,197,471],"healthy":[108],"donors":[109],"used":[112],"supplementary":[114],"markers":[115],"for":[116,128,150,459,609],"antigen-specific":[117],"I":[118],"lymphocytes":[119],"subsequent":[121],"studies.":[122],"For":[123],"most":[124],"cytokines,":[125],"maximum":[129],"accumulation":[130,167],"seemed":[131],"obtained":[134],"after":[135,180,202],"4":[136],"8":[138],"h":[139,182,191,204],"activation.":[141,206],"However,":[142],"sustained":[144],"high":[145],"level":[146,529],"could":[147,515],"noticed":[149],"up":[151,188],"24":[153,190],"h.":[154],"Granzyme":[155,196],"gene":[157,644],"showed":[159,327,502,522],"continuous":[161],"gradual":[162],"increase":[163,422,504],"late":[165,325],"maximal":[166],"(48-72":[168],"h).":[169],"We":[170],"concluded":[171],"would":[176],"better":[177],"measured":[179,201],"4-8":[181],"stimulation,":[185],"but":[186,274],"also":[187,586],"stimulation":[193],"acceptable.":[195],"preferentially":[199],"48":[203],"second":[209],"study,":[210,347],"Id-specific":[211,283,299,358,461,532],"T":[212,284,359,462,533,549,727],"cell":[213,285,360,463,534,550,728],"responses":[214,286,300,317,330,361,570,584,696],"were":[215,287,350,362,457,495],"evaluated":[216],"read-out":[219,699],"systems":[220],"18":[222],"vaccinated":[224],"with":[225,229,275,321,420,538,574,593,686,691,762,804],"together":[228],"either":[230],"interleukin":[231],"(IL)-":[232],"12":[233,240,371,378],"alone":[234,249],"combination":[237,261,685],"IL-":[239,370],"granulocyte":[242],"macrophage":[243],"colony":[244],"stimulating":[245],"factor":[246],"(GM-CSF).":[247],"IL12":[248,263],"was":[250,404,418],"noted":[251,363],"induce":[253,567],"Th1":[255,339],"polarized":[256],"immune":[257,411,569,615],"response,":[258,464,535],"while":[259,394,536],"induced":[266,796],"significantly":[268,332,408],"higher":[269],"frequency":[270,308],"responding":[272],"Th2":[277,342],"profile.":[278,343],"third":[281,384],"monitored":[288,458],"simultaneously":[289],"peripheral":[291,731],"blood":[292,732],"bone":[294,734],"marrow":[295,735],"10":[297],"patients.":[298,499],"found":[302,405],"occur":[304],"at":[305,323],"similar":[307],"both":[312],"compartments.":[313],"Comparison":[314],"during":[318,478],"active":[319],"immunization":[320,560],"those":[322,537],"follow-up":[326],"decreased":[331],"shifted":[336],"from":[337],"fourth":[346],"28":[348],"immunized":[351],"indicated":[353],"earlier":[354],"over":[355],"110":[356],"weeks.":[357],"33%":[365],"group":[372,379,436],"85%":[374],"GM-CSF/IL":[377],"(p":[380],"-":[381],"0.003).":[382],"Two":[383,431],"responsive":[387],"subsequently":[389],"lost":[390],"their":[391,448],"immunity":[393,551],"developing":[395],"progressive":[396,503,600],"disease.":[397,601],"Median":[398],"progression":[402],"(TTP)":[403],"longer":[409],"responders":[412],"compared":[413],"non-responders.":[415],"Immune":[416,588],"non-response":[417,589],"associated":[419,592],"an":[421,460,531],"numbers":[425,540,595],"CD4+/CD25+":[427],"cells":[428,472,598,801],"(Treg":[429],"cells).":[430],"IL-12":[435,763,765],"had":[437],"response":[440,729],"(>":[441],"50%":[442],">":[444],"25%":[445],"reduction":[446,524,575],"respective":[449],"M-component":[450],"concentrations).":[451],"last":[454],"presence":[467],"circulating":[469,799],"(CMC)":[473],"real":[475],"ASO-PCR":[477],"median":[480],"46":[483],"weeks":[484],"maintained":[486],"Reduction":[489],"and/or":[490,525],"stable":[491,527],"levels":[492],"CMC":[494,509,514,528,542,577],"observed":[496],"6/11":[498],"Three":[500],"number":[507],"2":[512],"not":[516],"detected.":[518],"Patients":[519],"(n=6)":[520],"who":[521],"mounted":[530],"increasing":[539],"(n=3)":[543],"failed":[544],"mount":[546],"tumor":[547,800],"(p<0.02).":[552],"Taken":[553],"together,":[554],"these":[555],"indicate":[557],"can":[566,604],"tumor-specific":[568],"correlate":[573],"well":[579],"TTP,":[581],"occur.":[587],"increased":[594],"Treg":[597],"Adjuvant":[602],"cytokines":[603,688],"versatile":[607],"tool":[608],"manipulating":[610],"directing":[612],"anti-tumor":[614],"response.":[616],"List":[617],"scientific":[619],"papers":[620],"I.":[621],"Abdalla":[622,664,706,744,781],"AO,":[623,665,707,745,782],"Kiaii":[624],"S,":[625],"Hansson":[626,666,708,742,785],"L,":[627,667,709,743,786],"Rossmann":[628,672],"ED,":[629,673],"Jeddi-Tehrani":[630],"M,":[631],"Shokri":[632],"F,":[633],"Osterborg":[634,678,716,754,789],"A,":[635,747,749,755,790],"Mellstedt":[636,676,714,756,791],"H,":[637,675,677,715,751,788],"Rabbani":[638,674,750,787],"H":[639,757,792],"(2003).":[640],"\"Kinetics":[641],"human":[647],"CD4+":[648],"CD8+":[650],"T-lymphocyte":[651],"subsets":[652],"using":[653],"quantitative":[654],"real-time":[655],"PCR.\"":[656],"Scand":[657],"J":[658],"Immunol":[659],"58(6):":[660],"601-6.":[661],"https://pubmed.ncbi.nlm.nih.gov/14636415":[662],"II.":[663],"Eriksson":[668,710],"I,":[669,711],"Nasman-Glaser":[670,712],"B,":[671,713,753],"A":[679,717],"(2007).":[680,718,758,793],"\"Idiotype":[681,794],"adjuvant":[687],"myeloma--evaluation":[693],"T-cell":[695],"different":[698],"systems.\"":[700],"Haematologica":[701],"92(1):":[702],"110-4.":[703],"https://pubmed.ncbi.nlm.nih.gov/17229643":[704],"III.":[705],"\"Long-term":[719,759],"on":[724],"patients.\"":[739,773],"[Submitted]":[740],"IV.":[741],"Moshfegh":[746],"Choudhury":[748],"Nilsson":[752],"combined":[761],"GM-CSF,":[767],"Clin":[774],"Cancer":[775],"Res":[776],"13(5).":[777],"[Accepted]":[778],"https://pubmed.ncbi.nlm.nih.gov/17332295":[779],"V.":[780],"Kokhaei":[783],"P,":[784],"reduction/elimination":[797],"myeloma.\"":[806],"[Manuscript]":[807]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
