{"id":"https://openalex.org/W1482270252","doi":null,"title":"The clinical physiology of water metabolism. Part II: Renal mechanisms for urinary concentration; diabetes insipidus.","display_name":"The clinical physiology of water metabolism. Part II: Renal mechanisms for urinary concentration; diabetes insipidus.","publication_year":1979,"publication_date":"1979-12-01","ids":{"openalex":"https://openalex.org/W1482270252","mag":"1482270252","pmid":"https://pubmed.ncbi.nlm.nih.gov/545867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1271910"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1271910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1271910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1271910","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109915598","display_name":"Richard E. Weitzman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Weitzman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110880205","display_name":"Charles R. Kleeman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C R Kleeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5156,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62382719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"131","issue":"6","first_page":"486","last_page":"515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.16940000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/water-metabolism","display_name":"water metabolism","score":0.9760000109672546},{"id":"https://openalex.org/keywords/urine-concentration","display_name":"urine concentration","score":0.7509999871253967},{"id":"https://openalex.org/keywords/diabetes-insipidus","display_name":"diabetes insipidus","score":0.7630000114440918},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.878000020980835},{"id":"https://openalex.org/keywords/collecting-duct","display_name":"collecting duct","score":0.6990000009536743},{"id":"https://openalex.org/keywords/loop-of-henle","display_name":"loop of Henle","score":0.9800000190734863},{"id":"https://openalex.org/keywords/central-diabetes-insipidus","display_name":"central diabetes insipidus","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nephrogenic-diabetes-insipidus","display_name":"nephrogenic diabetes insipidus","score":1.0},{"id":"https://openalex.org/keywords/polyuria","display_name":"polyuria","score":0.9319999814033508},{"id":"https://openalex.org/keywords/vasopressin-therapy","display_name":"vasopressin therapy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/desmopressin","display_name":"desmopressin","score":0.796999990940094},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sodium-chloride-reabsorption","display_name":"sodium chloride reabsorption","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2776844834","wikidata":"https://www.wikidata.org/wiki/Q1813955","display_name":"Loop of Henle","level":4,"score":0.7845804691314697},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7445233464241028},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7096471190452576},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.6504241228103638},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.5997745394706726},{"id":"https://openalex.org/C2776958162","wikidata":"https://www.wikidata.org/wiki/Q220551","display_name":"Diabetes insipidus","level":2,"score":0.5808743238449097},{"id":"https://openalex.org/C2780180277","wikidata":"https://www.wikidata.org/wiki/Q1124286","display_name":"Polyuria","level":3,"score":0.5387393832206726},{"id":"https://openalex.org/C2780512574","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal medulla","level":3,"score":0.5277676582336426},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4584990441799164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.445988267660141},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.4446321129798889},{"id":"https://openalex.org/C85562759","wikidata":"https://www.wikidata.org/wiki/Q14902527","display_name":"Aquaporin 2","level":4,"score":0.41300705075263977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33750414848327637},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1705716848373413},{"id":"https://openalex.org/C2775845273","wikidata":"https://www.wikidata.org/wiki/Q7973466","display_name":"Water channel","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C201289731","wikidata":"https://www.wikidata.org/wiki/Q1172599","display_name":"Inlet","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003919","descriptor_name":"Diabetes Insipidus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003919","descriptor_name":"Diabetes Insipidus","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007671","descriptor_name":"Kidney Concentrating Ability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1271910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1271910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},{"id":"pmid:545867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/545867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Western journal of medicine","raw_type":"Journal Article"},{"id":"mag:1482270252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/545867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1271910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1271910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8015000224113464}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1904572595","https://openalex.org/W1918423059","https://openalex.org/W1937929403","https://openalex.org/W1963764779","https://openalex.org/W1963851874","https://openalex.org/W1964365020","https://openalex.org/W1965200950","https://openalex.org/W1972074660","https://openalex.org/W1974663421","https://openalex.org/W1975285476","https://openalex.org/W1979599420","https://openalex.org/W1981598048","https://openalex.org/W1982162713","https://openalex.org/W1982622677","https://openalex.org/W1983452485","https://openalex.org/W1987446089","https://openalex.org/W1996506545","https://openalex.org/W1997374036","https://openalex.org/W1998247785","https://openalex.org/W1999338306","https://openalex.org/W2003008639","https://openalex.org/W2005113309","https://openalex.org/W2006133307","https://openalex.org/W2008069830","https://openalex.org/W2009431304","https://openalex.org/W2010332894","https://openalex.org/W2011378341","https://openalex.org/W2012976828","https://openalex.org/W2013216313","https://openalex.org/W2013411561","https://openalex.org/W2014937936","https://openalex.org/W2020815069","https://openalex.org/W2021835558","https://openalex.org/W2022455843","https://openalex.org/W2027098170","https://openalex.org/W2028066203","https://openalex.org/W2030483106","https://openalex.org/W2031649069","https://openalex.org/W2031896985","https://openalex.org/W2031903425","https://openalex.org/W2034368653","https://openalex.org/W2040010386","https://openalex.org/W2043633897","https://openalex.org/W2044220170","https://openalex.org/W2044947980","https://openalex.org/W2052222980","https://openalex.org/W2053227740","https://openalex.org/W2055703311","https://openalex.org/W2061108904","https://openalex.org/W2062170214","https://openalex.org/W2063742966","https://openalex.org/W2070445492","https://openalex.org/W2071469435","https://openalex.org/W2072195837","https://openalex.org/W2072821372","https://openalex.org/W2076652673","https://openalex.org/W2077511227","https://openalex.org/W2080479947","https://openalex.org/W2102276163","https://openalex.org/W2111110375","https://openalex.org/W2128708579","https://openalex.org/W2129294026","https://openalex.org/W2140875007","https://openalex.org/W2156190864","https://openalex.org/W2159629680","https://openalex.org/W2188681416","https://openalex.org/W2276513905","https://openalex.org/W2323110840","https://openalex.org/W2323207500","https://openalex.org/W2337080608","https://openalex.org/W2397379487","https://openalex.org/W2400403157","https://openalex.org/W2401851029","https://openalex.org/W2409137975","https://openalex.org/W2419315015","https://openalex.org/W2419383707","https://openalex.org/W2469612837","https://openalex.org/W2616856216","https://openalex.org/W2898917476","https://openalex.org/W4229529792","https://openalex.org/W4239454737"],"related_works":["https://openalex.org/W88627427","https://openalex.org/W4282925613","https://openalex.org/W2129294026","https://openalex.org/W4232543645","https://openalex.org/W4405816031","https://openalex.org/W2040623992","https://openalex.org/W2044757191","https://openalex.org/W2415540637","https://openalex.org/W2167414585","https://openalex.org/W2032001781"],"abstract_inverted_index":{"The":[0,28,69,245],"renal":[1,80,306],"reabsorption":[2,73],"of":[3,6,11,15,23,26,31,37,40,43,50,98,113,141,155,159,175,194,208,241,280,302,305,324,335],"water":[4,57,153,168,257],"independent":[5],"solute":[7],"is":[8,58,74,83,102,185,203,247,254,262,287,311,329],"the":[9,12,16,20,24,32,38,44,48,61,67,75,79,94,111,127,138,152,156,162,176,180,186,214,218],"result":[10,301],"coordinated":[13],"function":[14,49],"collecting":[17,163],"duct":[18],"and":[19,34,42,64,130,346],"ascending":[21,33,96],"limb":[22],"loop":[25,39,97],"Henle.":[27,99],"unique":[29],"juxtaposition":[30],"descending":[35],"portions":[36],"Henle":[41],"vasa":[45],"recta":[46],"permits":[47],"a":[51,114,166,192,196,239,242,263,277,290,300,320,333,341],"counter-current":[52],"multiplier":[53],"system":[54],"in":[55,78,85,110,137,147,161,344],"which":[56,82,146],"removed":[59],"from":[60,93],"tubular":[62,177],"lumen":[63,178],"reabsorbed":[65],"into":[66,179],"circulation.":[68],"driving":[70],"force":[71],"for":[72],"osmotic":[76,172],"gradient":[77,173],"medulla":[81],"dependent,":[84],"part,":[86],"on":[87,126],"chloride":[88],"(followed":[89],"by":[90,122,249,276,289],"sodium)":[91],"pumping":[92],"thick":[95],"Urea":[100],"trapping":[101],"also":[103],"thought":[104],"to":[105,124,198,205,212,266,282,314],"play":[106],"an":[107,171],"important":[108],"role":[109],"generation":[112],"hypertonic":[115],"medullary":[116,181],"interstitium.":[117,182],"Arginine":[118],"vasopressin":[119,268],"(AVP)":[120],"acts":[121],"binding":[123],"receptors":[125],"cell":[128],"membrane":[129,158],"activating":[131],"adenylate":[132],"cyclase.":[133],"This,":[134],"inturn,":[135],"results":[136],"intracellular":[139],"accumulation":[140],"cyclic":[142],"adenosine":[143],"monophosphate":[144],"(AMP)":[145],"some":[148],"fashion":[149],"abruptly":[150],"increases":[151],"permeability":[154],"luminal":[157],"cells":[160],"duct.":[164],"As":[165],"consequence,":[167],"flows":[169],"along":[170],"out":[174],"Diabetes":[183],"insipidus":[184,202,272,286,310,328],"clinical":[187],"condition":[188],"associated":[189],"with":[190,234,318,332],"either":[191,213],"deficiency":[193],"or":[195,217,229],"resistance":[197],"AVP.":[199,283,325],"Central":[200,308],"diabetes":[201,271,285,309,327],"due":[204],"diminished":[206],"release":[207],"AVP":[209],"following":[210],"damage":[211],"neurosecretory":[215],"nuclei":[216],"pituitary":[219],"stalk.":[220],"Possible":[221],"causes":[222],"include":[223],"idiopathic,":[224],"familial,":[225],"trauma,":[226],"tumor,":[227],"infection":[228],"vascular":[230],"lesions.":[231],"Patients":[232],"present":[233],"polyuria,":[235],"usually":[236],"beginning":[237],"over":[238],"period":[240],"few":[243],"days.":[244],"diagnosis":[246],"made":[248],"showing":[250],"that":[251,260],"urinary":[252],"concentration":[253],"impaired":[255],"after":[256],"restriction":[258],"but":[259],"there":[261],"good":[264],"response":[265,281],"exogenous":[267],"therapy.":[269],"Nephrogenic":[270,284,326],"can":[273,296],"be":[274,297],"identified":[275],"patient's":[278],"lack":[279],"caused":[288],"familial":[291],"defect,":[292],"although":[293],"milder":[294],"forms":[295,304],"acquired":[298],"as":[299,338,340],"various":[303],"disease.":[307],"eminently":[312],"responsive":[313],"replacement":[315],"therapy,":[316],"particularly":[317],"dDAVP,":[319],"long":[321],"lasting":[322],"analogue":[323],"best":[330],"treated":[331],"combination":[334],"thiazide":[336],"diuretics":[337],"well":[339],"diet":[342],"low":[343],"sodium":[345],"protein.":[347]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
