{"id":"https://openalex.org/W1481831972","doi":null,"title":"Improvement of the Solubility and Dissolution Rate of the Steroidal Drug, Mesterolone, using Cyclodextrin Complexation","display_name":"Improvement of the Solubility and Dissolution Rate of the Steroidal Drug, Mesterolone, using Cyclodextrin Complexation","publication_year":2010,"publication_date":"2010-08-16","ids":{"openalex":"https://openalex.org/W1481831972","mag":"1481831972"},"language":"en","primary_location":{"id":"mag:1481831972","doi":null,"is_oa":false,"landing_page_url":"https://journals.ju.edu.jo/JMJ/article/download/1187/1178","pdf_url":null,"source":{"id":"https://openalex.org/S87542449","display_name":"Jordan Medical Journal","issn_l":"0446-9283","issn":["0446-9283","2664-8091"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319222","host_organization_name":"University of Jordan","host_organization_lineage":["https://openalex.org/P4310319222"],"host_organization_lineage_names":["University of Jordan"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Jordan Medical Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Samer Odeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samer Odeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000749876","display_name":"H. Muti","orcid":"https://orcid.org/0000-0001-9878-0233","observed_orcids":["https://orcid.org/0000-0001-9878-0233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Muti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9878-0233","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066160375","display_name":"Ahmad Bani-Jaber","orcid":"https://orcid.org/0000-0002-2468-6954","observed_orcids":["https://orcid.org/0000-0002-2468-6954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmad Bani-Jaber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2468-6954","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06306164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesterolone","display_name":"mesterolone","score":1.0},{"id":"https://openalex.org/keywords/cyclodextrin-inclusion-complexation","display_name":"cyclodextrin inclusion complexation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/beta-cyclodextrin","display_name":"\u03b2-cyclodextrin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hydroxypropyl-beta-cyclodextrin","display_name":"hydroxypropyl-\u03b2-cyclodextrin","score":1.0},{"id":"https://openalex.org/keywords/solubility-enhancement","display_name":"solubility enhancement","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.7860000133514404},{"id":"https://openalex.org/keywords/stability-constants","display_name":"stability constants","score":0.7519999742507935},{"id":"https://openalex.org/keywords/kneading","display_name":"kneading","score":0.6800000071525574},{"id":"https://openalex.org/keywords/co-evaporation","display_name":"co-evaporation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/steroid-hormones","display_name":"steroid hormones","score":0.5630000233650208},{"id":"https://openalex.org/keywords/drug-solubilization","display_name":"drug solubilization","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.8556671738624573},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.8460325002670288},{"id":"https://openalex.org/C46275449","wikidata":"https://www.wikidata.org/wiki/Q2458815","display_name":"Crystallinity","level":2,"score":0.8405632972717285},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6325187087059021},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.5318579077720642},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4693717956542969},{"id":"https://openalex.org/C2779433975","wikidata":"https://www.wikidata.org/wiki/Q40417805","display_name":"Cyclodextrin","level":2,"score":0.4471896290779114},{"id":"https://openalex.org/C2781144210","wikidata":"https://www.wikidata.org/wiki/Q172275","display_name":"Chloroform","level":2,"score":0.4266117811203003},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.31061455607414246},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.168501079082489},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1479591429233551},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.040054649114608765},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1481831972","doi":null,"is_oa":false,"landing_page_url":"https://journals.ju.edu.jo/JMJ/article/download/1187/1178","pdf_url":null,"source":{"id":"https://openalex.org/S87542449","display_name":"Jordan Medical Journal","issn_l":"0446-9283","issn":["0446-9283","2664-8091"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319222","host_organization_name":"University of Jordan","host_organization_lineage":["https://openalex.org/P4310319222"],"host_organization_lineage_names":["University of Jordan"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Jordan Medical Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W127380770","https://openalex.org/W1967623516","https://openalex.org/W1987495059","https://openalex.org/W1996481160","https://openalex.org/W1999424668","https://openalex.org/W2032503242","https://openalex.org/W2042373769","https://openalex.org/W2053797549","https://openalex.org/W2088536216","https://openalex.org/W2096004054","https://openalex.org/W2104530167","https://openalex.org/W2283449839"],"related_works":["https://openalex.org/W187831176","https://openalex.org/W2023082007","https://openalex.org/W1985084738","https://openalex.org/W2225700976","https://openalex.org/W6886050413","https://openalex.org/W4312186643","https://openalex.org/W1613299913","https://openalex.org/W7156992492","https://openalex.org/W2074754449","https://openalex.org/W2444043225"],"abstract_inverted_index":{"Inclusion":[0],"complexation":[1],"between":[2],"mesterolone":[3],"(MN),":[4],"a":[5],"steroidal":[6],"hormone,":[7],"and":[8,19,35,39,53,79,89,112,120,133,146,154,174,195,220,232,258],"\u03b2-cyclodextrin":[9],"(\u03b2CD)":[10],"or":[11,31],"hydroxypropyl-\u03b2-cyclodextrin":[12],"(HP\u03b2CD)":[13],"was":[14,46,54,125,136,218,221,242],"evaluated":[15],"in":[16,20,208,215,239],"aqueous":[17],"environment":[18],"solid":[21,114],"state.":[22],"Phase":[24],"solubility":[25,51],"profiles":[26],"of":[27,70,86,156,190,234],"MN":[28,106,123,152,157,216,240],"with":[29,74,138,141,198,252],"\u03b2CD":[30,61,139,176],"HP\u03b2CD":[32,142,179],"were":[33,72,102,160,203],"obtained":[34,73,219],"classified":[36],"as":[37],"AL-type":[38],"BL-type,":[40],"respectively.":[41],"An":[42,213],"apparent":[43],"stability":[44],"constant":[45],"calculated":[47],"from":[48],"each":[49,181],"phase":[50],"profile":[52],"found":[55,243],"to":[56,94,205,210,244],"be":[57],"higher":[58,137,161],"for":[59,63,104,113,171,175,178,255],"MN-":[60,64],"than":[62,140,165,177],"HP\u03b2CD.":[65],"Solid":[67],"binary":[68,100,201],"systems":[69,101,202],"MN-CD":[71],"both":[75,144,172],"CDs":[76,173],"by":[77,109,116],"kneading":[78,145,194],"coevaporation":[80,196],"at":[81,162,166,180],"MN:":[82,129,248],"CD":[83,130,249,256],"molar":[84,131,169,182,250],"ratios":[85],"1:":[87,90,163,167],"1":[88,168],"2.":[91],"In":[92],"comparison":[93,209],"the":[95,99,188],"respective":[96],"physical":[97],"mixtures,":[98],"characterized":[103],"%":[105],"complex":[107],"inclusion":[108,124,153,231],"chloroform":[110],"extraction":[111],"state":[115],"differential":[117],"scanning":[118],"calorimetry":[119],"X-ray":[121,184],"diffractometry.":[122],"mostly":[126],"dependent":[127],"on":[128,224,247],"ratio":[132,170,251],"this":[134],"dependence":[135],"upon":[143,193],"coevaporation.":[147],"The":[148,200,237],"DSC":[149],"results":[150,186],"indicated":[151],"loss":[155,189,233],"crystallinity,":[158],"which":[159],"2":[164],"ratio.":[183],"diffraction":[185],"confirmed":[187],"drug":[191,226,230,235],"crystallinity":[192],"particularly":[197],"\u03b2CD.":[199],"subjected":[204],"dissolution":[206,217,241],"studies":[207],"pure":[211],"MN.":[212],"enhancement":[214,238],"explained":[222],"based":[223],"local":[225],"solubilization":[227],"during":[228],"dissolution,":[229],"crystallinity.":[236],"strongly":[245],"depend":[246],"slight":[253],"effect":[254],"type":[257],"preparation":[259],"method.":[260]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}