{"id":"https://openalex.org/W148251165","doi":"https://doi.org/10.1096/fasebj.21.5.a452-a","title":"The effect of oxidative stress on the function and protein composition of tight junctions in MDCK cells","display_name":"The effect of oxidative stress on the function and protein composition of tight junctions in MDCK cells","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W148251165","doi":"https://doi.org/10.1096/fasebj.21.5.a452-a","mag":"148251165"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a452-a","doi":"https://doi.org/10.1096/fasebj.21.5.a452-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a452-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068169054","display_name":"Jonathan M. King","orcid":"https://orcid.org/0000-0003-1791-0636","observed_orcids":["https://orcid.org/0000-0003-1791-0636"]},"institutions":[{"id":"https://openalex.org/I60060512","display_name":"Trinity University","ror":"https://ror.org/00t8gz605","country_code":"US","type":"education","lineage":["https://openalex.org/I60060512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. King","raw_affiliation_strings":["Biology Trinity University 1 Trinity Place San Antonio TX 78212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Trinity University 1 Trinity Place San Antonio TX 78212","institution_ids":["https://openalex.org/I60060512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083859815","display_name":"Jeannette E. Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799567722","display_name":"Wilford Hall Ambulatory Surgical Center","ror":"https://ror.org/025m0q735","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2799567722","https://openalex.org/I2802362820","https://openalex.org/I4210102105","https://openalex.org/I4210119345"]},{"id":"https://openalex.org/I4210089612","display_name":"United States Air Force","ror":"https://ror.org/006gmme17","country_code":"US","type":"government","lineage":["https://openalex.org/I1330347796","https://openalex.org/I4210089612","https://openalex.org/I4210102105"]},{"id":"https://openalex.org/I4210119345","display_name":"59th Medical Wing","ror":"https://ror.org/01sq4yt06","country_code":"US","type":"government","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2802362820","https://openalex.org/I4210102105","https://openalex.org/I4210119345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeannette E. Gonzalez","raw_affiliation_strings":["Pediatrics Wilford Hall USAF Medical Center 59th Medical Wing, 2200 Bergquist Dr. Lackland AFB TX 78236"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics Wilford Hall USAF Medical Center 59th Medical Wing, 2200 Bergquist Dr. Lackland AFB TX 78236","institution_ids":["https://openalex.org/I2799567722","https://openalex.org/I4210089612","https://openalex.org/I4210119345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060343924","display_name":"D'Ann E. Arthur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60060512","display_name":"Trinity University","ror":"https://ror.org/00t8gz605","country_code":"US","type":"education","lineage":["https://openalex.org/I60060512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D'Ann E. Arthur","raw_affiliation_strings":["Biology Trinity University 1 Trinity Place San Antonio TX 78212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Trinity University 1 Trinity Place San Antonio TX 78212","institution_ids":["https://openalex.org/I60060512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000412223","display_name":"Darcy L. Derickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60060512","display_name":"Trinity University","ror":"https://ror.org/00t8gz605","country_code":"US","type":"education","lineage":["https://openalex.org/I60060512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darcy L. Derickson","raw_affiliation_strings":["Biology Trinity University 1 Trinity Place San Antonio TX 78212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Trinity University 1 Trinity Place San Antonio TX 78212","institution_ids":["https://openalex.org/I60060512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01992719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.8119999766349792},{"id":"https://openalex.org/keywords/claudin-1","display_name":"claudin-1","score":1.0},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.8980000019073486},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.8799999952316284},{"id":"https://openalex.org/keywords/epithelial-barrier-function","display_name":"epithelial barrier function","score":0.7789999842643738},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7609999775886536},{"id":"https://openalex.org/keywords/renal-epithelial-cells","display_name":"renal epithelial cells","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6919640302658081},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6590222716331482},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.6346242427825928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6257706880569458},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.610303521156311},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.5913331508636475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5911468863487244},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4504639804363251},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.41739022731781006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35620516538619995},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.28655651211738586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26418831944465637},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05881166458129883}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a452-a","doi":"https://doi.org/10.1096/fasebj.21.5.a452-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a452-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992478515","https://openalex.org/W205071066","https://openalex.org/W2149661114","https://openalex.org/W7208124380","https://openalex.org/W2125190311","https://openalex.org/W101391507","https://openalex.org/W2399474039","https://openalex.org/W914042087","https://openalex.org/W4408813500","https://openalex.org/W2098983357"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1],"has":[2,44],"been":[3,45],"linked":[4,62],"to":[5,24,47,63,80,84,114,179,188,223],"many":[6],"disease":[7],"processes,":[8],"including":[9],"ischemia\u2010reperfusion":[10],"injury":[11,58],"and":[12,59,87,95,125,135,149,201,208,226],"toxicant":[13],"damage.":[14],"Loss":[15],"of":[16,35,103,132,137,146,155,169,177,203,233],"barrier":[17,77,104],"function":[18,78,160],"in":[19,26,73,199,216],"renal":[20],"epithelial":[21],"cells":[22,218],"due":[23,79],"alterations":[25],"the":[27,33,88,107,138,170,204,214,234],"tight":[28],"junction":[29],"(TJ)":[30],"may":[31,60],"complicate":[32],"effects":[34,74],"oxidative":[36],"stress.":[37],"The":[38],"mitogen\u2010activated":[39],"protein":[40,65],"kinase":[41],"(MAPK)":[42],"pathway":[43],"shown":[46],"be":[48,61],"an":[49,167],"early":[50],"cellular":[51],"signal":[52],"during":[53],"hydrogen":[54,85,147,156,180,189,224],"peroxide":[55,86,148,157,181,190,225],"exposure":[56,83,178,222],"oxidant":[57],"TJ":[64,133,159,205,215],"alterations.":[66],"In":[67],"this":[68],"study,":[69],"we":[70],"are":[71,229],"interested":[72],"on":[75],"cell":[76],"a":[81,101,163],"brief":[82],"ensuing":[89],"recovery":[90,193],"period.":[91],"Transepithelial":[92],"electrical":[93],"resistance":[94],"paracellular":[96],"flux":[97],"were":[98],"used":[99,113,129],"as":[100,182],"measure":[102],"integrity,":[105],"while":[106],"lactate":[108],"dehydrogenase":[109],"activity":[110],"assay":[111],"was":[112,119,128,151,173,194],"assess":[115],"cytotoxicity.":[116],"Protein":[117],"expression":[118,200],"determined":[120,183],"via":[121],"Western":[122],"blot":[123],"analysis,":[124],"immunofluorescent":[126],"staining":[127],"for":[130],"localization":[131,202],"proteins":[134,206],"examination":[136],"actin":[139],"cytoskeleton.":[140],"A":[141],"positive":[142],"relationship":[143],"between":[144],"dose":[145],"cytotoxicity":[150],"observed.":[152],"Low":[153],"doses":[154],"perturb":[158],"without":[161],"exhibiting":[162],"cytotoxic":[164],"effect.":[165],"ERK\u20101/2,":[166],"enzyme":[168],"MAPK":[171,235],"pathway,":[172],"activated":[174],"within":[175],"minutes":[176],"by":[184,221,231],"phospho\u2010ERK":[185],"content.":[186],"Exposure":[187],"with":[191,197],"subsequent":[192],"also":[195],"associated":[196],"changes":[198,228],"occludin":[207],"claudin\u20101.":[209],"These":[210],"findings":[211],"demonstrate":[212],"that":[213],"MDCK":[217],"is":[219],"altered":[220],"these":[227],"preceded":[230],"activation":[232],"pathway.":[236]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
