{"id":"https://openalex.org/W1482431563","doi":null,"title":"Absence of age-related dopamine transporter loss in current cocaine abusers","display_name":"Absence of age-related dopamine transporter loss in current cocaine abusers","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W1482431563","mag":"1482431563"},"language":"en","primary_location":{"id":"mag:1482431563","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/563331-absence-age-related-dopamine-transporter-loss-current-cocaine-abusers","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081492952","display_name":"Gene\u2010Jack Wang","orcid":"https://orcid.org/0000-0002-5017-9905","observed_orcids":["https://orcid.org/0000-0002-5017-9905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G.J. Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002969658","display_name":"Nora D. Volkow","orcid":"https://orcid.org/0000-0001-6668-0908","observed_orcids":["https://orcid.org/0000-0001-6668-0908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nora D. Volkow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6668-0908","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108464328","display_name":"Marian W. Fischman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marian W. Fischman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04493281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-abuse","display_name":"cocaine abuse","score":0.5899999737739563},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9769999980926514},{"id":"https://openalex.org/keywords/age-related-decline","display_name":"age-related decline","score":0.7900000214576721},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":0.47999998927116394},{"id":"https://openalex.org/keywords/cocaine-detoxification","display_name":"cocaine detoxification","score":0.4819999933242798},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.49399998784065247},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.8963884115219116},{"id":"https://openalex.org/C2779796075","wikidata":"https://www.wikidata.org/wiki/Q3743188","display_name":"Cocaine dependence","level":3,"score":0.5598841905593872},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5444108843803406},{"id":"https://openalex.org/C2992175768","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Drug abuser","level":3,"score":0.5352139472961426},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4824984073638916},{"id":"https://openalex.org/C3020194580","wikidata":"https://www.wikidata.org/wiki/Q41576","display_name":"Cocaine use","level":2,"score":0.4737466275691986},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.4674331545829773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44422733783721924},{"id":"https://openalex.org/C2910455596","wikidata":"https://www.wikidata.org/wiki/Q3743188","display_name":"Cocaine abuse","level":2,"score":0.42383524775505066},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.42266589403152466},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.4186175465583801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3514865040779114},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3306928277015686},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.215423583984375},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.2146517038345337},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20556005835533142},{"id":"https://openalex.org/C40010229","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Substance abuse","level":2,"score":0.20043063163757324},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19168972969055176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17532381415367126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1482431563","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/563331-absence-age-related-dopamine-transporter-loss-current-cocaine-abusers","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059422142","https://openalex.org/W2042148521","https://openalex.org/W7162037186","https://openalex.org/W205653918","https://openalex.org/W4252239379","https://openalex.org/W2119527667","https://openalex.org/W2048230052","https://openalex.org/W2126097810","https://openalex.org/W1506870724","https://openalex.org/W1011237665"],"abstract_inverted_index":{"The":[0],"brain":[1,182],"dopamine":[2],"(DA)":[3],"system":[4],"appears":[5],"to":[6,76,116,137,155,181,221,264,281],"play":[7],"a":[8,70,91,143,236],"crucial":[9],"role":[10],"in":[11,25,32,36,51,78,130,139,149,157,173,189,194,225,242,245,251,262],"the":[12,124,127,131,171,174,178,190,195,239,246,269],"reinforcing":[13],"properties":[14],"of":[15,93,98,103,110,126,133,145,238,271],"cocaine.":[16],"Using":[17],"PET":[18,66,117],"we":[19],"had":[20,90],"previously":[21],"shown":[22],"significant":[23],"decreases":[24],"DA":[26,33],"D2":[27],"receptors":[28],"but":[29,192],"no":[30,168],"changes":[31,278],"transporters":[34],"(DAT)":[35],"detoxified":[37],"cocaine":[38,44,53,99,111,150,232,247,253,267],"abusers":[39,54,89,151,196,233,254],"(>1":[40],"month":[41],"after":[42,258],"last":[43,108],"use).":[45],"This":[46],"study":[47,219],"evaluates":[48],"DAT":[49,71,119,147,198,226,243,272,283],"availability":[50,120,148,227,244],"current":[52,231],"(15":[55],"male":[56,80],"and":[57,67,73,81,106,230,285],"5":[58],"female;":[59],"age":[60,84,202,274],"=":[61,205,208,212],"36.2{+-}5.3":[62],"years":[63,105],"old)":[64],"using":[65,123],"[C-11]cocaine,":[68],"as":[69],"ligand,":[72],"compares":[74],"it":[75,234],"that":[77,138,156],"18":[79],"2":[82],"female":[83],"matched":[85],"normal":[86],"controls.":[87],"Cocaine":[88],"history":[92],"abusing":[94],"4.2{+-}2.8":[95],"gm":[96],"/week":[97],"for":[100,186],"an":[101],"average":[102],"11.0{+-}4.9":[104],"their":[107],"use":[109],"was":[112,121],"5.4{+-}8":[113],"days":[114],"prior":[115],"study.":[118],"obtained":[122],"ratio":[125],"distribution":[128,175],"volume":[129,176],"region":[132],"interest":[134],"(caudate,":[135],"pulamen)":[136],"cerebellum":[140],"which":[141],"is":[142],"function":[144],"Bmax./Kd.+1.":[146],"did":[152],"not":[153,193],"differ":[154],"normals":[158,191,229],"(N)":[159],"(C=":[160],"1.78{+-}0.14,":[161],"N=":[162],"1.77{+-}0.13).":[163],"In":[164],"addition,":[165],"there":[166],"were":[167],"differences":[169,224],"between":[170,228],"groups":[172],"or":[177,275],"Kl":[179],"(plasma":[180],"transfer":[183],"constant)":[184],"measures":[185],"[C-11]cocaine.":[187],"However,":[188],"striatal":[197],"availabilitymore\u00a0\u00bb":[199],"decreased":[200],"with":[201,273,287],"(C:":[203],"r":[204,211],"-0.07,":[206],"p":[207,214],"0.76;":[209],"N:":[210],"-0.55,":[213],"<":[215],"0.01).":[216],"Though":[217],"this":[218],"fails":[220],"show":[222],"group":[223],"indicates":[235],"blunting":[237],"age-related":[240],"decline":[241],"abusers.":[248],"Future":[249],"studies":[250],"older":[252],"at":[255],"different":[256],"time":[257],"detoxification":[259],"arc":[260],"required":[261],"order":[263],"assess":[265],"if":[266],"slows":[268],"loss":[270],"whether":[276],"these":[277],"reflect":[279],"compensation":[280],"increased":[282],"blockade":[284],"recover":[286],"detoxification.\u00ab\u00a0less":[288]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
